AutismKB 2.0

Annotation Details for CNOT1


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Basic Information Top
Gene Symbol:CNOT1 ( CDC39,DKFZp686E0722,DKFZp686O168,FLJ36492,FLJ90644,KIAA1007,NOT1,NOT1H )
Gene Full Name: CCR4-NOT transcription complex, subunit 1
Band: 16q21
Quick LinksEntrez ID:23019; OMIM: 604917; Uniprot ID:CNOT1_HUMAN; ENSEMBL ID: ENSG00000125107; HGNC ID: 7877
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body21976065
GO:0000932ISS-P-body-
GO:0005615IDA-extracellular space22664934
GO:0005634IEA-nucleus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0030014IDA-CCR4-NOT complex19558367
GO:0030015IBA-CCR4-NOT core complex-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0004535IDAcontributes_topoly(A)-specific ribonuclease activity21976065
GO:0005515IPI-protein binding10637334
GO:0019904IPI-protein domain specific binding24768540
GO:0030331IDA-estrogen receptor binding16778766
GO:0032947IDA-protein complex scaffold22977175
GO:0042974IDA-retinoic acid receptor binding16778766
GO:0070016IPI-armadillo repeat domain binding24768540
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter16778766
GO:0000289TAS-nuclear-transcribed mRNA poly(A) tail shortening-
GO:0006351IEA-transcription, DNA-templated-
GO:0006977TAS-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-
GO:0007275IEA-multicellular organism development-
GO:0010606IDA-positive regulation of cytoplasmic mRNA processing body assembly21976065
GO:0017148IDA-negative regulation of translation24736845
GO:0033147IDA-negative regulation of intracellular estrogen receptor signaling pathway16778766
GO:0035195IDA-gene silencing by miRNA23172285
GO:0048387IDA-negative regulation of retinoic acid receptor signaling pathway16778766
GO:0060213IDA-positive regulation of nuclear-transcribed mRNA poly(A) tail shortening23644599
GO:0060213IMP-positive regulation of nuclear-transcribed mRNA poly(A) tail shortening21278420
GO:0061014IMP-positive regulation of mRNA catabolic process22977175
GO:0090503IEA-RNA phosphodiester bond hydrolysis, exonucleolytic-
GO:1900153IMP-positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay21278420
GO:2000036IMP-regulation of stem cell population maintenance22367759
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CNOT1GTF2A110921217643375 Affinity Capture-MS
CNOT1GTF2A111666017643375 Affinity Capture-MS
CNOT1CNOT211666010637334 Two-hybrid
CNOT1CNOT211091010637334 Two-hybrid
CNOT1CNOT411666010637334 Two-hybrid
CNOT1CNOT411091210637334 Two-hybrid
CNOT1BTG211666017353931 Affinity Capture-MS
CNOT1BTG211359317353931 Affinity Capture-MS
CNOT1CNOT811474410637334 17353931 Affinity Capture-MS; Two-hybrid
CNOT1CNOT811666010637334 17353931 Affinity Capture-MS; Two-hybrid
USP22CNOT111666019615732 Affinity Capture-MS
USP22CNOT111691419615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2442402
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040915-1'