AutismKB 2.0

Annotation Details for FDFT1


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Basic Information Top
Gene Symbol:FDFT1 ( DGPT,ERG9,SQS,SS )
Gene Full Name: farnesyl-diphosphate farnesyltransferase 1
Band: 8p23.1
Quick LinksEntrez ID:2222; OMIM: 184420; Uniprot ID:FDFT_HUMAN; ENSEMBL ID: ENSG00000079459; HGNC ID: 3629
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783IDA-endoplasmic reticulum-
GO:0005789IBA-endoplasmic reticulum membrane-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0004310IBA-farnesyl-diphosphate farnesyltransferase activity-
GO:0004310TAS-farnesyl-diphosphate farnesyltransferase activity-
GO:0005515IPI-protein binding25910212
GO:0016491IEA-oxidoreductase activity-
GO:0051996IBA-squalene synthase activity-
GO ID Evidence Qualifier GO_term References
GO:0006694TAS-steroid biosynthetic process8474436
GO:0006695IBA-cholesterol biosynthetic process-
GO:0006695TAS-cholesterol biosynthetic process-
GO:0006696IEA-ergosterol biosynthetic process-
GO:0008299IEA-isoprenoid biosynthetic process-
GO:0019216TAS-regulation of lipid metabolic process-
GO:0045338IBA-farnesyl diphosphate metabolic process-
GO:0045540TAS-regulation of cholesterol biosynthetic process-
GO:0055114IEA-oxidation-reduction process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FDFT1ANXA510680516169070 Two-hybrid
FDFT1ANXA510851616169070 Two-hybrid
RUVBL2FDFT111606716169070 Two-hybrid
RUVBL2FDFT110851616169070 Two-hybrid
ARL6IP1FDFT111681216169070 Two-hybrid
ARL6IP1FDFT110851616169070 Two-hybrid
SHPRHFDFT112920816169070 Two-hybrid
SHPRHFDFT110851616169070 Two-hybrid
TMEM43FDFT112260116169070 Two-hybrid
TMEM43FDFT110851616169070 Two-hybrid
SMNDC1FDFT111557417353931 Affinity Capture-MS
SMNDC1FDFT110851617353931 Affinity Capture-MS
RUVBL1FDFT111416617353931 Affinity Capture-MS
RUVBL1FDFT110851617353931 Affinity Capture-MS
PSTPIP1FDFT111451317353931 Affinity Capture-MS
PSTPIP1FDFT110851617353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102706
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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