AutismKB 2.0

Annotation Details for FEN1


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Basic Information Top
Gene Symbol:FEN1 ( FEN-1,MF1,RAD2 )
Gene Full Name: flap structure-specific endonuclease 1
Band: 11q12.2
Quick LinksEntrez ID:2237; OMIM: 600393; Uniprot ID:FEN1_HUMAN; ENSEMBL ID: ENSG00000168496; HGNC ID: 3650
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region19135898
GO:0000784IDAcolocalizes_withnuclear chromosome, telomeric region24270157
GO:0005634IDA-nucleus7961795
GO:0005654TAS-nucleoplasm-
GO:0005730IEA-nucleolus-
GO:0005739IDA-mitochondrion18995831
GO:0016020IDA-membrane19946888
GO:0043234IDA-protein complex25378300
GO ID Evidence Qualifier GO_term References
GO:0003677IMP-DNA binding11986308
GO:0003684TAS-damaged DNA binding8007985
GO:0003690TAS-double-stranded DNA binding8131753
GO:0004519TAS-endonuclease activity8131753
GO:0004523IDA-RNA-DNA hybrid ribonuclease activity7961795
GO:0004527TAS-exonuclease activity9778254
GO:0005515IPI-protein binding9305916
GO:0008309TAS-double-stranded DNA exodeoxyribonuclease activity8131753
GO:0008409IDA-5'-3' exonuclease activity7961795
GO:0017108IDA-5'-flap endonuclease activity18995831
GO:0017108IMP-5'-flap endonuclease activity8621570
GO:0017108TAS-5'-flap endonuclease activity-
GO:0046872IEA-metal ion binding-
GO:0048256IDA-flap endonuclease activity18499658
GO ID Evidence Qualifier GO_term References
GO:0000722TAS-telomere maintenance via recombination-
GO:0000724TAS-double-strand break repair via homologous recombination-
GO:0006260TAS-DNA replication9778254
GO:0006281TAS-DNA repair8007985
GO:0006302TAS-double-strand break repair8131753
GO:0007613IEA-memory-
GO:0009650TAS-UV protection8007985
GO:0043137IDA-DNA replication, removal of RNA primer18995831
GO:0045876IMP-positive regulation of sister chromatid cohesion18499658
GO:0090305IDA-nucleic acid phosphodiester bond hydrolysis18499658
GO:0090502IEA-RNA phosphodiester bond hydrolysis, endonucleolytic-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FEN1APEX110682511601988 Affinity Capture-Western; Reconstituted Complex
FEN1APEX110852811601988 Affinity Capture-Western; Reconstituted Complex
FEN1ARHGDIA10688916169070 Two-hybrid
FEN1ARHGDIA10852816169070 Two-hybrid
FEN1BLM10711014688284 16326861 Affinity Capture-Western; Reconstituted Complex
FEN1BLM10852814688284 16326861 Affinity Capture-Western; Reconstituted Complex
FEN1CCNA210733112853968 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FEN1CCNA210852812853968 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FEN1CDK110742012853968 Reconstituted Complex
FEN1CDK110852812853968 Reconstituted Complex
FEN1CDK210745212853968 Biochemical Activity; Reconstituted Complex
FEN1CDK210852812853968 Biochemical Activity; Reconstituted Complex
FEN1DDX1110802818499658 Affinity Capture-Western
FEN1DDX1110852818499658 Affinity Capture-Western
FEN1EEF1G10825716169070 Two-hybrid
FEN1EEF1G10852816169070 Two-hybrid
FEN1ENDOG10852816133872 Affinity Capture-Western
FEN1ENDOG10833616133872 Affinity Capture-Western
FEN1EP30010834711430825 16326861 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FEN1EP30010852811430825 16326861 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PCNAFEN11111428876181 9305916 9545252 11313979 11430825 11601988 12853968 16216273 17115032 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
PCNAFEN11085288876181 9305916 9545252 11313979 11430825 11601988 12853968 16216273 17115032 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
WRNFEN111332311598021 14688284 16326861 Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex
WRNFEN110852811598021 14688284 16326861 Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex
HNRNPA1FEN110942014690413 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HNRNPA1FEN110852814690413 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HUS1FEN110959616216273 Affinity Capture-Western
HUS1FEN110852816216273 Affinity Capture-Western
RAD1FEN110852816216273 Affinity Capture-Western
RAD1FEN111177116216273 Affinity Capture-Western
RAD9AFEN111182016216273 Affinity Capture-Western
RAD9AFEN110852816216273 Affinity Capture-Western
NCAPGFEN112208916543152 Affinity Capture-Western
NCAPGFEN110852816543152 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102779
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031112-11'