Annotation Details for FCN1

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Basic Information Top

Gene Symbol:	FCN1 ( FCNM )
Gene Full Name:	ficolin (collagen/fibrinogen domain containing) 1
Band:	9q34.3
Quick Links	Entrez ID:2219; OMIM: 601252; Uniprot ID:FCN1_HUMAN; ENSEMBL ID: ENSG00000085265; HGNC ID: 3623
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:5 results
Molecular Function:7 results
Biological Process:10 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	TAS	-	extracellular region	-
GO:0005581	IEA	-	collagen trimer	-
GO:0031232	IDA	-	extrinsic component of external side of plasma membrane	21037097
GO:0034774	TAS	-	secretory granule lumen	-
GO:1904813	TAS	-	ficolin-1-rich granule lumen	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001664	IPI	-	G-protein coupled receptor binding	21037097
GO:0004252	TAS	-	serine-type endopeptidase activity	-
GO:0005515	IPI	-	protein binding	17581635
GO:0008329	IMP	-	signaling pattern recognition receptor activity	21037097
GO:0030246	IEA	-	carbohydrate binding	-
GO:0033691	IDA	-	sialic acid binding	20400674
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001867	TAS	-	complement activation, lectin pathway	-
GO:0002752	IMP	-	cell surface pattern recognition receptor signaling pathway	21037097
GO:0006508	IEA	-	proteolysis	-
GO:0006956	TAS	-	complement activation	-
GO:0007186	IDA	-	G-protein coupled receptor signaling pathway	21037097
GO:0034394	IDA	-	protein localization to cell surface	20400674
GO:0043312	TAS	-	neutrophil degranulation	-
GO:0043654	IDA	-	recognition of apoptotic cell	15804047
GO:0046597	IDA	-	negative regulation of viral entry into host cell	22851708
GO:2000484	IMP	-	positive regulation of interleukin-8 secretion	21037097

Protein-Protein Interaction

BioGRID:4 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
FCN1	ELN	108321	8947836	Reconstituted Complex
FCN1	ELN	108513	8947836	Reconstituted Complex
TGFB1	FCN1	112898	7686157	Co-purification
TGFB1	FCN1	108513	7686157	Co-purification

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1340905
Data Attributes: MGI curated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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