AutismKB 2.0

Annotation Details for KLRK1


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Basic Information Top
Gene Symbol:KLRK1 ( CD314,D12S2489E,FLJ17759,FLJ75772,KLR,NKG2-D,NKG2D )
Gene Full Name: killer cell lectin-like receptor subfamily K, member 1
Band: 12p13.2
Quick LinksEntrez ID:22914; OMIM: 611817; Uniprot ID:NKG2D_HUMAN; ENSEMBL ID: ENSG00000213809; HGNC ID: 18788
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane2007850
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface10426994
GO:0016021TAS-integral component of membrane9683661
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity2007850
GO:0005515IPI-protein binding10426993
GO:0030246IEA-carbohydrate binding-
GO:0032394IEA-MHC class Ib receptor activity-
GO:0042288IEA-MHC class I protein binding-
GO:0042803IEA-protein homodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0002223IEA-stimulatory C-type lectin receptor signaling pathway-
GO:0002250IEA-adaptive immune response-
GO:0007165TAS-signal transduction2007850
GO:0030101TAS-natural killer cell activation18676862
GO:0030154IEA-cell differentiation-
GO:0031295TAS-T cell costimulation18676862
GO:0032729IEA-positive regulation of interferon-gamma production-
GO:0034260IDA-negative regulation of GTPase activity22585739
GO:0045087IEA-innate immune response-
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045954IDA-positive regulation of natural killer cell mediated cytotoxicity15294961
GO:0050776TAS-regulation of immune response-
GO:0050830IEA-defense response to Gram-positive bacterium-
GO:0071222IEA-cellular response to lipopolysaccharide-
GO:2000502IDA-negative regulation of natural killer cell chemotaxis22585739
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KLRK1RAE111657611520456 Reconstituted Complex
KLRK1RAE111405411520456 Reconstituted Complex
KLRK1HCST11607910426994 Affinity Capture-Western
KLRK1HCST11657610426994 Affinity Capture-Western
No data
Gene Symbol Interactant Interaction ID References Description
KLRK1MICB1724012902493 -
KLRK1MICB0389412902493 -
KLRK1HCST1724010426994 -
KLRK1HCST0497110426994 -
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1196250
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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