AutismKB 2.0

Annotation Details for KDM4C


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Basic Information Top
Gene Symbol:KDM4C ( FLJ25949,GASC1,JHDM3C,JMJD2C,KIAA0780,bA146B14.1 )
Gene Full Name: lysine (K)-specific demethylase 4C
Band: 9p24.1
Quick LinksEntrez ID:23081; OMIM: 605469; Uniprot ID:KDM4C_HUMAN; ENSEMBL ID: ENSG00000107077; HGNC ID: 17071
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin17277772
GO:0005654TAS-nucleoplasm-
GO:0005721IEA-pericentric heterochromatin-
GO ID Evidence Qualifier GO_term References
GO:0003682IEA-chromatin binding-
GO:0008270IDA-zinc ion binding21914792
GO:0019899IPI-enzyme binding17277772
GO:0032452EXP-histone demethylase activity18066052
GO:0032452TAS-histone demethylase activity-
GO:0032454IDA-histone demethylase activity (H3-K9 specific)18066052
GO:0032454IMP-histone demethylase activity (H3-K9 specific)17277772
GO:0050681IPI-androgen receptor binding17277772
GO:0051864IDA-histone demethylase activity (H3-K36 specific)21914792
GO ID Evidence Qualifier GO_term References
GO:0001825IEA-blastocyst formation-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357IDA-regulation of transcription from RNA polymerase II promoter17277772
GO:0008284IMP-positive regulation of cell proliferation17277772
GO:0010628IEA-positive regulation of gene expression-
GO:0033169IDA-histone H3-K9 demethylation18066052
GO:0033169IMP-histone H3-K9 demethylation17277772
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0055114IEA-oxidation-reduction process-
GO:0070544IDA-histone H3-K36 demethylation21914792
GO:1900113IEA-negative regulation of histone H3-K9 trimethylation-
GO:2000036IEA-regulation of stem cell population maintenance-
GO:2000736IEA-regulation of stem cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KDM4CH3F3A10927217403666 Affinity Capture-MS
KDM4CH3F3A11671217403666 Affinity Capture-MS
KDM4CHIST1H3A11394616732293 Biochemical Activity
KDM4CHIST1H3A11671216732293 Biochemical Activity
KDM4CKDM4A11503517207460 Affinity Capture-Western
KDM4CKDM4A11671217207460 Affinity Capture-Western
KDM4CKDM4C11671217207460 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1924054
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018