Gene Symbol:	FOXO3 ( AF6q21,DKFZp781A0677,FKHRL1,FKHRL1P2,FOXO2,FOXO3A,MGC12739,MGC31925 )
Gene Full Name:	forkhead box O3
Band:	6q21
Quick Links	Entrez ID:2309; OMIM: 602681; Uniprot ID:FOXO3_HUMAN; ENSEMBL ID: ENSG00000118689; HGNC ID: 3821
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	10102273
GO:0005654	IDA	-	nucleoplasm	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	10102273
GO:0005739	IEA	-	mitochondrion	-
GO:0005829	IDA	-	cytosol	23640897
GO:0005829	TAS	-	cytosol	-
GO:0016020	IEA	-	membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001047	ISS	-	core promoter binding	-
GO:0001221	IEA	-	transcription cofactor binding	-
GO:0001227	IDA	-	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	20371612
GO:0001228	IEA	-	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	-
GO:0003677	IDA	-	DNA binding	21329882
GO:0003700	IDA	-	transcription factor activity, sequence-specific DNA binding	14734530
GO:0005515	IPI	-	protein binding	14976264
GO:0008013	IPI	-	beta-catenin binding	15905404
GO:0019901	IPI	-	protein kinase binding	16751106
GO:0031490	ISS	-	chromatin DNA binding	-
GO:0043565	IDA	-	sequence-specific DNA binding	10102273

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IDA	-	negative regulation of transcription from RNA polymerase II promoter	20371612
GO:0000122	IMP	-	negative regulation of transcription from RNA polymerase II promoter	18787191
GO:0001542	IEA	-	ovulation from ovarian follicle	-
GO:0001544	IEA	-	initiation of primordial ovarian follicle growth	-
GO:0001547	IEA	-	antral ovarian follicle growth	-
GO:0001556	IEA	-	oocyte maturation	-
GO:0006357	ISS	-	regulation of transcription from RNA polymerase II promoter	-
GO:0006366	IEA	-	transcription from RNA polymerase II promoter	-
GO:0006417	IDA	-	regulation of translation	21329882
GO:0007568	IEA	-	aging	-
GO:0030330	IEA	-	DNA damage response, signal transduction by p53 class mediator	-
GO:0031667	IEA	-	response to nutrient levels	-
GO:0033209	IMP	-	tumor necrosis factor-mediated signaling pathway	15084260
GO:0034599	ISS	-	cellular response to oxidative stress	-
GO:0042493	IEA	-	response to drug	-
GO:0043065	IDA	-	positive regulation of apoptotic process	20371612
GO:0043525	IMP	-	positive regulation of neuron apoptotic process	10102273
GO:0045648	IDA	-	positive regulation of erythrocyte differentiation	14734530
GO:0045665	IEA	-	negative regulation of neuron differentiation	-
GO:0045893	IDA	-	positive regulation of transcription, DNA-templated	10102273
GO:0045944	IDA	-	positive regulation of transcription from RNA polymerase II promoter	10102273
GO:0048854	IEA	-	brain morphogenesis	-
GO:0071333	IEA	-	cellular response to glucose stimulus	-
GO:0071386	IEA	-	cellular response to corticosterone stimulus	-
GO:0071456	IEA	-	cellular response to hypoxia	-
GO:0071548	IEA	-	response to dexamethasone	-
GO:0090090	IEA	-	negative regulation of canonical Wnt signaling pathway	-
GO:0097150	IEA	-	neuronal stem cell population maintenance	-
GO:0097192	IEA	-	extrinsic apoptotic signaling pathway in absence of ligand	-
GO:1901300	IEA	-	positive regulation of hydrogen peroxide-mediated programmed cell death	-
GO:1903428	IEA	-	positive regulation of reactive oxygen species biosynthetic process	-
GO:1904646	IEA	-	cellular response to amyloid-beta	-
GO:1990090	IEA	-	cellular response to nerve growth factor stimulus	-
GO:1990785	IEA	-	response to water-immersion restraint stress	-
GO:2000177	IEA	-	regulation of neural precursor cell proliferation	-
GO:2000353	IEA	-	positive regulation of endothelial cell apoptotic process	-

Gene Symbol	Interactant	Interaction ID	References	Description
FOXO3	ATM	108598	18344987	Affinity Capture-Western; Reconstituted Complex
FOXO3	ATM	106962	18344987	Affinity Capture-Western; Reconstituted Complex
FOXO3	BRCA1	107140	18344987	Affinity Capture-Western
FOXO3	BRCA1	108598	18344987	Affinity Capture-Western
FOXO3	CREBBP	107777	15126506	Affinity Capture-Western
FOXO3	CREBBP	108598	15126506	Affinity Capture-Western
FOXO3	CTNNB1	107880	15905404	Affinity Capture-Western
FOXO3	CTNNB1	108598	15905404	Affinity Capture-Western
FOXO3	FANCD2	108598	20040763	Affinity Capture-Western
FOXO3	FANCD2	108474	20040763	Affinity Capture-Western
FOXO3	FKBP4	108598	20562859	Affinity Capture-MS
FOXO3	FKBP4	108578	20562859	Affinity Capture-MS
YWHAZ	FOXO3	108598	10102273	Affinity Capture-Western
YWHAZ	FOXO3	113366	10102273	Affinity Capture-Western
SMAD3	FOXO3	110263	15084259	Affinity Capture-Western
SMAD3	FOXO3	108598	15084259	Affinity Capture-Western
SMAD4	FOXO3	108598	15084259	Affinity Capture-Western
SMAD4	FOXO3	110264	15084259	Affinity Capture-Western
SIRT1	FOXO3	116983	15126506	Affinity Capture-Western
SIRT1	FOXO3	108598	15126506	Affinity Capture-Western
USP7	FOXO3	108598	16964248	Affinity Capture-Western
USP7	FOXO3	113622	16964248	Affinity Capture-Western
H2AFX	FOXO3	109268	18344987	Affinity Capture-Western
H2AFX	FOXO3	108598	18344987	Affinity Capture-Western
RAD17	FOXO3	111821	18344987	Affinity Capture-Western
RAD17	FOXO3	108598	18344987	Affinity Capture-Western
MYC	FOXO3	110694	18393360	Affinity Capture-Western
MYC	FOXO3	108598	18393360	Affinity Capture-Western
SIRT3	FOXO3	116982	18781224	Affinity Capture-Western
SIRT3	FOXO3	108598	18781224	Affinity Capture-Western
GBAS	FOXO3	108598	20562859	Affinity Capture-MS
GBAS	FOXO3	108901	20562859	Affinity Capture-MS
PGK1	FOXO3	111251	20562859	Affinity Capture-MS
PGK1	FOXO3	108598	20562859	Affinity Capture-MS
C12orf44	FOXO3	121948	20562859	Affinity Capture-MS
C12orf44	FOXO3	108598	20562859	Affinity Capture-MS
YWHAB	FOXO3	113361	20562859	Affinity Capture-MS
YWHAB	FOXO3	108598	20562859	Affinity Capture-MS
YWHAE	FOXO3	113363	20562859	Affinity Capture-MS
YWHAE	FOXO3	108598	20562859	Affinity Capture-MS
YWHAH	FOXO3	108598	20562859	Affinity Capture-MS
YWHAH	FOXO3	113365	20562859	Affinity Capture-MS

AutismKB 2.0

Annotation Details for FOXO3