AutismKB 2.0

Annotation Details for NLRP1


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Basic Information Top
Gene Symbol:NLRP1 ( CARD7,CLR17.1,DEFCAP,DEFCAP-L/S,DKFZp586O1822,KIAA0926,NAC,NALP1,PP1044,SLEV1,VAMAS1 )
Gene Full Name: NLR family, pyrin domain containing 1
Band: 17p13
Quick LinksEntrez ID:22861; OMIM: 606636; Uniprot ID:NALP1_HUMAN; ENSEMBL ID: ENSG00000091592; HGNC ID: 14374
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IC-intracellular11076957
GO:0005634IDA-nucleus17164409
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0043025IEA-neuronal cell body-
GO:0072558IDA-NLRP1 inflammasome complex12191486
GO:0072558TAS-NLRP1 inflammasome complex20303873
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11472070
GO:0005524IDA-ATP binding15212762
GO:0008656NAS-cysteine-type endopeptidase activator activity involved in apoptotic process11076957
GO:0019899IPI-enzyme binding11076957
GO:0019904IPI-protein domain specific binding16575408
GO:0097110IEA-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0006915NAS-apoptotic process11076957
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process15212762
GO:0006919NAS-activation of cysteine-type endopeptidase activity involved in apoptotic process11076957
GO:0006954IEA-inflammatory response-
GO:0016032IEA-viral process-
GO:0032495ISS-response to muramyl dipeptide-
GO:0042742ISS-defense response to bacterium-
GO:0045087IEA-innate immune response-
GO:0050718ISS-positive regulation of interleukin-1 beta secretion-
GO:0050727IC-regulation of inflammatory response15212762
GO:0051402IDA-neuron apoptotic process15212762
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLRP1APAF110681411113115 Affinity Capture-Western; Co-purification
NLRP1APAF111652911113115 Affinity Capture-Western; Co-purification
NLRP1CASP210728511076957 Affinity Capture-Western
NLRP1CASP211652911076957 Affinity Capture-Western
NLRP1CASP911652911076957 11113115 Affinity Capture-Western
NLRP1CASP910729211076957 11113115 Affinity Capture-Western
NLRC4NLRP112181411472070 Affinity Capture-Western
NLRC4NLRP111652911472070 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
NLRP1CASP121661015107016 NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2684861
  • Data Attributes: MGI curated and HomoloGene calculated
No data