Gene Symbol:	DKK1 ( DKK-1,SK )
Gene Full Name:	dickkopf homolog 1 (Xenopus laevis)
Band:	10q21.1
Quick Links	Entrez ID:22943; OMIM: 605189; Uniprot ID:DKK1_HUMAN; ENSEMBL ID: ENSG00000107984; HGNC ID: 2891
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	TAS	-	extracellular region	-
GO:0005615	IDA	-	extracellular space	11448771
GO:0005886	IDA	-	plasma membrane	16263759
GO:0031901	TAS	-	early endosome membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004871	TAS	-	signal transducer activity	10383463
GO:0005515	IPI	-	protein binding	11448771
GO:0008083	TAS	-	growth factor activity	10383463
GO:0039706	IPI	-	co-receptor binding	11433302
GO:0039706	TAS	-	co-receptor binding	22988876
GO:0048019	IDA	-	receptor antagonist activity	20723538
GO:0050750	IDA	-	low-density lipoprotein particle receptor binding	16263759

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IDA	-	negative regulation of transcription from RNA polymerase II promoter	20723538
GO:0000122	ISS	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0000904	IEA	-	cell morphogenesis involved in differentiation	-
GO:0001706	IEA	-	endoderm formation	-
GO:0001707	IEA	-	mesoderm formation	-
GO:0001942	IEA	-	hair follicle development	-
GO:0002090	IDA	-	regulation of receptor internalization	17804805
GO:0007611	ISS	-	learning or memory	-
GO:0010628	IGI	-	positive regulation of gene expression	23164821
GO:0010628	ISS	-	positive regulation of gene expression	-
GO:0010942	TAS	-	positive regulation of cell death	23164821
GO:0030178	IDA	-	negative regulation of Wnt signaling pathway	22615920
GO:0030279	ISS	-	negative regulation of ossification	-
GO:0030326	IEA	-	embryonic limb morphogenesis	-
GO:0030514	IEA	-	negative regulation of BMP signaling pathway	-
GO:0030900	IEA	-	forebrain development	-
GO:0032091	IDA	-	negative regulation of protein binding	20093360
GO:0032526	IEA	-	response to retinoic acid	-
GO:0033137	IDA	-	negative regulation of peptidyl-serine phosphorylation	20723538
GO:0042662	IDA	-	negative regulation of mesodermal cell fate specification	20559569
GO:0042663	IDA	-	regulation of endodermal cell fate specification	20559569
GO:0043066	ISS	-	negative regulation of apoptotic process	-
GO:0043507	IDA	-	positive regulation of JUN kinase activity	23164821
GO:0045813	TAS	-	positive regulation of Wnt signaling pathway, calcium modulating pathway	23164821
GO:0048642	IEA	-	negative regulation of skeletal muscle tissue development	-
GO:0050807	IEA	-	regulation of synapse organization	-
GO:0051966	IEA	-	regulation of synaptic transmission, glutamatergic	-
GO:0060173	ISS	-	limb development	-
GO:0060325	IEA	-	face morphogenesis	-
GO:0060394	IDA	-	negative regulation of pathway-restricted SMAD protein phosphorylation	20559569
GO:0061743	IEA	-	motor learning	-
GO:0090082	ISS	-	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	-
GO:0090090	IDA	-	negative regulation of canonical Wnt signaling pathway	11433302
GO:0090090	IGI	-	negative regulation of canonical Wnt signaling pathway	18166153
GO:0090090	NAS	-	negative regulation of canonical Wnt signaling pathway	24431302
GO:0090090	TAS	-	negative regulation of canonical Wnt signaling pathway	23164821
GO:0090244	IEA	-	Wnt signaling pathway involved in somitogenesis	-
GO:0090647	ISS	-	modulation of age-related behavioral decline	-
GO:0098883	TAS	-	synapse disassembly	24449494
GO:1900116	IEA	-	extracellular negative regulation of signal transduction	-
GO:1901216	ISS	-	positive regulation of neuron death	-
GO:1901296	IDA	-	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	20559569
GO:1902949	ISS	-	positive regulation of tau-protein kinase activity	-
GO:1904338	TAS	-	regulation of dopaminergic neuron differentiation	24431302
GO:1904723	IDA	-	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	11448771
GO:1904723	IPI	-	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	11433302
GO:1904723	TAS	-	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	23164821
GO:1904958	IEA	-	positive regulation of midbrain dopaminergic neuron differentiation	-
GO:2000096	TAS	-	positive regulation of Wnt signaling pathway, planar cell polarity pathway	23164821
GO:2000726	IDA	-	negative regulation of cardiac muscle cell differentiation	20559569

Gene Symbol	Interactant	Interaction ID	References	Description
DKK1	LRP6	116599	11448771	Affinity Capture-Western
DKK1	LRP6	110219	11448771	Affinity Capture-Western
DKK1	MDFI	116599	16189514	Two-hybrid
DKK1	MDFI	110353	16189514	Two-hybrid
DKK1	CORO1A	116322	17353931	Affinity Capture-MS
DKK1	CORO1A	116599	17353931	Affinity Capture-MS

AutismKB 2.0

Annotation Details for DKK1