AutismKB 2.0

Annotation Details for FGFR2


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Basic Information Top
Gene Symbol:FGFR2 ( BEK,BFR-1,CD332,CEK3,CFD1,ECT1,FLJ98662,JWS,K-SAM,KGFR,TK14,TK25 )
Gene Full Name: fibroblast growth factor receptor 2
Band: 10q26.13
Quick LinksEntrez ID:2263; OMIM: 176943; Uniprot ID:FGFR2_HUMAN; ENSEMBL ID: ENSG00000066468; HGNC ID: 3689
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16597614
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm16597614
GO:0005794IEA-Golgi apparatus-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane15629145
GO:0005938IDA-cell cortex17471512
GO:0009986IDA-cell surface16597614
GO:0016020NAS-membrane8676562
GO:0016021NAS-integral component of membrane1697263
GO:0031012IDAcolocalizes_withextracellular matrix17959718
GO:0031410IEA-cytoplasmic vesicle-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0060076ISS-excitatory synapse-
GO ID Evidence Qualifier GO_term References
GO:0004713NAS-protein tyrosine kinase activity1697263
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005007IDA-fibroblast growth factor-activated receptor activity8663044
GO:0005007IGI-fibroblast growth factor-activated receptor activity10830168
GO:0005007NAS-fibroblast growth factor-activated receptor activity1400433
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding1309608
GO:0005524IEA-ATP binding-
GO:0008201IEA-heparin binding-
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0017134IDA-fibroblast growth factor binding8663044
GO:0017134IPI-fibroblast growth factor binding8386828
GO:0042803IPI-protein homodimerization activity16844695
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0000165TAS-MAPK cascade-
GO:0001525ISS-angiogenesis-
GO:0001657ISS-ureteric bud development-
GO:0001701ISS-in utero embryonic development-
GO:0001837IEA-epithelial to mesenchymal transition-
GO:0002053ISS-positive regulation of mesenchymal cell proliferation-
GO:0003148ISS-outflow tract septum morphogenesis-
GO:0003149ISS-membranous septum morphogenesis-
GO:0003416IEA-endochondral bone growth-
GO:0006915IEA-apoptotic process-
GO:0007267ISS-cell-cell signaling-
GO:0007409ISS-axonogenesis-
GO:0008284IDA-positive regulation of cell proliferation8663044
GO:0008284IGI-positive regulation of cell proliferation8663044
GO:0008284IMP-positive regulation of cell proliferation15629145
GO:0008543IDA-fibroblast growth factor receptor signaling pathway8663044
GO:0008543IGI-fibroblast growth factor receptor signaling pathway8663044
GO:0008543IPI-fibroblast growth factor receptor signaling pathway10830168
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0008589ISS-regulation of smoothened signaling pathway-
GO:0009791ISS-post-embryonic development-
GO:0009880ISS-embryonic pattern specification-
GO:0009887ISS-animal organ morphogenesis-
GO:0010453ISS-regulation of cell fate commitment-
GO:0010518IMP-positive regulation of phospholipase activity16844695
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0016331ISS-morphogenesis of embryonic epithelium-
GO:0018108IDA-peptidyl-tyrosine phosphorylation15629145
GO:0021769ISS-orbitofrontal cortex development-
GO:0021847ISS-ventricular zone neuroblast division-
GO:0021860ISS-pyramidal neuron development-
GO:0022612ISS-gland morphogenesis-
GO:0030177ISS-positive regulation of Wnt signaling pathway-
GO:0030282ISS-bone mineralization-
GO:0030324ISS-lung development-
GO:0030855ISS-epithelial cell differentiation-
GO:0030901ISS-midbrain development-
GO:0030916ISS-otic vesicle formation-
GO:0031069ISS-hair follicle morphogenesis-
GO:0032496IEA-response to lipopolysaccharide-
GO:0032808ISS-lacrimal gland development-
GO:0033688TAS-regulation of osteoblast proliferation15190072
GO:0035264ISS-multicellular organism growth-
GO:0035265ISS-organ growth-
GO:0035602ISS-fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow-
GO:0035603ISS-fibroblast growth factor receptor signaling pathway involved in hemopoiesis-
GO:0035604ISS-fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow-
GO:0035607ISS-fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0040014ISS-regulation of multicellular organism growth-
GO:0040036ISS-regulation of fibroblast growth factor receptor signaling pathway-
GO:0042060IEA-wound healing-
GO:0042472ISS-inner ear morphogenesis-
GO:0042476ISS-odontogenesis-
GO:0043410IMP-positive regulation of MAPK cascade15629145
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045165ISS-cell fate commitment-
GO:0045471IEA-response to ethanol-
GO:0045667TAS-regulation of osteoblast differentiation15190072
GO:0045787ISS-positive regulation of cell cycle-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046777IDA-protein autophosphorylation15629145
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048286ISS-lung alveolus development-
GO:0048333IEA-mesodermal cell differentiation-
GO:0048557ISS-embryonic digestive tract morphogenesis-
GO:0048562ISS-embryonic organ morphogenesis-
GO:0048565ISS-digestive tract development-
GO:0048568ISS-embryonic organ development-
GO:0048608ISS-reproductive structure development-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0048701IMP-embryonic cranial skeleton morphogenesis7874170
GO:0048705TAS-skeletal system morphogenesis15190072
GO:0048730ISS-epidermis morphogenesis-
GO:0048755ISS-branching morphogenesis of a nerve-
GO:0048762ISS-mesenchymal cell differentiation-
GO:0050679ISS-positive regulation of epithelial cell proliferation-
GO:0050680IEA-negative regulation of epithelial cell proliferation-
GO:0051150ISS-regulation of smooth muscle cell differentiation-
GO:0051781ISS-positive regulation of cell division-
GO:0055010ISS-ventricular cardiac muscle tissue morphogenesis-
GO:0060045ISS-positive regulation of cardiac muscle cell proliferation-
GO:0060174ISS-limb bud formation-
GO:0060348ISS-bone development-
GO:0060349ISS-bone morphogenesis-
GO:0060442ISS-branching involved in prostate gland morphogenesis-
GO:0060445ISS-branching involved in salivary gland morphogenesis-
GO:0060449ISS-bud elongation involved in lung branching-
GO:0060463ISS-lung lobe morphogenesis-
GO:0060484ISS-lung-associated mesenchyme development-
GO:0060501ISS-positive regulation of epithelial cell proliferation involved in lung morphogenesis-
GO:0060512ISS-prostate gland morphogenesis-
GO:0060523ISS-prostate epithelial cord elongation-
GO:0060527ISS-prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis-
GO:0060529ISS-squamous basal epithelial stem cell differentiation involved in prostate gland acinus development-
GO:0060595ISS-fibroblast growth factor receptor signaling pathway involved in mammary gland specification-
GO:0060601ISS-lateral sprouting from an epithelium-
GO:0060615ISS-mammary gland bud formation-
GO:0060664ISS-epithelial cell proliferation involved in salivary gland morphogenesis-
GO:0060667ISS-branch elongation involved in salivary gland morphogenesis-
GO:0060670ISS-branching involved in labyrinthine layer morphogenesis-
GO:0060687ISS-regulation of branching involved in prostate gland morphogenesis-
GO:0060688ISS-regulation of morphogenesis of a branching structure-
GO:0060915ISS-mesenchymal cell differentiation involved in lung development-
GO:0060916ISS-mesenchymal cell proliferation involved in lung development-
GO:0070372ISS-regulation of ERK1 and ERK2 cascade-
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0071300IEA-cellular response to retinoic acid-
GO:0071560IEA-cellular response to transforming growth factor beta stimulus-
GO:0090263ISS-positive regulation of canonical Wnt signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FGFR2FGF11085548576175 10618369 11069186 Co-crystal Structure; Reconstituted Complex
FGFR2FGF11085378576175 10618369 11069186 Co-crystal Structure; Reconstituted Complex
FGFR2FGF71085439582367 Reconstituted Complex
FGFR2FGF71085549582367 Reconstituted Complex
FGFR2FGF101085469582367 Reconstituted Complex
FGFR2FGF101085549582367 Reconstituted Complex
FGFR2FGFR210855411069186 Co-crystal Structure
ITGA5FGFR210988415728256 Affinity Capture-Western
ITGA5FGFR210855415728256 Affinity Capture-Western
PIK3R1FGFR210855418374639 Affinity Capture-Western
PIK3R1FGFR211131318374639 Affinity Capture-Western
STAT3FGFR210855420388777 Affinity Capture-Western
STAT3FGFR211265120388777 Affinity Capture-Western
PGRFGFR211126021464042 Affinity Capture-Western
PGRFGFR210855421464042 Affinity Capture-Western
STAT5AFGFR211265321464042 Affinity Capture-Western
STAT5AFGFR210855421464042 Affinity Capture-Western
STAT5BFGFR211265421464042 Affinity Capture-Western
STAT5BFGFR210855421464042 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
FGFR2rs1047057, rs1047100, rs1613776, rs1649161, rs2912779, rs2912787, rs2981428, rs3135758, rs4412700, rs4752496, rs7085142, rs7090018 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95523
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030323-1'