AutismKB 2.0

Annotation Details for PTK2B


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Basic Information Top
Gene Symbol:PTK2B ( CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK )
Gene Full Name: PTK2B protein tyrosine kinase 2 beta
Band: 8p21.2
Quick LinksEntrez ID:2185; OMIM: 601212; Uniprot ID:FAK2_HUMAN; ENSEMBL ID: ENSG00000120899; HGNC ID: 9612
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus19880522
GO:0005737TAS-cytoplasm7499242
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005925IDA-focal adhesion18765415
GO:0005938IEA-cell cortex-
GO:0014069ISS-postsynaptic density-
GO:0017146ISS-NMDA selective glutamate receptor complex-
GO:0030027IDA-lamellipodium18765415
GO:0030424IEA-axon-
GO:0030425ISS-dendrite-
GO:0030426ISS-growth cone-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0043025ISS-neuronal cell body-
GO:0043197IEA-dendritic spine-
GO:0044297ISS-cell body-
GO:0045121IEA-membrane raft-
GO:0048471IDA-perinuclear region of cytoplasm18765415
GO:0097440ISS-apical dendrite-
GO ID Evidence Qualifier GO_term References
GO:0004683ISS-calmodulin-dependent protein kinase activity-
GO:0004713IDA-protein tyrosine kinase activity12771146
GO:0004715IDA-non-membrane spanning protein tyrosine kinase activity7544443
GO:0004871NAS-signal transducer activity10867021
GO:0004972ISScontributes_toNMDA glutamate receptor activity-
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding8849729
GO:0005524IEA-ATP binding-
GO:0031625IEA-ubiquitin protein ligase binding-
GO:0032403IEA-protein complex binding-
GO:0043423IEA-3-phosphoinositide-dependent protein kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0000165IEA-MAPK cascade-
GO:0001525IBA-angiogenesis-
GO:0001556IEA-oocyte maturation-
GO:0001666IEA-response to hypoxia-
GO:0001954IMP-positive regulation of cell-matrix adhesion18765415
GO:0002040ISS-sprouting angiogenesis-
GO:0002250IEA-adaptive immune response-
GO:0002315ISS-marginal zone B cell differentiation-
GO:0006461TAS-protein complex assembly10867021
GO:0006468TAS-protein phosphorylation7529876
GO:0006915TAS-apoptotic process10880513
GO:0006950TAS-response to stress8939945
GO:0006968ISS-cellular defense response-
GO:0006970IEA-response to osmotic stress-
GO:0007165TAS-signal transduction7499242
GO:0007166IMP-cell surface receptor signaling pathway8849729
GO:0007172IEA-signal complex assembly-
GO:0007173IBA-epidermal growth factor receptor signaling pathway-
GO:0007204IEA-positive regulation of cytosolic calcium ion concentration-
GO:0007229IMP-integrin-mediated signaling pathway15050747
GO:0008284IMP-positive regulation of cell proliferation18765415
GO:0008285IMP-negative regulation of cell proliferation15050747
GO:0008360IMP-regulation of cell shape19086031
GO:0009612IEA-response to mechanical stimulus-
GO:0009725IEA-response to hormone-
GO:0009749IEA-response to glucose-
GO:0010226IEA-response to lithium ion-
GO:0010595IDA-positive regulation of endothelial cell migration21245381
GO:0010656IEA-negative regulation of muscle cell apoptotic process-
GO:0010752IEA-regulation of cGMP-mediated signaling-
GO:0010758ISS-regulation of macrophage chemotaxis-
GO:0010976IMP-positive regulation of neuron projection development17910947
GO:0014009IEA-glial cell proliferation-
GO:0018108IDA-peptidyl-tyrosine phosphorylation7544443
GO:0030155IMP-regulation of cell adhesion19086031
GO:0030307IEA-positive regulation of cell growth-
GO:0030335IMP-positive regulation of cell migration18765415
GO:0030502ISS-negative regulation of bone mineralization-
GO:0030826IEA-regulation of cGMP biosynthetic process-
GO:0030838IMP-positive regulation of actin filament polymerization18765415
GO:0031175IEA-neuron projection development-
GO:0032960ISS-regulation of inositol trisphosphate biosynthetic process-
GO:0033209IMP-tumor necrosis factor-mediated signaling pathway8670418
GO:0035235ISS-ionotropic glutamate receptor signaling pathway-
GO:0035902IEA-response to immobilization stress-
GO:0038083IDA-peptidyl-tyrosine autophosphorylation9545257
GO:0038083ISS-peptidyl-tyrosine autophosphorylation-
GO:0042220IEA-response to cocaine-
GO:0042493IEA-response to drug-
GO:0042542IEA-response to hydrogen peroxide-
GO:0042976IMP-activation of Janus kinase activity8670418
GO:0043066IMP-negative regulation of apoptotic process19880522
GO:0043149IEA-stress fiber assembly-
GO:0043267IDA-negative regulation of potassium ion transport7544443
GO:0043507IEA-positive regulation of JUN kinase activity-
GO:0043524ISS-negative regulation of neuron apoptotic process-
GO:0043534IEA-blood vessel endothelial cell migration-
GO:0043552ISS-positive regulation of phosphatidylinositol 3-kinase activity-
GO:0045087IBA-innate immune response-
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045453ISS-bone resorption-
GO:0045471IEA-response to ethanol-
GO:0045638IMP-negative regulation of myeloid cell differentiation15050747
GO:0045727IEA-positive regulation of translation-
GO:0045766IEA-positive regulation of angiogenesis-
GO:0045860IMP-positive regulation of protein kinase activity7544443
GO:0046330IMP-positive regulation of JNK cascade8670418
GO:0046777TAS-protein autophosphorylation8849729
GO:0048010IMP-vascular endothelial growth factor receptor signaling pathway21245381
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048041IEA-focal adhesion assembly-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation10518561
GO:0050848IEA-regulation of calcium-mediated signaling-
GO:0051000IEA-positive regulation of nitric-oxide synthase activity-
GO:0051279ISS-regulation of release of sequestered calcium ion into cytosol-
GO:0051591IEA-response to cAMP-
GO:0051592IEA-response to calcium ion-
GO:0051968ISS-positive regulation of synaptic transmission, glutamatergic-
GO:0060291ISS-long-term synaptic potentiation-
GO:0060292IEA-long term synaptic depression-
GO:0070098ISS-chemokine-mediated signaling pathway-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade7544443
GO:0071300IMP-cellular response to retinoic acid17910947
GO:0071498IEA-cellular response to fluid shear stress-
GO:0090630IEA-activation of GTPase activity-
GO:2000058IDA-regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process19880522
GO:2000060IEA-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:2000114ISS-regulation of establishment of cell polarity-
GO:2000249ISS-regulation of actin cytoskeleton reorganization-
GO:2000310ISS-regulation of NMDA receptor activity-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
GO:2000538ISS-positive regulation of B cell chemotaxis-
GO:2000573IEA-positive regulation of DNA biosynthetic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PTK2BCBL10731511149930 15128873 Affinity Capture-Western
PTK2BCBL10848011149930 15128873 Affinity Capture-Western
PTK2BDCC10848015494733 Reconstituted Complex
PTK2BDCC10799815494733 Reconstituted Complex
PTK2BDLG310808512576483 Affinity Capture-Western; Reconstituted Complex
PTK2BDLG310848012576483 Affinity Capture-Western; Reconstituted Complex
PTK2BDLG410848012576483 Affinity Capture-Western; Reconstituted Complex
PTK2BDLG410808612576483 Affinity Capture-Western; Reconstituted Complex
PTK2BEGFR10848010777553 Affinity Capture-Western
PTK2BEGFR10827610777553 Affinity Capture-Western
PTK2BERBB210848010713673 Affinity Capture-Western
PTK2BERBB210837610713673 Affinity Capture-Western
PTK2BEWSR110843110322114 Affinity Capture-Western; Reconstituted Complex
PTK2BEWSR110848010322114 Affinity Capture-Western; Reconstituted Complex
SRCPTK2B1125928849729 10521452 10777553 Affinity Capture-Western; Reconstituted Complex
SRCPTK2B1084808849729 10521452 10777553 Affinity Capture-Western; Reconstituted Complex
BCAR1PTK2B1084808995252 9020138 11036077 Affinity Capture-Western
BCAR1PTK2B1149348995252 9020138 11036077 Affinity Capture-Western
NEDD9PTK2B1108169020138 Affinity Capture-Western
NEDD9PTK2B1084809020138 Affinity Capture-Western
LCKPTK2B1084809091579 Affinity Capture-Western
LCKPTK2B1101249091579 Affinity Capture-Western
FYNPTK2B1084809091579 9104812 10867021 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FYNPTK2B1088109091579 9104812 10867021 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PXNPTK2B1084809099734 9422762 11036077 Affinity Capture-Western; Far Western; Reconstituted Complex
PXNPTK2B1117879099734 9422762 11036077 Affinity Capture-Western; Far Western; Reconstituted Complex
SOCS3PTK2B1084809344848 Two-hybrid
SOCS3PTK2B1144889344848 Two-hybrid
TGFB1I1PTK2B1084809422762 9858471 11856738 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFB1I1PTK2B1128999422762 9858471 11856738 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TLN1PTK2B1129499442086 Affinity Capture-Western
TLN1PTK2B1084809442086 Affinity Capture-Western
JAK3PTK2B1084809512511 Affinity Capture-Western
JAK3PTK2B1099219512511 Affinity Capture-Western
PTK2BPTK2B1084809512511 Biochemical Activity
LPXNPTK2B1148019565592 Affinity Capture-Western
LPXNPTK2B1084809565592 Affinity Capture-Western
PITPNM3PTK2B10848010022914 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PITPNM3PTK2B12363610022914 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PITPNM2PTK2B12165310022914 Affinity Capture-Western; Two-hybrid
PITPNM2PTK2B10848010022914 Affinity Capture-Western; Two-hybrid
PITPNM1PTK2B11496510022914 Affinity Capture-Western; Two-hybrid
PITPNM1PTK2B10848010022914 Affinity Capture-Western; Two-hybrid
ASAP2PTK2B10848010022920 Affinity Capture-Western; Reconstituted Complex
ASAP2PTK2B11437810022920 Affinity Capture-Western; Reconstituted Complex
GRB2PTK2B10848010329689 Affinity Capture-Western
GRB2PTK2B10914210329689 Affinity Capture-Western
PTPN6PTK2B10848010521452 10747947 Affinity Capture-Western; Biochemical Activity
PTPN6PTK2B11174210521452 10747947 Affinity Capture-Western; Biochemical Activity
IL7RPTK2B10848010702271 Affinity Capture-Western
IL7RPTK2B10978910702271 Affinity Capture-Western
JAK1PTK2B10848010702271 Affinity Capture-Western
JAK1PTK2B10991910702271 Affinity Capture-Western
RASA1PTK2B10848010708762 10713673 Affinity Capture-Western; Reconstituted Complex
RASA1PTK2B11185610708762 10713673 Affinity Capture-Western; Reconstituted Complex
SYKPTK2B10848010747947 Affinity Capture-Western
SYKPTK2B11271710747947 Affinity Capture-Western
RB1CC1PTK2B10848010769033 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
RB1CC1PTK2B11516010769033 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
GNA13PTK2B11591410821841 Affinity Capture-Western
GNA13PTK2B10848010821841 Affinity Capture-Western
VAV1PTK2B11325210867021 Reconstituted Complex
VAV1PTK2B10848010867021 Reconstituted Complex
PTPN11PTK2B10848010880513 Affinity Capture-Western; Biochemical Activity; Far Western
PTPN11PTK2B11174510880513 Affinity Capture-Western; Biochemical Activity; Far Western
ITGB2PTK2B10989510961871 Affinity Capture-Western
ITGB2PTK2B10848010961871 Affinity Capture-Western
SLC2A1PTK2B10848011007796 Affinity Capture-Western
SLC2A1PTK2B11240411007796 Affinity Capture-Western
LYNPTK2B10848011311138 Affinity Capture-Western
LYNPTK2B11024511311138 Affinity Capture-Western
PTPN12PTK2B10848011337490 Biochemical Activity
PTPN12PTK2B11174611337490 Biochemical Activity
PRKCDPTK2B11156611352632 Affinity Capture-Western
PRKCDPTK2B10848011352632 Affinity Capture-Western
GRIN2APTK2B10916011478920 12576483 Affinity Capture-Western
GRIN2APTK2B10848011478920 12576483 Affinity Capture-Western
NPHP1PTK2B11092711493697 Affinity Capture-Western; Reconstituted Complex
NPHP1PTK2B10848011493697 Affinity Capture-Western; Reconstituted Complex
ITGB3PTK2B10848011683411 Reconstituted Complex
ITGB3PTK2B10989611683411 Reconstituted Complex
KCNA2PTK2B10994011739373 Affinity Capture-Western
KCNA2PTK2B10848011739373 Affinity Capture-Western
JAK2PTK2B10992011818507 Affinity Capture-Western
JAK2PTK2B10848011818507 Affinity Capture-Western
GSNPTK2B10918912578912 Affinity Capture-Western; Biochemical Activity; Two-hybrid
GSNPTK2B10848012578912 Affinity Capture-Western; Biochemical Activity; Two-hybrid
GIT1PTK2B10848012629171 Affinity Capture-Western
GIT1PTK2B11878912629171 Affinity Capture-Western
SORBS1PTK2B10848015128873 Affinity Capture-Western
SORBS1PTK2B11583115128873 Affinity Capture-Western
CD2APPTK2B10848015128873 Affinity Capture-Western
CD2APPTK2B11714015128873 Affinity Capture-Western
SORBS2PTK2B10848015128873 Affinity Capture-Western; Reconstituted Complex
SORBS2PTK2B11404715128873 Affinity Capture-Western; Reconstituted Complex
MBD2PTK2B10848019661918 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MBD2PTK2B11444519661918 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104908
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020507-1'