AutismKB 2.0

Annotation Details for FER


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Basic Information Top
Gene Symbol:FER ( TYK3 )
Gene Full Name: fer (fps/fes related) tyrosine kinase
Band: 5q21.3
Quick LinksEntrez ID:2241; OMIM: 176942; Uniprot ID:FER_HUMAN; ENSEMBL ID: ENSG00000151422; HGNC ID: 3655
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDAcolocalizes_withnuclear chromatin1990274
GO:0005634IDA-nucleus19147545
GO:0005737IDA-cytoplasm1990274
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005938IEA-cell cortex-
GO:0015629IDAcolocalizes_withactin cytoskeleton19738202
GO:0015630IDAcolocalizes_withmicrotubule cytoskeleton12972546
GO:0030027IDAcolocalizes_withlamellipodium19738202
GO:0030054IDAcolocalizes_withcell junction12972546
GO:0031234IDA-extrinsic component of cytoplasmic side of plasma membrane19738202
GO ID Evidence Qualifier GO_term References
GO:0004713TAS-protein tyrosine kinase activity2725517
GO:0004715IDA-non-membrane spanning protein tyrosine kinase activity12972546
GO:0005154IDA-epidermal growth factor receptor binding21518868
GO:0005515IPI-protein binding15226396
GO:0005524IEA-ATP binding-
GO:0008157IEA-protein phosphatase 1 binding-
GO:0008289IDA-lipid binding19738202
GO ID Evidence Qualifier GO_term References
GO:0000226IMP-microtubule cytoskeleton organization12972546
GO:0000278IMP-mitotic cell cycle22223638
GO:0001932ISS-regulation of protein phosphorylation-
GO:0006468TAS-protein phosphorylation2725517
GO:0006935IBA-chemotaxis-
GO:0007155IBA-cell adhesion-
GO:0007260IDA-tyrosine phosphorylation of STAT protein19147545
GO:0008283IMP-cell proliferation22223638
GO:0008284IMP-positive regulation of cell proliferation25540073
GO:0008284TAS-positive regulation of cell proliferation20111072
GO:0010591IDA-regulation of lamellipodium assembly19738202
GO:0010762IEA-regulation of fibroblast migration-
GO:0018108IDA-peptidyl-tyrosine phosphorylation12972546
GO:0019221IMP-cytokine-mediated signaling pathway9722593
GO:0030154IBA-cell differentiation-
GO:0030335IMP-positive regulation of cell migration19738202
GO:0030838IMP-positive regulation of actin filament polymerization19738202
GO:0031532ISS-actin cytoskeleton reorganization-
GO:0032496ISS-response to lipopolysaccharide-
GO:0032869ISS-cellular response to insulin stimulus-
GO:0033007ISS-negative regulation of mast cell activation involved in immune response-
GO:0034446ISS-substrate adhesion-dependent cell spreading-
GO:0034614ISS-cellular response to reactive oxygen species-
GO:0035426ISS-extracellular matrix-cell signaling-
GO:0035556TAS-intracellular signal transduction2209086
GO:0036006IMP-cellular response to macrophage colony-stimulating factor stimulus9722593
GO:0036119ISS-response to platelet-derived growth factor-
GO:0038028ISS-insulin receptor signaling pathway via phosphatidylinositol 3-kinase-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038095IBA-Fc-epsilon receptor signaling pathway-
GO:0038095ISS-Fc-epsilon receptor signaling pathway-
GO:0038109ISS-Kit signaling pathway-
GO:0042058IMP-regulation of epidermal growth factor receptor signaling pathway21518868
GO:0043304IBA-regulation of mast cell degranulation-
GO:0044331ISS-cell-cell adhesion mediated by cadherin-
GO:0045087IBA-innate immune response-
GO:0046777IDA-protein autophosphorylation7623846
GO:0048008ISS-platelet-derived growth factor receptor signaling pathway-
GO:0048008TAS-platelet-derived growth factor receptor signaling pathway11994747
GO:0050904ISS-diapedesis-
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity21518868
GO:0070102IMP-interleukin-6-mediated signaling pathway19147545
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FERCDH110853212640114 Reconstituted Complex
FERCDH110743412640114 Reconstituted Complex
FERCTNNB110788012640114 Biochemical Activity
FERCTNNB110853212640114 Biochemical Activity
FERDNM11080999722593 Co-fractionation
FERDNM11085329722593 Co-fractionation
FERDNM21085329722593 Co-fractionation
FERDNM21081229722593 Co-fractionation
FEREGFR1082767623846 Affinity Capture-Western
FEREGFR1085327623846 Affinity Capture-Western
FERCTTN1085329722593 Affinity Capture-Western; Biochemical Activity; Co-fractionation
FERCTTN1083329722593 Affinity Capture-Western; Biochemical Activity; Co-fractionation
FERFER1085329722593 Biochemical Activity
DNM3FER1175159722593 Co-fractionation
DNM3FER1085329722593 Co-fractionation
TMF1FER1129659742951 Biochemical Activity; Two-hybrid
TMF1FER1085329742951 Biochemical Activity; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:105917
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060526-234'