AutismKB 2.0

Annotation Details for HECW1


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Basic Information Top
Gene Symbol:HECW1 ( KIAA0322,NEDL1 )
Gene Full Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Band: 7p14.1-p13
Quick LinksEntrez ID:23072; OMIM: 610384; Uniprot ID:HECW1_HUMAN; ENSEMBL ID: ENSG00000002746; HGNC ID: 22195
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0061630TAS-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0016567IEA-protein ubiquitination-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HECW1DVL110818814684739 Affinity Capture-Western; Two-hybrid
HECW1DVL111670514684739 Affinity Capture-Western; Two-hybrid
HECW1SCNN1A11670511244092 Far Western
HECW1SCNN1A11224111244092 Far Western
HECW1SCNN1B11670511244092 Far Western
HECW1SCNN1B11224211244092 Far Western
HECW1SOD111253014684739 Affinity Capture-Western
HECW1SOD111670514684739 Affinity Capture-Western
HECW1SSR411670514684739 Affinity Capture-Western
HECW1SSR411262614684739 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2444115
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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