AutismKB 2.0

Annotation Details for XRN2


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Basic Information Top
Gene Symbol:XRN2 ( - )
Gene Full Name: 5'-3' exoribonuclease 2
Band: 20p11.22
Quick LinksEntrez ID:22803; OMIM: 608851; Uniprot ID:XRN2_HUMAN; ENSEMBL ID: ENSG00000088930; HGNC ID: 12836
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus12429849
GO:0016020IDA-membrane19946888
GO:0016235IDA-aggresome-
GO ID Evidence Qualifier GO_term References
GO:0000175EXP-3'-5'-exoribonuclease activity23482395
GO:0001147IDA-transcription termination site sequence-specific DNA binding21700224
GO:0003723IDA-RNA binding22658674
GO:0004518TAS-nuclease activity10409438
GO:0004534TAS-5'-3' exoribonuclease activity10409438
GO:0005515IPI-protein binding26700805
GO:0008409IDA-5'-3' exonuclease activity15565158
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000738IDA-DNA catabolic process, exonucleolytic15565158
GO:0006353IEA-DNA-templated transcription, termination-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006364TAS-rRNA processing-
GO:0006396TAS-RNA processing10409438
GO:0006397IEA-mRNA processing-
GO:0006401TAS-RNA catabolic process10409438
GO:0007283IEP-spermatogenesis10409438
GO:0016049ISS-cell growth-
GO:0016070ISS-RNA metabolic process-
GO:0021766IEA-hippocampus development-
GO:0030182IEA-neuron differentiation-
GO:0060041IEA-retina development in camera-type eye-
GO:0090503IEA-RNA phosphodiester bond hydrolysis, exonucleolytic-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:894687
  • Data Attributes: MGI curated and HomoloGene calculated
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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