AutismKB 2.0

Annotation Details for IKZF2


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Basic Information Top
Gene Symbol:IKZF2 ( HELIOS,MGC34330,ZNF1A2,ZNFN1A2 )
Gene Full Name: IKAROS family zinc finger 2 (Helios)
Band: 2q34
Quick LinksEntrez ID:22807; OMIM: 606234; Uniprot ID:IKZF2_HUMAN; ENSEMBL ID: ENSG00000030419; HGNC ID: 13177
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO ID Evidence Qualifier GO_term References
GO:0003674ND-molecular_function-
GO:0003700IBA-transcription factor activity, sequence-specific DNA binding-
GO:0005515IPI-protein binding23088713
GO:0042803IEA-protein homodimerization activity-
GO:0044212IBA-transcription regulatory region DNA binding-
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IBA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006351IEA-transcription, DNA-templated-
GO:0008150ND-biological_process-
GO:0045944IBA-positive regulation of transcription from RNA polymerase II promoter-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IKZF2CHD411648512015313 Affinity Capture-Western
IKZF2CHD410753312015313 Affinity Capture-Western
IKZF2HDAC211648512015313 Affinity Capture-Western
IKZF2HDAC210931612015313 Affinity Capture-Western
IKZF2HDAC411648512943985 Reconstituted Complex
IKZF2HDAC411510612943985 Reconstituted Complex
IKZF2HDAC511533112015313 Affinity Capture-Western
IKZF2HDAC511648512015313 Affinity Capture-Western
IKZF2IKZF11164859560339 Affinity Capture-Western
IKZF2IKZF11156049560339 Affinity Capture-Western
IKZF2IKZF31164849560339 Affinity Capture-Western
IKZF2IKZF31164859560339 Affinity Capture-Western
IKZF2IKZF21164859560339 Affinity Capture-Western
SIN3BIKZF211648512015313 Affinity Capture-Western
SIN3BIKZF211690112015313 Affinity Capture-Western
SIN3AIKZF211648512015313 Affinity Capture-Western
SIN3AIKZF211743912015313 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1342541
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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