Gene Symbol:	SHANK2 ( AUTS17,CORTBP1,CTTNBP1,ProSAP1,SHANK,SPANK-3 )
Gene Full Name:	SH3 and multiple ankyrin repeat domains 2
Band:	11q13.3-q13.4
Quick Links	Entrez ID:22941; OMIM: 603290; Uniprot ID:SHAN2_HUMAN; ENSEMBL ID: ENSG00000162105; HGNC ID: 14295
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0001750	ISS	-	photoreceptor outer segment	-
GO:0001917	ISS	-	photoreceptor inner segment	-
GO:0005575	ND	-	cellular_component	-
GO:0005829	TAS	-	cytosol	-
GO:0005883	ISS	colocalizes_with	neurofilament	-
GO:0005886	ISS	-	plasma membrane	-
GO:0008328	ISS	colocalizes_with	ionotropic glutamate receptor complex	-
GO:0014069	ISS	-	postsynaptic density	-
GO:0016324	ISS	-	apical plasma membrane	-
GO:0030054	IEA	-	cell junction	-
GO:0030426	ISS	-	growth cone	-
GO:0031526	ISS	-	brush border membrane	-
GO:0043005	ISS	-	neuron projection	-
GO:0043025	ISS	-	neuronal cell body	-
GO:0043197	ISS	-	dendritic spine	-
GO:0045211	ISS	colocalizes_with	postsynaptic membrane	-
GO:0060170	ISS	-	ciliary membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	11583995
GO:0017124	IEA	-	SH3 domain binding	-
GO:0030160	NAS	-	GKAP/Homer scaffold activity	10506216
GO:0035255	ISS	-	ionotropic glutamate receptor binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0007416	ISS	-	synapse assembly	22699620
GO:0007612	IMP	-	learning	20473310
GO:0030534	IMP	-	adult behavior	20473310
GO:0035176	IMP	-	social behavior	20473310
GO:0060291	ISS	-	long-term synaptic potentiation	22699620
GO:0060292	ISS	-	long term synaptic depression	22699620
GO:0071625	IMP	-	vocalization behavior	20473310

Gene Symbol	Interactant	Interaction ID	References	Description
SHANK2	DLG4	116598	10527873 10844022	Affinity Capture-Western
SHANK2	DLG4	108086	10527873 10844022	Affinity Capture-Western
SHANK2	DNM2	116598	11583995	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK2	DNM2	108122	11583995	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK2	CTTN	116598	9742101	Affinity Capture-Western; Two-hybrid
SHANK2	CTTN	108332	9742101	Affinity Capture-Western; Two-hybrid
SHANK2	MYO5A	116598	10844022	Affinity Capture-Western
SHANK2	MYO5A	110728	10844022	Affinity Capture-Western
SHANK2	DYNLL1	114206	10844022	Affinity Capture-Western
SHANK2	DYNLL1	116598	10844022	Affinity Capture-Western
SHANK2	ARHGEF7	114393	12626503	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK2	ARHGEF7	116598	12626503	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK2	DLGAP2	114659	10527873	Two-hybrid
SHANK2	DLGAP2	116598	10527873	Two-hybrid
SHANK2	DLGAP1	114660	10527873 10844022	Affinity Capture-Western; Two-hybrid
SHANK2	DLGAP1	116598	10527873 10844022	Affinity Capture-Western; Two-hybrid
SHANK2	DLGAP4	116598	10527873	Two-hybrid
SHANK2	DLGAP4	116513	10527873	Two-hybrid
DLGAP3	SHANK2	116598	10527873	Two-hybrid
DLGAP3	SHANK2	121839	10527873	Two-hybrid
DYNLL2	SHANK2	116598	10844022	Affinity Capture-Western
DYNLL2	SHANK2	126680	10844022	Affinity Capture-Western

AutismKB 2.0

Annotation Details for SHANK2