AutismKB 2.0

Annotation Details for SETX


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Basic Information Top
Gene Symbol:SETX ( ALS4,AOA2,DKFZp781B151,FLJ12840,FLJ43459,KIAA0625,SCAR1,bA479K20.2 )
Gene Full Name: senataxin
Band: 9q34.13
Quick LinksEntrez ID:23064; OMIM: 608465; Uniprot ID:SETX_HUMAN; ENSEMBL ID: ENSG00000107290; HGNC ID: 445
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000228IDA-nuclear chromosome24105744
GO:0000781IEA-chromosome, telomeric region-
GO:0005634IDA-nucleus17562789
GO:0005654IDA-nucleoplasm17562789
GO:0005730IEA-nucleolus-
GO:0005737IDA-cytoplasm17562789
GO:0016604IDA-nuclear body-
GO:0030424IDA-axon21576111
GO:0030426IDA-growth cone21576111
GO:0045171IDA-intercellular bridge-
GO ID Evidence Qualifier GO_term References
GO:0001147IDA-transcription termination site sequence-specific DNA binding21700224
GO:0003677IC-DNA binding17562789
GO:0003678TAS-DNA helicase activity17562789
GO:0005515IPI-protein binding19515850
GO:0005524IEA-ATP binding-
GO:0042802IPI-identical protein binding24244371
GO ID Evidence Qualifier GO_term References
GO:0000165IDA-MAPK cascade21576111
GO:0006302IDA-double-strand break repair17562789
GO:0006310IEA-DNA recombination-
GO:0006353IMP-DNA-templated transcription, termination26700805
GO:0006369IEA-termination of RNA polymerase II transcription-
GO:0006376IMP-mRNA splice site selection19515850
GO:0006396TAS-RNA processing17562789
GO:0006974IDA-cellular response to DNA damage stimulus17562789
GO:0007283IEA-spermatogenesis-
GO:0007623IEA-circadian rhythm-
GO:0008543IDA-fibroblast growth factor receptor signaling pathway21576111
GO:0010976IDA-positive regulation of neuron projection development21576111
GO:0032508IEA-DNA duplex unwinding-
GO:0033120IMP-positive regulation of RNA splicing19515850
GO:0034599IDA-cellular response to oxidative stress17562789
GO:0043066IDA-negative regulation of apoptotic process21576111
GO:0043491IDA-protein kinase B signaling21576111
GO:0044344IDA-cellular response to fibroblast growth factor stimulus21576111
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter19515850
GO:0060566IMP-positive regulation of DNA-templated transcription, termination19515850
GO:0070301IDA-cellular response to hydrogen peroxide17562789
GO:0071300IDA-cellular response to retinoic acid21576111
GO:2000144IMP-positive regulation of DNA-templated transcription, initiation21700224
GO:2000806IMP-positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled21700224
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SETXUBE2I11669920936779 Two-hybrid
SETXUBE2I11317720936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2443480
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070402-1'