AutismKB 2.0

Annotation Details for PHF8


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Basic Information Top
Gene Symbol:PHF8 ( DKFZp686E0868,JHDM1F,KIAA1111,MRXSSD,ZNF422 )
Gene Full Name: PHD finger protein 8
Band: Xp11.22
Quick LinksEntrez ID:23133; OMIM: 300560; Uniprot ID:PHF8_HUMAN; ENSEMBL ID: ENSG00000172943; HGNC ID: 20672
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IC-nucleus20023638
GO:0005634IDA-nucleus19843542
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus20208542
GO:0031965IDA-nuclear membrane-
GO ID Evidence Qualifier GO_term References
GO:0003682IDA-chromatin binding20622854
GO:0005506IDA-iron ion binding20023638
GO:0005515IPI-protein binding20208542
GO:0008270IDA-zinc ion binding20023638
GO:0016706IDA-oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors20023638
GO:0032452IDA-histone demethylase activity19843542
GO:0032452TAS-histone demethylase activity-
GO:0032454IDA-histone demethylase activity (H3-K9 specific)20023638
GO:0035064IDA-methylated histone binding20023638
GO:0035575IDA-histone demethylase activity (H4-K20 specific)20622853
GO:0051864IDA-histone demethylase activity (H3-K36 specific)20208542
GO:0071558IDA-histone demethylase activity (H3-K27 specific)20622853
GO ID Evidence Qualifier GO_term References
GO:0000082IMP-G1/S transition of mitotic cell cycle20622854
GO:0006351IEA-transcription, DNA-templated-
GO:0007420ISS-brain development-
GO:0033169IDA-histone H3-K9 demethylation20023638
GO:0035574IDA-histone H4-K20 demethylation20622853
GO:0045893IDA-positive regulation of transcription, DNA-templated20622853
GO:0045893IMP-positive regulation of transcription, DNA-templated20346720
GO:0045943IDA-positive regulation of transcription from RNA polymerase I promoter20208542
GO:0055114IEA-oxidation-reduction process-
GO:0061188IDA-negative regulation of chromatin silencing at rDNA20208542
GO:0070544IDA-histone H3-K36 demethylation20208542
GO:0071557IDA-histone H3-K27 demethylation20622853
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PHF8SUMO211249719394292 Affinity Capture-MS
PHF8SUMO211675119394292 Affinity Capture-MS
PHF8HIST1H3A11394620208542 Biochemical Activity; Reconstituted Complex
PHF8HIST1H3A11675120208542 Biochemical Activity; Reconstituted Complex
PHF8ASH2L11675120208542 Affinity Capture-Western
PHF8ASH2L11452820208542 Affinity Capture-Western
PHF8WDR511675120208542 Affinity Capture-Western; Co-localization
PHF8WDR511627220208542 Affinity Capture-Western; Co-localization
RPAP1PHF811675117643375 Affinity Capture-MS
RPAP1PHF811748717643375 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2444341
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060419-1'