AutismKB 2.0

Annotation Details for EZH2


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Basic Information Top
Gene Symbol:EZH2 ( ENX-1,ENX1,EZH1,KMT6,KMT6A,MGC9169 )
Gene Full Name: enhancer of zeste homolog 2 (Drosophila)
Band: 7q36.1
Quick LinksEntrez ID:2146; OMIM: 601573; Uniprot ID:EZH2_HUMAN; ENSEMBL ID: ENSG00000106462; HGNC ID: 3527
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin19734898
GO:0005634IDA-nucleus19144645
GO:0005654TAS-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO:0035098IDA-ESC/E(Z) complex15385962
GO:0045120IEA-pronucleus-
GO ID Evidence Qualifier GO_term References
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0001047ISS-core promoter binding-
GO:0003677TAS-DNA binding8954776
GO:0003682IDA-chromatin binding20154697
GO:0005515IPI-protein binding11571280
GO:0016279TAS-protein-lysine N-methyltransferase activity-
GO:0018024IDA-histone-lysine N-methyltransferase activity19144645
GO:0018024TAS-histone-lysine N-methyltransferase activity-
GO:0031490IDA-chromatin DNA binding19734898
GO:0042054IDA-histone methyltransferase activity15385962
GO:0042054IMP-histone methyltransferase activity26694085
GO:0043021IEA-ribonucleoprotein complex binding-
GO:0046976IDA-histone methyltransferase activity (H3-K27 specific)22323599
GO:0046976TAS-histone methyltransferase activity (H3-K27 specific)24474760
GO:0070878IEA-primary miRNA binding-
GO:1990841IDA-promoter-specific chromatin binding24623306
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter20154697
GO:0006306IEA-DNA methylation-
GO:0006325TAS-chromatin organization8921387
GO:0006351IEA-transcription, DNA-templated-
GO:0006355TAS-regulation of transcription, DNA-templated8921387
GO:0010718IDA-positive regulation of epithelial to mesenchymal transition20154697
GO:0014013IEA-regulation of gliogenesis-
GO:0014834IEA-skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration-
GO:0014898IEA-cardiac muscle hypertrophy in response to stress-
GO:0016571IMP-histone methylation26694085
GO:0021695IEA-cerebellar cortex development-
GO:0021766IEA-hippocampus development-
GO:0032355IEA-response to estradiol-
GO:0034244IEA-negative regulation of transcription elongation from RNA polymerase II promoter-
GO:0035984IEA-cellular response to trichostatin A-
GO:0036333IEA-hepatocyte homeostasis-
GO:0042127IEA-regulation of cell proliferation-
GO:0042752IMP-regulation of circadian rhythm16717091
GO:0043406IDA-positive regulation of MAP kinase activity20154697
GO:0043433IEA-negative regulation of sequence-specific DNA binding transcription factor activity-
GO:0043547IDA-positive regulation of GTPase activity20154697
GO:0045605IEA-negative regulation of epidermal cell differentiation-
GO:0045814IDA-negative regulation of gene expression, epigenetic20154697
GO:0045814IMP-negative regulation of gene expression, epigenetic24623306
GO:0045814TAS-negative regulation of gene expression, epigenetic-
GO:0045892IMP-negative regulation of transcription, DNA-templated16179254
GO:0048387IMP-negative regulation of retinoic acid receptor signaling pathway16179254
GO:0048511IEA-rhythmic process-
GO:0051154IEA-negative regulation of striated muscle cell differentiation-
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0070314IEA-G1 to G0 transition-
GO:0070734IDA-histone H3-K27 methylation24474760
GO:0071168IEA-protein localization to chromatin-
GO:0071902IDA-positive regulation of protein serine/threonine kinase activity20154697
GO:0097421IEA-liver regeneration-
GO:0098532IEA-histone H3-K27 trimethylation-
GO:1900006IEA-positive regulation of dendrite development-
GO:1904772IEA-response to tetrachloromethane-
GO:2000134IEA-negative regulation of G1/S transition of mitotic cell cycle-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EZH2AKT110671016224021 Affinity Capture-Western; Biochemical Activity
EZH2AKT110844616224021 Affinity Capture-Western; Biochemical Activity
EZH2ATP1A110844616169070 Two-hybrid
EZH2ATP1A110696616169070 Two-hybrid
EZH2ATRX1070289499421 Reconstituted Complex; Two-hybrid
EZH2ATRX1084469499421 Reconstituted Complex; Two-hybrid
EZH2CTNNB110788019661437 Affinity Capture-Western
EZH2CTNNB110844619661437 Affinity Capture-Western
EZH2DNMT110812316357870 Affinity Capture-Western; Reconstituted Complex
EZH2DNMT110844616357870 Affinity Capture-Western; Reconstituted Complex
EZH2DNMT3A10812516357870 Affinity Capture-Western; Reconstituted Complex
EZH2DNMT3A10844616357870 Affinity Capture-Western; Reconstituted Complex
EZH2DNMT3B10812616357870 Affinity Capture-Western; Reconstituted Complex
EZH2DNMT3B10844616357870 Affinity Capture-Western; Reconstituted Complex
EZH2E2F610820815536069 16565076 Affinity Capture-Western
EZH2E2F610844615536069 16565076 Affinity Capture-Western
EZH2EWSR110843120211142 Two-hybrid
EZH2EWSR110844620211142 Two-hybrid
EZH2EZH110844519026780 19026781 Affinity Capture-Western
EZH2EZH110844619026780 19026781 Affinity Capture-Western
VAV1EZH21084468649418 15882624 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VAV1EZH21132528649418 15882624 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EEDEZH21084469584197 9742080 10581039 15225548 15385962 15882624 16314526 17937919 18285464 18931660 19026780 19026781 Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex; Two-hybrid
EEDEZH21142659584197 9742080 10581039 15225548 15385962 15882624 16314526 17937919 18285464 18931660 19026780 19026781 Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex; Two-hybrid
HDAC1EZH210931510581039 15520282 Affinity Capture-Western
HDAC1EZH210844610581039 15520282 Affinity Capture-Western
HDAC2EZH210931610581039 Affinity Capture-Western
HDAC2EZH210844610581039 Affinity Capture-Western
PHF1EZH211127111571280 18285464 18385154 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
PHF1EZH210844611571280 18285464 18385154 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
SETD8EZH213249012351676 Co-purification
SETD8EZH210844612351676 Co-purification
RBL2EZH210844615077161 Affinity Capture-Western; Reconstituted Complex
RBL2EZH211186915077161 Affinity Capture-Western; Reconstituted Complex
MYOD1EZH211073715520282 Affinity Capture-Western
MYOD1EZH210844615520282 Affinity Capture-Western
YY1EZH210844615520282 Affinity Capture-Western; Co-localization
YY1EZH211336015520282 Affinity Capture-Western; Co-localization
EPC1EZH212322715536069 Affinity Capture-Western; Two-hybrid
EPC1EZH210844615536069 Affinity Capture-Western; Two-hybrid
SIRT1EZH210844615684044 Affinity Capture-Western
SIRT1EZH211698315684044 Affinity Capture-Western
SUZ12EZH211705915882624 18285464 18453536 18483221 18931660 19026780 19026781 20123894 Affinity Capture-MS; Affinity Capture-Western
SUZ12EZH210844615882624 18285464 18453536 18483221 18931660 19026780 19026781 20123894 Affinity Capture-MS; Affinity Capture-Western
NINLEZH210844616169070 Two-hybrid
NINLEZH211663016169070 Two-hybrid
KLHDC2EZH210844616169070 Two-hybrid
KLHDC2EZH211712316169070 Two-hybrid
POLA2EZH211717616169070 Two-hybrid
POLA2EZH210844616169070 Two-hybrid
GTF3C1EZH210923016169070 Two-hybrid
GTF3C1EZH210844616169070 Two-hybrid
PIN4EZH211132016169070 Two-hybrid
PIN4EZH210844616169070 Two-hybrid
WSB2EZH210844616169070 Two-hybrid
WSB2EZH212097616169070 Two-hybrid
PSMB6EZH210844616169070 Two-hybrid
PSMB6EZH211166716169070 Two-hybrid
RPN2EZH210844616169070 Two-hybrid
RPN2EZH211210016169070 Two-hybrid
WDR61EZH212325516169070 Two-hybrid
WDR61EZH210844616169070 Two-hybrid
CCDC85BEZH210844616189514 Two-hybrid
CCDC85BEZH211619816189514 Two-hybrid
HIST1H3AEZH210844616224021 16431907 Affinity Capture-Western; Biochemical Activity
HIST1H3AEZH211394616224021 16431907 Affinity Capture-Western; Biochemical Activity
HIST1H1AEZH210927516431907 Reconstituted Complex
HIST1H1AEZH210844616431907 Reconstituted Complex
ZMYND11EZH210844616565076 Affinity Capture-Western
ZMYND11EZH211598916565076 Affinity Capture-Western
PHB2EZH210844617453341 Reconstituted Complex
PHB2EZH211645917453341 Reconstituted Complex
PPP1R8EZH211150317804093 Affinity Capture-Western; Reconstituted Complex
PPP1R8EZH210844617804093 Affinity Capture-Western; Reconstituted Complex
KDM5AEZH210844618483221 Affinity Capture-Western
KDM5AEZH211186218483221 Affinity Capture-Western
SNAI1EZH210844618519590 Affinity Capture-Western
SNAI1EZH211249918519590 Affinity Capture-Western
EZH2EZH210844619026781 Affinity Capture-Western
KDM2BEZH212419719202064 Affinity Capture-Western
KDM2BEZH210844619202064 Affinity Capture-Western
RBBP4EZH210844620123894 Affinity Capture-MS
RBBP4EZH211186320123894 Affinity Capture-MS
MTF2EZH210844620123894 Affinity Capture-MS; Affinity Capture-Western
MTF2EZH211649920123894 Affinity Capture-MS; Affinity Capture-Western
JARID2EZH210992320123894 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
JARID2EZH210844620123894 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
YY1EZH219683214610174 EED interacts with EZH2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107940
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041111-259'