Gene Symbol:	FGFR1 ( BFGFR,CD331,CEK,FGFBR,FLG,FLJ99988,FLT2,HBGFR,KAL2,N-SAM,OGD )
Gene Full Name:	fibroblast growth factor receptor 1
Band:	8p11.23
Quick Links	Entrez ID:2260; OMIM: 136350; Uniprot ID:FGFR1_HUMAN; ENSEMBL ID: ENSG00000077782; HGNC ID: 3688
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	NAS	-	extracellular region	1652059
GO:0005730	IDA	-	nucleolus	-
GO:0005829	IEA	-	cytosol	-
GO:0005886	IDA	-	plasma membrane	18480409
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	TAS	-	integral component of plasma membrane	10918587
GO:0016021	NAS	-	integral component of membrane	1652059
GO:0031410	IEA	-	cytoplasmic vesicle	-
GO:0043235	IDA	-	receptor complex	23382219

GO ID	Evidence	Qualifier	GO_term	References
GO:0004713	IDA	-	protein tyrosine kinase activity	8622701
GO:0004713	TAS	-	protein tyrosine kinase activity	-
GO:0005007	IDA	-	fibroblast growth factor-activated receptor activity	18480409
GO:0005007	TAS	-	fibroblast growth factor-activated receptor activity	2167437
GO:0005088	TAS	-	Ras guanyl-nucleotide exchange factor activity	-
GO:0005515	IPI	-	protein binding	1656221
GO:0005524	IEA	-	ATP binding	-
GO:0008201	IDA	-	heparin binding	18480409
GO:0016303	TAS	-	1-phosphatidylinositol-3-kinase activity	-
GO:0017134	IDA	-	fibroblast growth factor binding	8663044
GO:0042802	IPI	-	identical protein binding	19696444
GO:0042803	IPI	-	protein homodimerization activity	20133753
GO:0046934	TAS	-	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-
GO:0090722	IDA	-	receptor-receptor interaction	24157794

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IEA	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0000165	TAS	-	MAPK cascade	-
GO:0001501	TAS	-	skeletal system development	7874169
GO:0001525	IEA	-	angiogenesis	-
GO:0001657	IEA	-	ureteric bud development	-
GO:0001701	IEA	-	in utero embryonic development	-
GO:0001759	IEA	-	organ induction	-
GO:0001764	TAS	-	neuron migration	15863030
GO:0002053	IEA	-	positive regulation of mesenchymal cell proliferation	-
GO:0002062	IEA	-	chondrocyte differentiation	-
GO:0006351	IEA	-	transcription, DNA-templated	-
GO:0006468	NAS	-	protein phosphorylation	1846977
GO:0007037	IEA	-	vacuolar phosphate transport	-
GO:0007605	IEA	-	sensory perception of sound	-
GO:0008284	IDA	-	positive regulation of cell proliferation	8663044
GO:0008284	IGI	-	positive regulation of cell proliferation	8663044
GO:0008284	IMP	-	positive regulation of cell proliferation	8622701
GO:0008543	IDA	-	fibroblast growth factor receptor signaling pathway	8663044
GO:0008543	IGI	-	fibroblast growth factor receptor signaling pathway	8663044
GO:0008543	IPI	-	fibroblast growth factor receptor signaling pathway	10830168
GO:0008543	TAS	-	fibroblast growth factor receptor signaling pathway	22235191
GO:0010518	TAS	-	positive regulation of phospholipase activity	12141425
GO:0010863	IDA	-	positive regulation of phospholipase C activity	18480409
GO:0010976	IEA	-	positive regulation of neuron projection development	-
GO:0014066	TAS	-	regulation of phosphatidylinositol 3-kinase signaling	-
GO:0014068	TAS	-	positive regulation of phosphatidylinositol 3-kinase signaling	15863030
GO:0016477	TAS	-	cell migration	15863030
GO:0018108	IDA	-	peptidyl-tyrosine phosphorylation	8622701
GO:0021847	IEA	-	ventricular zone neuroblast division	-
GO:0030326	IEA	-	embryonic limb morphogenesis	-
GO:0030901	IEA	-	midbrain development	-
GO:0035607	IEA	-	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	-
GO:0036092	IEA	-	phosphatidylinositol-3-phosphate biosynthetic process	-
GO:0042472	IEA	-	inner ear morphogenesis	-
GO:0042473	IEA	-	outer ear morphogenesis	-
GO:0042474	IEA	-	middle ear morphogenesis	-
GO:0043009	TAS	-	chordate embryonic development	15863030
GO:0043406	IDA	-	positive regulation of MAP kinase activity	8622701
GO:0043410	IMP	-	positive regulation of MAPK cascade	8622701
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0045595	TAS	-	regulation of cell differentiation	12141425
GO:0045666	IMP	-	positive regulation of neuron differentiation	8622701
GO:0046777	IDA	-	protein autophosphorylation	8622701
GO:0046854	IEA	-	phosphatidylinositol phosphorylation	-
GO:0048015	TAS	-	phosphatidylinositol-mediated signaling	12141425
GO:0048339	IEA	-	paraxial mesoderm development	-
GO:0048378	IEA	-	regulation of lateral mesodermal cell fate specification	-
GO:0048469	IEA	-	cell maturation	-
GO:0048705	TAS	-	skeletal system morphogenesis	15863030
GO:0048762	IEA	-	mesenchymal cell differentiation	-
GO:0060045	IEA	-	positive regulation of cardiac muscle cell proliferation	-
GO:0060117	IEA	-	auditory receptor cell development	-
GO:0060445	IEA	-	branching involved in salivary gland morphogenesis	-
GO:0060484	IEA	-	lung-associated mesenchyme development	-
GO:0060665	IEA	-	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	-
GO:0070640	IEA	-	vitamin D3 metabolic process	-
GO:0090080	IEA	-	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	-
GO:0090272	IEA	-	negative regulation of fibroblast growth factor production	-
GO:1903465	IEA	-	positive regulation of mitotic cell cycle DNA replication	-
GO:2000546	IDA	-	positive regulation of endothelial cell chemotaxis to fibroblast growth factor	21885851
GO:2000830	IEA	-	positive regulation of parathyroid hormone secretion	-
GO:2001239	IEA	-	regulation of extrinsic apoptotic signaling pathway in absence of ligand	-

Gene Symbol	Interactant	Interaction ID	References	Description
FGFR1	BNIP2	107131	10551883	Biochemical Activity
FGFR1	BNIP2	108551	10551883	Biochemical Activity
FGFR1	CREBBP	107777	15929978	Affinity Capture-Western
FGFR1	CREBBP	108551	15929978	Affinity Capture-Western
FGFR1	FDPS	108551	12020352	Reconstituted Complex; Two-hybrid
FGFR1	FDPS	108517	12020352	Reconstituted Complex; Two-hybrid
FGFR1	FGF1	108551	8576175 11030354	Co-crystal Structure; Reconstituted Complex
FGFR1	FGF1	108537	8576175 11030354	Co-crystal Structure; Reconstituted Complex
FGFR1	FGF2	108551	10950949	Reconstituted Complex
FGFR1	FGF2	108538	10950949	Reconstituted Complex
SHB	FGFR1	112358	7537362	Affinity Capture-Western; Reconstituted Complex
SHB	FGFR1	108551	7537362	Affinity Capture-Western; Reconstituted Complex
FRS2	FGFR1	116031	9660748 10629055 11090629 11877385	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
FRS2	FGFR1	108551	9660748 10629055 11090629 11877385	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
FRS3	FGFR1	116030	9660748	Two-hybrid
FRS3	FGFR1	108551	9660748	Two-hybrid
PLCG1	FGFR1	108551	9660748	Two-hybrid
PLCG1	FGFR1	111351	9660748	Two-hybrid
GRB14	FGFR1	108551	10713090	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRB14	FGFR1	109145	10713090	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FGFR1	FGFR1	108551	11030354	Reconstituted Complex
KPNB1	FGFR1	108551	11257130	Affinity Capture-Western
KPNB1	FGFR1	110035	11257130	Affinity Capture-Western
NCAM1	FGFR1	110764	12121226	Affinity Capture-Western
NCAM1	FGFR1	108551	12121226	Affinity Capture-Western
UBC	FGFR1	113164	16091423	Affinity Capture-Western
UBC	FGFR1	108551	16091423	Affinity Capture-Western
STAT3	FGFR1	108551	20388777	Affinity Capture-MS; Affinity Capture-Western
STAT3	FGFR1	112651	20388777	Affinity Capture-MS; Affinity Capture-Western
JAK2	FGFR1	109920	20388777	Affinity Capture-Western
JAK2	FGFR1	108551	20388777	Affinity Capture-Western
SRC	FGFR1	112592	20388777	Affinity Capture-Western
SRC	FGFR1	108551	20388777	Affinity Capture-Western

Gene Symbol	Interactant	Interaction ID	References	Description
RPS6KA1	FGFR1	215060	15117958	FGFR1 interacts with RSK1. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RSK1.
TENC1	FGFR1	259651	15117958	An unspecified isoform of FGFR1 interacts with KIAA1075. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human KIAA1075.
PLCG1	FGFR1	259650	15117958	An unspecified isoform of FGFR1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human PLC-gamma.
SH3BP2	FGFR1	259649	15117958	An unspecified isoform of FGFR1 interacts with SH3BP2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human SH3BP2.
NCK2	FGFR1	259648	15117958	An unspecified isoform of FGFR1 interacts with NCK2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human NCK2.
PIK3R2	FGFR1	259653	15117958	An unspecified isoform of FGFR1 interacts with p85-beta. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human p85-beta.
RTN3	FGFR1	259654	15117958	An unspecified isoform of FGFR1 interacts with RTN3. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RTN3.
SLA	FGFR1	259652	15117958	An unspecified isoform of FGFR1 interacts with SLAP. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human SLAP.
RTN1	FGFR1	259656	15117958	An unspecified isoform of FGFR1 interacts with RTN1. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RTN1.

AutismKB 2.0

Annotation Details for FGFR1