AutismKB 2.0

Annotation Details for FGF9


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Basic Information Top
Gene Symbol:FGF9 ( GAF,HBFG-9,MGC119914,MGC119915,SYNS3 )
Gene Full Name: fibroblast growth factor 9 (glia-activating factor)
Band: 13q12.11
Quick LinksEntrez ID:2254; OMIM: 600921; Uniprot ID:FGF9_HUMAN; ENSEMBL ID: ENSG00000102678; HGNC ID: 3687
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005604IEA-basement membrane-
GO:0005615IDA-extracellular space8321227
GO:0005737IEA-cytoplasm-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005104IEA-fibroblast growth factor receptor binding-
GO:0008083IEA-growth factor activity-
GO:0008201IEA-heparin binding-
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0000165TAS-MAPK cascade-
GO:0001525IEA-angiogenesis-
GO:0001649IEA-osteoblast differentiation-
GO:0001654IEA-eye development-
GO:0002053IEA-positive regulation of mesenchymal cell proliferation-
GO:0002062IEA-chondrocyte differentiation-
GO:0006606IEA-protein import into nucleus-
GO:0007165TAS-signal transduction8575785
GO:0007267IEA-cell-cell signaling-
GO:0008284IDA-positive regulation of cell proliferation8321227
GO:0008543IGI-fibroblast growth factor receptor signaling pathway8663044
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0008584IEP-male gonad development17848411
GO:0010628IEA-positive regulation of gene expression-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0021762IEP-substantia nigra development22926577
GO:0030178IEA-negative regulation of Wnt signaling pathway-
GO:0030238IEA-male sex determination-
GO:0030326IEA-embryonic limb morphogenesis-
GO:0030949IEA-positive regulation of vascular endothelial growth factor receptor signaling pathway-
GO:0032927IEA-positive regulation of activin receptor signaling pathway-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0042472IEA-inner ear morphogenesis-
GO:0043410IEA-positive regulation of MAPK cascade-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045880IEA-positive regulation of smoothened signaling pathway-
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048505IEA-regulation of timing of cell differentiation-
GO:0048566IEA-embryonic digestive tract development-
GO:0048706IEA-embryonic skeletal system development-
GO:0050679IEA-positive regulation of epithelial cell proliferation-
GO:0051781IEA-positive regulation of cell division-
GO:0060045IEA-positive regulation of cardiac muscle cell proliferation-
GO:0060484IEA-lung-associated mesenchyme development-
GO:0090263IEA-positive regulation of canonical Wnt signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FGFR3FGF91085458576175 10574949 Affinity Capture-Western; Reconstituted Complex
FGFR3FGF91085528576175 10574949 Affinity Capture-Western; Reconstituted Complex
FGF9FGF910854511223514 Co-crystal Structure
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104723
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018