AutismKB 2.0

Annotation Details for FGFR4


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Basic Information Top
Gene Symbol:FGFR4 ( CD334,JTK2,MGC20292,TKF )
Gene Full Name: fibroblast growth factor receptor 4
Band: 5q35.2
Quick LinksEntrez ID:2264; OMIM: 134935; Uniprot ID:FGFR4_HUMAN; ENSEMBL ID: ENSG00000160867; HGNC ID: 3691
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005768IEA-endosome-
GO:0005783IDA-endoplasmic reticulum20683963
GO:0005794IDA-Golgi apparatus18061161
GO:0005886IDA-plasma membrane18061161
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane20683963
GO:0005911IDAcolocalizes_withcell-cell junction20798051
GO:0030133IDA-transport vesicle18061161
GO ID Evidence Qualifier GO_term References
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005007IDA-fibroblast growth factor-activated receptor activity8663044
GO:0005007IGI-fibroblast growth factor-activated receptor activity10525310
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding17627937
GO:0005524IEA-ATP binding-
GO:0008201IDA-heparin binding18480409
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0017134IDA-fibroblast growth factor binding8663044
GO:0017134IPI-fibroblast growth factor binding10525310
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0008284IDA-positive regulation of cell proliferation8663044
GO:0008284IGI-positive regulation of cell proliferation8663044
GO:0008543IDA-fibroblast growth factor receptor signaling pathway21653700
GO:0008543IGI-fibroblast growth factor receptor signaling pathway8663044
GO:0008543IPI-fibroblast growth factor receptor signaling pathway10525310
GO:0008543TAS-fibroblast growth factor receptor signaling pathway-
GO:0010628IMP-positive regulation of gene expression19085950
GO:0010715IMP-regulation of extracellular matrix disassembly20876804
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0016477IMP-cell migration20876804
GO:0018108IDA-peptidyl-tyrosine phosphorylation18480409
GO:0019216ISS-regulation of lipid metabolic process-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0042593ISS-glucose homeostasis-
GO:0043085IMP-positive regulation of catalytic activity20798051
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045862IMP-positive regulation of proteolysis20798051
GO:0046777IDA-protein autophosphorylation20798051
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0055062ISS-phosphate ion homeostasis-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade21653700
GO:0070857IMP-regulation of bile acid biosynthetic process17623664
GO:1903412IMPNOTresponse to bile acid19085950
GO:2000188ISS-regulation of cholesterol homeostasis-
GO:2000573IMP-positive regulation of DNA biosynthetic process21653700
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FGFR4FGF110855510336501 10736564 Reconstituted Complex
FGFR4FGF110853710336501 10736564 Reconstituted Complex
FGF19FGFR410855510525310 Reconstituted Complex
FGF19FGFR411529010525310 Reconstituted Complex
UBCFGFR411316416091423 Affinity Capture-Western
UBCFGFR410855516091423 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
FGFR4rs451643 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95525
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-488'