AutismKB 2.0

Annotation Details for F2


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Basic Information Top
Gene Symbol:F2 ( PT )
Gene Full Name: coagulation factor II (thrombin)
Band: 11p11.2
Quick LinksEntrez ID:2147; OMIM: 176930; Uniprot ID:THRB_HUMAN; ENSEMBL ID: ENSG00000180210; HGNC ID: 3535
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space9639571
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005796TAS-Golgi lumen-
GO:0005886TAS-plasma membrane-
GO:0009897IDAcolocalizes_withexternal side of plasma membrane20421939
GO:0070062IDA-extracellular exosome23376485
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0001530IDA-lipopolysaccharide binding20421939
GO:0004252IDA-serine-type endopeptidase activity1672265
GO:0004252TAS-serine-type endopeptidase activity-
GO:0005102IPI-receptor binding8626514
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding3279057
GO:0008083TAS-growth factor activity8626514
GO:0008201IDA-heparin binding20421939
GO:0070053IDA-thrombospondin receptor activity2435757
GO ID Evidence Qualifier GO_term References
GO:0001934IDA-positive regulation of protein phosphorylation7559487
GO:0006465TAS-signal peptide processing-
GO:0006508TAS-proteolysis7507931
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0006953IEA-acute-phase response-
GO:0007166IDA-cell surface receptor signaling pathway1672265
GO:0007275TAS-multicellular organism development9639571
GO:0007596TAS-blood coagulation-
GO:0007597TAS-blood coagulation, intrinsic pathway-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008360IEA-regulation of cell shape-
GO:0009611IDA-response to wounding9639571
GO:0010544TAS-negative regulation of platelet activation17379830
GO:0014068IEA-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0017187TAS-peptidyl-glutamic acid carboxylation-
GO:0030168IDA-platelet activation9038223
GO:0030168TAS-platelet activation-
GO:0030193TAS-regulation of blood coagulation12855810
GO:0030194IDA-positive regulation of blood coagulation9038223
GO:0030307IEA-positive regulation of cell growth-
GO:0030449TAS-regulation of complement activation-
GO:0032967IDA-positive regulation of collagen biosynthetic process9639571
GO:0042730IDA-fibrinolysis12855810
GO:0044267TAS-cellular protein metabolic process-
GO:0045861IDA-negative regulation of proteolysis1695900
GO:0048712IDA-negative regulation of astrocyte differentiation1691280
GO:0050900TAS-leukocyte migration-
GO:0051281IDA-positive regulation of release of sequestered calcium ion into cytosol1672265
GO:0051480IDA-regulation of cytosolic calcium ion concentration19052258
GO:0051838IDA-cytolysis by host of symbiont cells20421939
GO:0051918TAS-negative regulation of fibrinolysis17379830
GO:0061844IDA-antimicrobial humoral immune response mediated by antimicrobial peptide20421939
GO:0070945IDA-neutrophil mediated killing of gram-negative bacterium20421939
GO:0090218IDA-positive regulation of lipid kinase activity11309392
GO:1900016IDA-negative regulation of cytokine production involved in inflammatory response20421939
GO:1900182IDA-positive regulation of protein localization to nucleus11309392
GO:1900738IDA-positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway20164183
GO:2000379IDA-positive regulation of reactive oxygen species metabolic process17275676
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
F2SERPING110717111460008 Reconstituted Complex
F2SERPING110844711460008 Reconstituted Complex
F2CPB21077538663147 Reconstituted Complex
F2CPB21084478663147 Reconstituted Complex
FGAF21085341587268 Co-crystal Structure
FGAF21084471587268 Co-crystal Structure
THBS1F21129152435757 Reconstituted Complex
THBS1F21084472435757 Reconstituted Complex
THBDF21129142544585 8663147 Reconstituted Complex
THBDF21084472544585 8663147 Reconstituted Complex
SERPINB6F21112878415716 Reconstituted Complex
SERPINB6F21084478415716 Reconstituted Complex
F5F21084479032460 Reconstituted Complex
F5F21084529032460 Reconstituted Complex
PLATF211134310543954 Co-crystal Structure
PLATF210844710543954 Co-crystal Structure
ITGA2BF210844711487023 Reconstituted Complex
ITGA2BF210988111487023 Reconstituted Complex
SERPIND1F210930312169660 Co-crystal Structure
SERPIND1F210844712169660 Co-crystal Structure
SERPINE1F210844712709053 Reconstituted Complex
SERPINE1F211109112709053 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88380
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-4606'