AutismKB 2.0

Annotation Details for FOXO1


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Basic Information Top
Gene Symbol:FOXO1 ( FKH1,FKHR,FOXO1A )
Gene Full Name: forkhead box O1
Band: 13q14.11
Quick LinksEntrez ID:2308; OMIM: 136533; Uniprot ID:FOXO1_HUMAN; ENSEMBL ID: ENSG00000150907; HGNC ID: 3819
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11311120
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11237865
GO:0005739ISS-mitochondrion22510882
GO:0005829ISS-cytosol22510882
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0000981IBA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0000989IEA-transcription factor activity, transcription factor binding-
GO:0001078IEA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001223IEA-transcription coactivator binding-
GO:0003682ISS-chromatin binding22510882
GO:0005515IPI-protein binding11237865
GO:0008013IDA-beta-catenin binding15905404
GO:0031625IPI-ubiquitin protein ligase binding20543840
GO:0043565IDA-sequence-specific DNA binding12228231
GO:0051721ISS-protein phosphatase 2A binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001568IEA-blood vessel development-
GO:0001659ISS-temperature homeostasis22510882
GO:0001678ISS-cellular glucose homeostasis22510882
GO:0006351IEA-transcription, DNA-templated-
GO:0006473ISS-protein acetylation22510882
GO:0006914IEA-autophagy-
GO:0006915IEA-apoptotic process-
GO:0006974ISS-cellular response to DNA damage stimulus-
GO:0008286ISS-insulin receptor signaling pathway-
GO:0009267IDA-cellular response to starvation20543840
GO:0009267ISS-cellular response to starvation22510882
GO:0010508IMP-positive regulation of autophagy20543840
GO:0031018TAS-endocrine pancreas development-
GO:0032869ISS-cellular response to insulin stimulus-
GO:0032873IDA-negative regulation of stress-activated MAPK cascade19696738
GO:0034599ISS-cellular response to oxidative stress-
GO:0035947IEA-regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter-
GO:0043065IMP-positive regulation of apoptotic process20543840
GO:0043066IDA-negative regulation of apoptotic process10871843
GO:0045444ISS-fat cell differentiation22510882
GO:0045599ISS-negative regulation of fat cell differentiation-
GO:0045722IEA-positive regulation of gluconeogenesis-
GO:0045732IMP-positive regulation of protein catabolic process20543840
GO:0045892ISS-negative regulation of transcription, DNA-templated22510882
GO:0045893IDA-positive regulation of transcription, DNA-templated7862145
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter10871843
GO:0070166IEA-enamel mineralization-
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0070417ISS-cellular response to cold22510882
GO:0071455IDA-cellular response to hyperoxia20543840
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:0071732ISS-cellular response to nitric oxide-
GO:0090090IEA-negative regulation of canonical Wnt signaling pathway-
GO:0097150IEA-neuronal stem cell population maintenance-
GO:1902617IEA-response to fluoride-
GO:2000177IEA-regulation of neural precursor cell proliferation-
GO:2000377IEA-regulation of reactive oxygen species metabolic process-
GO:2000505ISS-regulation of energy homeostasis22510882
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FOXO1PARP110665219281796 Affinity Capture-Western; Reconstituted Complex
FOXO1PARP110859719281796 Affinity Capture-Western; Reconstituted Complex
FOXO1AKT110671016076959 Biochemical Activity
FOXO1AKT110859716076959 Biochemical Activity
FOXO1AR10686212482965 Affinity Capture-Western; Far Western; Two-hybrid
FOXO1AR10859712482965 Affinity Capture-Western; Far Western; Two-hybrid
FOXO1CEBPB10748011893744 Reconstituted Complex
FOXO1CEBPB10859711893744 Reconstituted Complex
FOXO1CREBBP10777710973497 15220471 16154098 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
FOXO1CREBBP10859710973497 15220471 16154098 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
FOXO1ESR110859711435445 Reconstituted Complex; Two-hybrid
FOXO1ESR110840311435445 Reconstituted Complex; Two-hybrid
SRCFOXO111259210973497 Reconstituted Complex
SRCFOXO110859710973497 Reconstituted Complex
YWHAGFOXO111336411237865 Affinity Capture-Western
YWHAGFOXO110859711237865 Affinity Capture-Western
YWHAZFOXO110859711237865 Affinity Capture-Western
YWHAZFOXO111336611237865 Affinity Capture-Western
HOXA5FOXO110944212163409 Reconstituted Complex
HOXA5FOXO110859712163409 Reconstituted Complex
HNF4AFOXO110941412519792 19740748 Affinity Capture-Western; Reconstituted Complex
HNF4AFOXO110859712519792 19740748 Affinity Capture-Western; Reconstituted Complex
UBCFOXO111316413679577 15668399 Affinity Capture-Western; Reconstituted Complex
UBCFOXO110859713679577 15668399 Affinity Capture-Western; Reconstituted Complex
SMAD3FOXO111026315084259 Affinity Capture-Western
SMAD3FOXO110859715084259 Affinity Capture-Western
SMAD4FOXO111026415084259 Affinity Capture-Western
SMAD4FOXO110859715084259 Affinity Capture-Western
SIRT2FOXO110859715220471 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SIRT2FOXO111659315220471 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SKP2FOXO111239315668399 Affinity Capture-Western; Reconstituted Complex
SKP2FOXO110859715668399 Affinity Capture-Western; Reconstituted Complex
SIRT1FOXO111698316154098 Affinity Capture-Western
SIRT1FOXO110859716154098 Affinity Capture-Western
PMLFOXO111138416154098 Affinity Capture-Western
PMLFOXO110859716154098 Affinity Capture-Western
LRPPRCFOXO110859717050673 Reconstituted Complex
LRPPRCFOXO111543217050673 Reconstituted Complex
TSC2FOXO111310017077083 Affinity Capture-Western; Co-localization; Reconstituted Complex
TSC2FOXO110859717077083 Affinity Capture-Western; Co-localization; Reconstituted Complex
RFWD2FOXO112213618815134 Affinity Capture-Western
RFWD2FOXO110859718815134 Affinity Capture-Western
HOXA11FOXO110944719727442 Affinity Capture-Western
HOXA11FOXO110859719727442 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
FOXO1FHL221747915692560 FOXO1A interacts with FHL2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1890077
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061013-59'