AutismKB 2.0

Annotation Details for SPEN


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Basic Information Top
Gene Symbol:SPEN ( HIAA0929,KIAA0929,MINT,RBM15C,SHARP )
Gene Full Name: spen homolog, transcriptional regulator (Drosophila)
Band: 1p36.21-p36.13
Quick LinksEntrez ID:23013; OMIM: 613484; Uniprot ID:MINT_HUMAN; ENSEMBL ID: ENSG00000065526; HGNC ID: 17575
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0017053IDA-transcriptional repressor complex16287852
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0001085IPI-RNA polymerase II transcription factor binding16287852
GO:0001191IDA-transcriptional repressor activity, RNA polymerase II transcription factor binding16287852
GO:0003676IBA-nucleic acid binding-
GO:0003677IEA-DNA binding-
GO:0003723IDA-RNA binding22658674
GO:0005515IPI-protein binding16129689
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter16287852
GO:0000398IBA-mRNA splicing, via spliceosome-
GO:0006351IEA-transcription, DNA-templated-
GO:0007219IEA-Notch signaling pathway-
GO:0016032IEA-viral process-
GO:0045892IDA-negative regulation of transcription, DNA-templated16129689
GO:0050769IMP-positive regulation of neurogenesis16287852
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SPENHDAC110931511331609 Affinity Capture-Western; Reconstituted Complex
SPENHDAC111665511331609 Affinity Capture-Western; Reconstituted Complex
SPENRBPJ10973612374742 Reconstituted Complex
SPENRBPJ11665512374742 Reconstituted Complex
SPENPPARD11665511867749 Affinity Capture-Western
SPENPPARD11146311867749 Affinity Capture-Western
SPENNCOR111497312897056 Reconstituted Complex
SPENNCOR111665512897056 Reconstituted Complex
SPENNCOR211665511331609 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPENNCOR211497411331609 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPENSRA111665511331609 Affinity Capture-Western; Reconstituted Complex
SPENSRA111532911331609 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891706
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050309-70'