AutismKB 2.0

Annotation Details for DKK1


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Basic Information Top
Gene Symbol:DKK1 ( DKK-1,SK )
Gene Full Name: dickkopf homolog 1 (Xenopus laevis)
Band: 10q21.1
Quick LinksEntrez ID:22943; OMIM: 605189; Uniprot ID:DKK1_HUMAN; ENSEMBL ID: ENSG00000107984; HGNC ID: 2891
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space11448771
GO:0005886IDA-plasma membrane16263759
GO:0031901TAS-early endosome membrane-
GO ID Evidence Qualifier GO_term References
GO:0004871TAS-signal transducer activity10383463
GO:0005515IPI-protein binding11448771
GO:0008083TAS-growth factor activity10383463
GO:0039706IPI-co-receptor binding11433302
GO:0039706TAS-co-receptor binding22988876
GO:0048019IDA-receptor antagonist activity20723538
GO:0050750IDA-low-density lipoprotein particle receptor binding16263759
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter20723538
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0000904IEA-cell morphogenesis involved in differentiation-
GO:0001706IEA-endoderm formation-
GO:0001707IEA-mesoderm formation-
GO:0001942IEA-hair follicle development-
GO:0002090IDA-regulation of receptor internalization17804805
GO:0007611ISS-learning or memory-
GO:0010628IGI-positive regulation of gene expression23164821
GO:0010628ISS-positive regulation of gene expression-
GO:0010942TAS-positive regulation of cell death23164821
GO:0030178IDA-negative regulation of Wnt signaling pathway22615920
GO:0030279ISS-negative regulation of ossification-
GO:0030326IEA-embryonic limb morphogenesis-
GO:0030514IEA-negative regulation of BMP signaling pathway-
GO:0030900IEA-forebrain development-
GO:0032091IDA-negative regulation of protein binding20093360
GO:0032526IEA-response to retinoic acid-
GO:0033137IDA-negative regulation of peptidyl-serine phosphorylation20723538
GO:0042662IDA-negative regulation of mesodermal cell fate specification20559569
GO:0042663IDA-regulation of endodermal cell fate specification20559569
GO:0043066ISS-negative regulation of apoptotic process-
GO:0043507IDA-positive regulation of JUN kinase activity23164821
GO:0045813TAS-positive regulation of Wnt signaling pathway, calcium modulating pathway23164821
GO:0048642IEA-negative regulation of skeletal muscle tissue development-
GO:0050807IEA-regulation of synapse organization-
GO:0051966IEA-regulation of synaptic transmission, glutamatergic-
GO:0060173ISS-limb development-
GO:0060325IEA-face morphogenesis-
GO:0060394IDA-negative regulation of pathway-restricted SMAD protein phosphorylation20559569
GO:0061743IEA-motor learning-
GO:0090082ISS-positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway-
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway11433302
GO:0090090IGI-negative regulation of canonical Wnt signaling pathway18166153
GO:0090090NAS-negative regulation of canonical Wnt signaling pathway24431302
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway23164821
GO:0090244IEA-Wnt signaling pathway involved in somitogenesis-
GO:0090647ISS-modulation of age-related behavioral decline-
GO:0098883TAS-synapse disassembly24449494
GO:1900116IEA-extracellular negative regulation of signal transduction-
GO:1901216ISS-positive regulation of neuron death-
GO:1901296IDA-negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment20559569
GO:1902949ISS-positive regulation of tau-protein kinase activity-
GO:1904338TAS-regulation of dopaminergic neuron differentiation24431302
GO:1904723IDA-negative regulation of Wnt-Frizzled-LRP5/6 complex assembly11448771
GO:1904723IPI-negative regulation of Wnt-Frizzled-LRP5/6 complex assembly11433302
GO:1904723TAS-negative regulation of Wnt-Frizzled-LRP5/6 complex assembly23164821
GO:1904958IEA-positive regulation of midbrain dopaminergic neuron differentiation-
GO:2000096TAS-positive regulation of Wnt signaling pathway, planar cell polarity pathway23164821
GO:2000726IDA-negative regulation of cardiac muscle cell differentiation20559569
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DKK1LRP611659911448771 Affinity Capture-Western
DKK1LRP611021911448771 Affinity Capture-Western
DKK1MDFI11659916189514 Two-hybrid
DKK1MDFI11035316189514 Two-hybrid
DKK1CORO1A11632217353931 Affinity Capture-MS
DKK1CORO1A11659917353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
DKK1DKK1_Intron 1, rs1881747 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
DKK1rs1528877, rs1569198, rs1896367, rs1896368, rs2288335 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1329040
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090313-406'