AutismKB 2.0

Annotation Details for FGF2


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Basic Information Top
Gene Symbol:FGF2 ( BFGF,FGFB,HBGF-2 )
Gene Full Name: fibroblast growth factor 2 (basic)
Band: 4q28.1
Quick LinksEntrez ID:2247; OMIM: 134920; Uniprot ID:FGF2_HUMAN; ENSEMBL ID: ENSG00000138685; HGNC ID: 3676
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space2161540
GO:0005634IEA-nucleus-
GO ID Evidence Qualifier GO_term References
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005104IPI-fibroblast growth factor receptor binding2161540
GO:0005125IDA-cytokine activity18059339
GO:0005515IPI-protein binding10490103
GO:0008083IDA-growth factor activity18059339
GO:0008201IEA-heparin binding-
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0030374IDA-ligand-dependent nuclear receptor transcription coactivator activity17500071
GO:0042056IDA-chemoattractant activity18059339
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0090722IDA-receptor-receptor interaction24157794
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000187TAS-activation of MAPK activity9712850
GO:0001658IDA-branching involved in ureteric bud morphogenesis12631064
GO:0001938IDA-positive regulation of endothelial cell proliferation16756958
GO:0001938IMP-positive regulation of endothelial cell proliferation18059339
GO:0002042IDA-cell migration involved in sprouting angiogenesis18059339
GO:0002042IGI-cell migration involved in sprouting angiogenesis19351956
GO:0006661IDA-phosphatidylinositol biosynthetic process20011604
GO:0006935TAS-chemotaxis10848592
GO:0007165NAS-signal transduction9712850
GO:0007265TAS-Ras protein signal transduction10848592
GO:0007399TAS-nervous system development9576942
GO:0008284IDA-positive regulation of cell proliferation2161540
GO:0008284IGI-positive regulation of cell proliferation8663044
GO:0008543IDA-fibroblast growth factor receptor signaling pathway17500071
GO:0008543IGI-fibroblast growth factor receptor signaling pathway2161540
GO:0008543IPI-fibroblast growth factor receptor signaling pathway10830168
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0009887TAS-animal organ morphogenesis10903182
GO:0010764IDA-negative regulation of fibroblast migration19577615
GO:0010863IDA-positive regulation of phospholipase C activity20011604
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014843IMP-growth factor dependent regulation of skeletal muscle satellite cell proliferation18602469
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030198TAS-extracellular matrix organization-
GO:0030214IDA-hyaluronan catabolic process19577615
GO:0032958IDA-inositol phosphate biosynthetic process20011604
GO:0035019TAS-somatic stem cell population maintenance-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0042060IDA-wound healing16756958
GO:0042060TAS-wound healing20011604
GO:0042660IDA-positive regulation of cell fate specification18635606
GO:0043406IDA-positive regulation of MAP kinase activity16756958
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration18555217
GO:0043537IDA-negative regulation of blood vessel endothelial cell migration18555217
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043552IDA-positive regulation of phosphatidylinositol 3-kinase activity20011604
GO:0045765TAS-regulation of angiogenesis20011604
GO:0045766IDA-positive regulation of angiogenesis20011604
GO:0045893IDA-positive regulation of transcription, DNA-templated17500071
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter18059339
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048598TAS-embryonic morphogenesis20011604
GO:0050918IEA-positive chemotaxis-
GO:0051209IDA-release of sequestered calcium ion into cytosol20011604
GO:0051781IEA-positive regulation of cell division-
GO:0060045IDA-positive regulation of cardiac muscle cell proliferation9553078
GO:0060548IDA-negative regulation of cell death12631064
GO:0060591IDA-chondroblast differentiation17167778
GO:0061045IDA-negative regulation of wound healing19577615
GO:0070374IC-positive regulation of ERK1 and ERK2 cascade16756958
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade17167778
GO:0072089NAS-stem cell proliferation25640183
GO:1903672IDA-positive regulation of sprouting angiogenesis16756958
GO:1903672IMP-positive regulation of sprouting angiogenesis23469107
GO:2000544IDA-regulation of endothelial cell chemotaxis to fibroblast growth factor16756958
GO:2000546IDA-positive regulation of endothelial cell chemotaxis to fibroblast growth factor16756958
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FGF2CSNK2A110784112145206 Biochemical Activity; Reconstituted Complex
FGF2CSNK2A110853812145206 Biochemical Activity; Reconstituted Complex
FGF2CSNK2A210784212145206 Reconstituted Complex
FGF2CSNK2A210853812145206 Reconstituted Complex
FGF2CSNK2B10853812145206 Reconstituted Complex
FGF2CSNK2B10784312145206 Reconstituted Complex
FGF2GPC410853011066092 Reconstituted Complex
FGF2GPC410853811066092 Reconstituted Complex
SDC3FGF21085388344959 Reconstituted Complex
SDC3FGF21150278344959 Reconstituted Complex
RPL6FGF21120489826564 Reconstituted Complex; Two-hybrid
RPL6FGF21085389826564 Reconstituted Complex; Two-hybrid
FGFR1FGF210855110950949 Reconstituted Complex
FGFR1FGF210853810950949 Reconstituted Complex
FGFBP1FGF211530411509569 Reconstituted Complex
FGFBP1FGF210853811509569 Reconstituted Complex
RPS19FGF211213711716516 Co-purification; Reconstituted Complex
RPS19FGF210853811716516 Co-purification; Reconstituted Complex
VTNFGF211328711796824 Reconstituted Complex
VTNFGF210853811796824 Reconstituted Complex
GPC3FGF210853812478660 Affinity Capture-Western
GPC3FGF210898312478660 Affinity Capture-Western
SDC1FGF211228416982797 Co-purification
SDC1FGF210853816982797 Co-purification
SDC2FGF211228516982797 Co-purification
SDC2FGF210853816982797 Co-purification
SDC4FGF211228616982797 Co-purification
SDC4FGF210853816982797 Co-purification
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
FGF2rs1048201, rs308402, rs308418 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
FGF2rs10452197, rs12506776, rs308379, rs308420, rs308428, rs308439, rs7700205 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95516
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040318-1'