AutismKB 2.0

Annotation Details for NLGN1


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Basic Information Top
Gene Symbol:NLGN1 ( KIAA1070,MGC45115,NL1 )
Gene Full Name: neuroligin 1
Band: 3q26.31
Quick LinksEntrez ID:22871; OMIM: 600568; Uniprot ID:NLGN1_HUMAN; ENSEMBL ID: ENSG00000169760; HGNC ID: 14291
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005794ISS-Golgi apparatus-
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0005887ISS-integral component of plasma membrane-
GO:0009897IEA-external side of plasma membrane-
GO:0009986IBA-cell surface-
GO:0009986ISS-cell surface-
GO:0014069ISScolocalizes_withpostsynaptic density-
GO:0014069TAS-postsynaptic density15797875
GO:0017146IEA-NMDA selective glutamate receptor complex-
GO:0030054IEA-cell junction-
GO:0030425ISS-dendrite-
GO:0032433ISS-filopodium tip-
GO:0043197ISS-dendritic spine-
GO:0043198IEA-dendritic shaft-
GO:0045202ISS-synapse-
GO:0060076IEA-excitatory synapse-
GO:0098793IEA-presynapse-
GO:0099055TAS-integral component of postsynaptic membrane15797875
GO ID Evidence Qualifier GO_term References
GO:0004872IBA-receptor activity-
GO:0004872ISS-receptor activity-
GO:0030165IDA-PDZ domain binding17474715
GO:0042043IBA-neurexin family protein binding-
GO:0042043ISS-neurexin family protein binding-
GO:0046983ISS-protein dimerization activity-
GO:0050839ISS-cell adhesion molecule binding-
GO:0052689IBA-carboxylic ester hydrolase activity-
GO:0097110IDA-scaffold protein binding17474715
GO ID Evidence Qualifier GO_term References
GO:0002087IEA-regulation of respiratory gaseous exchange by neurological system process-
GO:0006605ISS-protein targeting-
GO:0007157ISS-heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-
GO:0007158ISS-neuron cell-cell adhesion-
GO:0007158TAS-neuron cell-cell adhesion15797875
GO:0007399ISS-nervous system development-
GO:0007416ISS-synapse assembly-
GO:0010841ISS-positive regulation of circadian sleep/wake cycle, wakefulness-
GO:0016080ISS-synaptic vesicle targeting-
GO:0016339ISS-calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-
GO:0023041TAS-neuronal signal transduction15797875
GO:0031175IDA-neuron projection development22750515
GO:0032230ISS-positive regulation of synaptic transmission, GABAergic-
GO:0035418ISS-protein localization to synapse-
GO:0045184ISS-establishment of protein localization-
GO:0045664ISS-regulation of neuron differentiation-
GO:0048511IEA-rhythmic process-
GO:0048789ISS-cytoskeletal matrix organization at active zone-
GO:0051260ISS-protein homooligomerization-
GO:0051290IEA-protein heterotetramerization-
GO:0051491ISS-positive regulation of filopodium assembly-
GO:0051965IDA-positive regulation of synapse assembly24613359
GO:0051965ISS-positive regulation of synapse assembly-
GO:0051968ISS-positive regulation of synaptic transmission, glutamatergic-
GO:0060291IEA-long-term synaptic potentiation-
GO:0060999IGI-positive regulation of dendritic spine development23143522
GO:0060999ISS-positive regulation of dendritic spine development-
GO:0061002IGI-negative regulation of dendritic spine morphogenesis23143522
GO:0072553ISS-terminal button organization-
GO:0097091ISS-synaptic vesicle clustering-
GO:0097104ISS-postsynaptic membrane assembly-
GO:0097105ISS-presynaptic membrane assembly-
GO:0097113ISS-AMPA glutamate receptor clustering-
GO:0097114ISS-NMDA glutamate receptor clustering-
GO:0097115ISS-neurexin clustering involved in presynaptic membrane assembly-
GO:0097119ISS-postsynaptic density protein 95 clustering-
GO:0097120ISS-receptor localization to synapse-
GO:0098942IEA-retrograde trans-synaptic signaling by trans-synaptic protein complex-
GO:1900029ISS-positive regulation of ruffle assembly-
GO:1900244ISS-positive regulation of synaptic vesicle endocytosis-
GO:1902474IEA-positive regulation of protein localization to synapse-
GO:1902533ISS-positive regulation of intracellular signal transduction-
GO:1904861IEA-excitatory synapse assembly-
GO:1905520IEA-positive regulation of presynaptic active zone assembly-
GO:2000302ISS-positive regulation of synaptic vesicle exocytosis-
GO:2000310IGI-regulation of NMDA receptor activity23143522
GO:2000310ISS-regulation of NMDA receptor activity-
GO:2000311ISS-regulation of AMPA receptor activity-
GO:2000463IGI-positive regulation of excitatory postsynaptic potential23143522
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
GO:2000809IEA-positive regulation of synaptic vesicle clustering-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLGN1DLG21080849278515 Two-hybrid
NLGN1DLG21165389278515 Two-hybrid
NLGN1DLG31080859278515 Two-hybrid
NLGN1DLG31165389278515 Two-hybrid
NLGN1DLG41165389278515 Reconstituted Complex; Two-hybrid
NLGN1DLG41080869278515 Reconstituted Complex; Two-hybrid
NLGN1NRXN31147708576240 Reconstituted Complex
NLGN1NRXN31165388576240 Reconstituted Complex
NLGN1NRXN11147798576240 14522992 Reconstituted Complex
NLGN1NRXN11165388576240 14522992 Reconstituted Complex
NLGN1NRXN21165388576240 Reconstituted Complex
NLGN1NRXN21147808576240 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2179435
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090918-1'