AutismKB 2.0

Annotation Details for FHL2


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Basic Information Top
Gene Symbol:FHL2 ( AAG11,DRAL,FHL-2,SLIM-3,SLIM3 )
Gene Full Name: four and a half LIM domains 2
Band: 2q12.2
Quick LinksEntrez ID:2274; OMIM: 602633; Uniprot ID:FHL2_HUMAN; ENSEMBL ID: ENSG00000115641; HGNC ID: 3703
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus9150430
GO:0005654TAS-nucleoplasm-
GO:0005925IDA-focal adhesion21423176
GO:0030018IEA-Z disc-
GO:0031430IEA-M band-
GO ID Evidence Qualifier GO_term References
GO:0003713NAS-transcription coactivator activity15572661
GO:0005515IPI-protein binding14550570
GO:0008134IPI-transcription factor binding15692560
GO:0042802IPI-identical protein binding10906324
GO:0046872IEA-metal ion binding-
GO:0050681NAS-androgen receptor binding15572661
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter15692560
GO:0001649IEA-osteoblast differentiation-
GO:0006351IEA-transcription, DNA-templated-
GO:0009725IMP-response to hormone17975004
GO:0019216TAS-regulation of lipid metabolic process-
GO:0030521NAS-androgen receptor signaling pathway15572661
GO:0043066IDA-negative regulation of apoptotic process15692560
GO:0045893NAS-positive regulation of transcription, DNA-templated15572661
GO:0055014IEA-atrial cardiac muscle cell development-
GO:0055015IEA-ventricular cardiac muscle cell development-
GO:0060347IEA-heart trabecula formation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FHL2AK110856512432079 Reconstituted Complex
FHL2AK110670612432079 Reconstituted Complex
FHL2AR10856510654935 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2AR10686210654935 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2BMPR210712719265191 Affinity Capture-Western; Two-hybrid
FHL2BMPR210856519265191 Affinity Capture-Western; Two-hybrid
FHL2BRCA110856514550570 14986435 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2BRCA110714014550570 14986435 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2RUNX110856518768464 Affinity Capture-Western
FHL2RUNX110730918768464 Affinity Capture-Western
FHL2CKM10856512432079 Reconstituted Complex
FHL2CKM10757812432079 Reconstituted Complex
FHL2CREB110856511046156 Affinity Capture-Western; Two-hybrid
FHL2CREB110777511046156 Affinity Capture-Western; Two-hybrid
FHL2CTNNB110788012466281 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2CTNNB110856512466281 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2E2F110820112411495 Two-hybrid
FHL2E2F110856512411495 Two-hybrid
FHL2E2F210856512411495 Two-hybrid
FHL2E2F210820212411495 Two-hybrid
FHL2E2F310856512411495 Two-hybrid
FHL2E2F310820312411495 Two-hybrid
FHL2E2F410856512411495 Two-hybrid
FHL2E2F410820612411495 Two-hybrid
FHL2FHL110856412432079 Reconstituted Complex
FHL2FHL110856512432079 Reconstituted Complex
MCM7FHL211034410649446 Two-hybrid
MCM7FHL210856510649446 Two-hybrid
ITGA3FHL210856510906324 Affinity Capture-Western; Two-hybrid
ITGA3FHL210988210906324 Affinity Capture-Western; Two-hybrid
ITGB1FHL210989410906324 Affinity Capture-Western; Two-hybrid
ITGB1FHL210856510906324 Affinity Capture-Western; Two-hybrid
ITGB2FHL210989510906324 Affinity Capture-Western; Two-hybrid
ITGB2FHL210856510906324 Affinity Capture-Western; Two-hybrid
EIF6FHL210856510906324 Affinity Capture-Western; Two-hybrid
EIF6FHL210989810906324 Affinity Capture-Western; Two-hybrid
ITGB6FHL210990010906324 Affinity Capture-Western; Two-hybrid
ITGB6FHL210856510906324 Affinity Capture-Western; Two-hybrid
PSEN2FHL211164311001931 Affinity Capture-Western; Two-hybrid
PSEN2FHL210856511001931 Affinity Capture-Western; Two-hybrid
FHL3FHL210856611046156 11135358 FRET; Two-hybrid
FHL3FHL210856511046156 11135358 FRET; Two-hybrid
FHL2FHL210856511046156 Two-hybrid
SFPQFHL210856511161712 Two-hybrid
SFPQFHL211231911161712 Two-hybrid
ZNF638FHL210856511813260 FRET; Two-hybrid
ZNF638FHL211814511813260 FRET; Two-hybrid
IGFBP5FHL210970911821401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IGFBP5FHL210856511821401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZBTB16FHL210856512145280 Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
ZBTB16FHL211349812145280 Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
PFKMFHL211123412432079 Reconstituted Complex
PFKMFHL210856512432079 Reconstituted Complex
TTNFHL211312412432079 Reconstituted Complex; Two-hybrid
TTNFHL210856512432079 Reconstituted Complex; Two-hybrid
MAPK1FHL211158014729955 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1FHL210856514729955 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITGA7FHL210988515117962 Affinity Capture-Western; Co-localization; Two-hybrid
ITGA7FHL210856515117962 Affinity Capture-Western; Co-localization; Two-hybrid
TRAF6FHL211304118768464 Affinity Capture-Western; Biochemical Activity
TRAF6FHL210856518768464 Affinity Capture-Western; Biochemical Activity
Gene Symbol Interactant Interaction ID References Description
FOXO1FHL221747915692560 FOXO1A interacts with FHL2.
TTNFHL221775612432079 An unspecified isoform of FHL2 (DRAL) interacts with TTN (titin).
SIRT1FHL221766815692560 FHL2 interacts with SIRT1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338762
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040808-49'