Annotation Details for KDM1B

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Basic Information Top

Gene Symbol:	KDM1B ( AOF1,C6orf193,DKFZp686I0412,FLJ33898,FLJ34109,FLJ43328,LSD2,bA204B7.3,dJ298J15.2 )
Gene Full Name:	lysine (K)-specific demethylase 1B
Band:	6p22.3
Quick Links	Entrez ID:221656; OMIM: 613081; Uniprot ID:KDM1B_HUMAN; ENSEMBL ID: ENSG00000165097; HGNC ID: 21577
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:3 results
Molecular Function:10 results
Biological Process:10 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0000786	IDA	-	nucleosome	23260659
GO:0005634	ISS	-	nucleus	19727073
GO:0005654	TAS	-	nucleoplasm	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003677	IEA	-	DNA binding	-
GO:0005515	IPI	-	protein binding	23260659
GO:0008270	IDA	-	zinc ion binding	23260659
GO:0032452	TAS	-	histone demethylase activity	-
GO:0034648	IDA	-	histone demethylase activity (H3-dimethyl-K4 specific)	23266887
GO:0034648	ISS	-	histone demethylase activity (H3-dimethyl-K4 specific)	19727073
GO:0034649	IDA	-	histone demethylase activity (H3-monomethyl-K4 specific)	23266887
GO:0034649	ISS	-	histone demethylase activity (H3-monomethyl-K4 specific)	19727073
GO:0042393	IDA	-	histone binding	23260659
GO:0071949	IDA	-	FAD binding	23260659

GO ID	Evidence	Qualifier	GO_term	References
GO:0006349	ISS	-	regulation of gene expression by genetic imprinting	19727073
GO:0006351	IEA	-	transcription, DNA-templated	-
GO:0006355	IEA	-	regulation of transcription, DNA-templated	-
GO:0007275	IEA	-	multicellular organism development	-
GO:0016579	TAS	-	protein deubiquitination	-
GO:0034720	IDA	-	histone H3-K4 demethylation	23266887
GO:0034720	ISS	-	histone H3-K4 demethylation	19727073
GO:0043046	IEA	-	DNA methylation involved in gamete generation	-
GO:0044030	ISS	-	regulation of DNA methylation	19727073
GO:0055114	IEA	-	oxidation-reduction process	-

Protein-Protein Interaction

BioGRID:2 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
KDM1B	BAP1	128743	19615732 19815555	Affinity Capture-MS
KDM1B	BAP1	113911	19615732 19815555	Affinity Capture-MS

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:2145261
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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