AutismKB 2.0

Annotation Details for FGA


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Basic Information Top
Gene Symbol:FGA ( Fib2,MGC119422,MGC119423,MGC119425 )
Gene Full Name: fibrinogen alpha chain
Band: 4q31.3
Quick LinksEntrez ID:2243; OMIM: 134820; Uniprot ID:FIBA_HUMAN; ENSEMBL ID: ENSG00000171560; HGNC ID: 3661
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005577IDA-fibrinogen complex8910396
GO:0005615IDA-extracellular space6777381
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005886TAS-plasma membrane-
GO:0005938IEA-cell cortex-
GO:0009897IDA-external side of plasma membrane6777381
GO:0009986IDA-cell surface6777381
GO:0031091IDA-platelet alpha granule6777381
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO:0072562IDA-blood microparticle22516433
GO:1903561IDA-extracellular vesicle24769233
GO ID Evidence Qualifier GO_term References
GO:0005102IDAcontributes_toreceptor binding10903502
GO:0005198IDA-structural molecule activity8910396
GO:0005198IMP-structural molecule activity10891444
GO:0005515IPI-protein binding10954706
GO:0030674IEA-protein binding, bridging-
GO:0046872IEA-metal ion binding-
GO:0050839IDAcontributes_tocell adhesion molecule binding9182580
GO ID Evidence Qualifier GO_term References
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002250IEA-adaptive immune response-
GO:0002576TAS-platelet degranulation-
GO:0006461IMP-protein complex assembly18676163
GO:0007160IDA-cell-matrix adhesion10903502
GO:0007596TAS-blood coagulation-
GO:0030198TAS-extracellular matrix organization-
GO:0031639IDA-plasminogen activation16846481
GO:0034116IDA-positive regulation of heterotypic cell-cell adhesion8100742
GO:0042730IDA-fibrinolysis16846481
GO:0043152IDA-induction of bacterial agglutination24367264
GO:0043623IDA-cellular protein complex assembly8910396
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0045087IEA-innate immune response-
GO:0045907IDA-positive regulation of vasoconstriction15739255
GO:0045921IDA-positive regulation of exocytosis19193866
GO:0050714IDA-positive regulation of protein secretion19193866
GO:0051258IDA-protein polymerization12706644
GO:0051592IDA-response to calcium ion6777381
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade10903502
GO:0070527IDA-platelet aggregation6281794
GO:0070527IMP-platelet aggregation23382103
GO:0072377IMP-blood coagulation, common pathway12706644
GO:0072378IDA-blood coagulation, fibrin clot formation16846481
GO:0090277IDA-positive regulation of peptide hormone secretion19193866
GO:1900026NAS-positive regulation of substrate adhesion-dependent cell spreading24041635
GO:1902042IDA-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors10903502
GO:2000352IDA-negative regulation of endothelial cell apoptotic process10903502
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FGACDH510743811900554 Reconstituted Complex
FGACDH510853411900554 Reconstituted Complex
FGAF21085341587268 Co-crystal Structure
FGAF21084471587268 Co-crystal Structure
FGAF13A110853410956659 Co-crystal Structure
FGAF13A110846010956659 Co-crystal Structure
NID1FGA1108761680863 Reconstituted Complex
NID1FGA1085341680863 Reconstituted Complex
PLATFGA1113433088041 11170397 Reconstituted Complex
PLATFGA1085343088041 11170397 Reconstituted Complex
HRGFGA1095099276466 Reconstituted Complex
HRGFGA1085349276466 Reconstituted Complex
FGAFGA1085349689040 Co-crystal Structure
THBS1FGA1085349867861 Reconstituted Complex
THBS1FGA1129159867861 Reconstituted Complex
FGBFGA10853412356313 Co-crystal Structure
FGBFGA10853512356313 Co-crystal Structure
FGGFGA10855712356313 Co-crystal Structure
FGGFGA10853412356313 Co-crystal Structure
BAT2FGA10853414667819 Two-hybrid
BAT2FGA11364614667819 Two-hybrid
KHDRBS2FGA12843617643375 Affinity Capture-MS
KHDRBS2FGA10853417643375 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
FGArs2070016, rs2070022 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1316726
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031010-21'