AutismKB 2.0

Annotation Details for FLNA


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Basic Information Top
Gene Symbol:FLNA ( ABP-280,ABPX,DKFZp434P031,FLN,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2 )
Gene Full Name: filamin A, alpha
Band: Xq28
Quick LinksEntrez ID:2316; OMIM: 300017; Uniprot ID:FLNA_HUMAN; ENSEMBL ID: ENSG00000196924; HGNC ID: 3754
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus15684392
GO:0005730IMP-nucleolus22307607
GO:0005737IDA-cytoplasm15684392
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane18322202
GO:0005911IDA-cell-cell junction16291724
GO:0005925IDA-focal adhesion21423176
GO:0015629IC-actin cytoskeleton2391361
GO:0015629IDA-actin cytoskeleton-
GO:0016020IDA-membrane19946888
GO:0030018ISS-Z disc24951510
GO:0030863IEA-cortical cytoskeleton-
GO:0031012IDA-extracellular matrix23979707
GO:0031523IDA-Myb complex18548008
GO:0031941IDAcolocalizes_withfilamentous actin25358863
GO:0043025IEA-neuronal cell body-
GO:0043198IEA-dendritic shaft-
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO:0097440IEA-apical dendrite-
GO ID Evidence Qualifier GO_term References
GO:0001664IPI-G-protein coupled receptor binding26460884
GO:0001948IDA-glycoprotein binding1833070
GO:0003723IDA-RNA binding22658674
GO:0004871IMP-signal transducer activity12761501
GO:0005515IPI-protein binding4044584
GO:0008134IPI-transcription factor binding15684392
GO:0015459IDA-potassium channel regulator activity24951510
GO:0017048IDA-Rho GTPase binding10051605
GO:0017160IDA-Ral GTPase binding10051605
GO:0019900IPI-kinase binding20713593
GO:0031267IDA-small GTPase binding10051605
GO:0031852IEA-mu-type opioid receptor binding-
GO:0034988IDA-Fc-gamma receptor I complex binding1833070
GO:0042803IDA-protein homodimerization activity2391361
GO:0044325IPI-ion channel binding24951510
GO:0045296IDA-cadherin binding25468996
GO:0046332IEA-SMAD binding-
GO:0048365IDA-Rac GTPase binding10051605
GO:0051015IDA-actin filament binding2391361
GO:0051020IPI-GTPase binding16291724
GO ID Evidence Qualifier GO_term References
GO:0002576TAS-platelet degranulation-
GO:0007195IMP-adenylate cyclase-inhibiting dopamine receptor signaling pathway10692483
GO:0016479IDA-negative regulation of transcription from RNA polymerase I promoter22307607
GO:0021943IEA-formation of radial glial scaffolds-
GO:0021987IEA-cerebral cortex development-
GO:0030168TAS-platelet activation-
GO:0030334IDA-regulation of cell migration16291724
GO:0031532IDA-actin cytoskeleton reorganization10051605
GO:0034329TAS-cell junction assembly-
GO:0034394IDA-protein localization to cell surface18322202
GO:0042177IMP-negative regulation of protein catabolic process18322202
GO:0042789IEA-mRNA transcription from RNA polymerase II promoter-
GO:0042993IMP-positive regulation of transcription factor import into nucleus15684392
GO:0043066IMP-negative regulation of apoptotic process18177638
GO:0043113IDA-receptor clustering10692483
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043433IDA-negative regulation of sequence-specific DNA binding transcription factor activity15684392
GO:0044319IDA-wound healing, spreading of cells16291724
GO:0045184IDA-establishment of protein localization18322202
GO:0050821IMP-protein stabilization18322202
GO:0051220IMP-cytoplasmic sequestering of protein17536008
GO:0051764IDA-actin crosslink formation10051605
GO:0060271IMP-cilium assembly22121117
GO:0070527IMP-platelet aggregation23382103
GO:0071526IGI-semaphorin-plexin signaling pathway25358863
GO:0072659IDA-protein localization to plasma membrane24951510
GO:0090307IDA-mitotic spindle assembly18548008
GO:1900026IMP-positive regulation of substrate adhesion-dependent cell spreading18177638
GO:1901381IDA-positive regulation of potassium ion transmembrane transport24951510
GO:1905000IC-regulation of membrane repolarization during atrial cardiac muscle cell action potential-
GO:1905031ISS-regulation of membrane repolarization during cardiac muscle cell action potential24951510
GO:2000179IEA-positive regulation of neural precursor cell proliferation-
GO:2001046IMP-positive regulation of integrin-mediated signaling pathway18177638
GO:2001224IEA-positive regulation of neuron migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FLNAAPC10682120936779 Two-hybrid
FLNAAPC10860520936779 Two-hybrid
FLNAAR10686212682292 Two-hybrid
FLNAAR10860512682292 Two-hybrid
FLNABRCA210714211602572 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FLNABRCA210860511602572 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FLNACASR10860511390379 11390380 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FLNACASR10729611390379 11390380 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FLNAMAPK1410860520936779 Two-hybrid
FLNAMAPK1410781920936779 Two-hybrid
FLNADCN10860512106908 Reconstituted Complex
FLNADCN10800212106908 Reconstituted Complex
FLNADMWD10810219615732 Affinity Capture-MS
FLNADMWD10860519615732 Affinity Capture-MS
FLNADRD210860512181426 Affinity Capture-Western
FLNADRD210814712181426 Affinity Capture-Western
FLNADRD310860511911837 Two-hybrid
FLNADRD310814811911837 Two-hybrid
FLNAF31086059490735 Reconstituted Complex
FLNAF31084519490735 Reconstituted Complex
VHLFLNA1132698674032 12169691 Two-hybrid
VHLFLNA1086058674032 12169691 Two-hybrid
ITGB1FLNA1086059722563 11807098 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITGB1FLNA1098949722563 11807098 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RALAFLNA10860510051605 Affinity Capture-Western; Reconstituted Complex
RALAFLNA11183410051605 Affinity Capture-Western; Reconstituted Complex
TRAF2FLNA10860510617615 Affinity Capture-Western
TRAF2FLNA11303810617615 Affinity Capture-Western
MYOTFLNA11487811038172 Affinity Capture-Western
MYOTFLNA10860511038172 Affinity Capture-Western
TRIOFLNA11305511146652 Reconstituted Complex; Two-hybrid
TRIOFLNA10860511146652 Reconstituted Complex; Two-hybrid
SH2B3FLNA10860511163396 Affinity Capture-Western; Two-hybrid
SH2B3FLNA11533611163396 Affinity Capture-Western; Two-hybrid
GP1BAFLNA10907311700320 Affinity Capture-Western
GP1BAFLNA10860511700320 Affinity Capture-Western
ITGB7FLNA10990111781567 Reconstituted Complex
ITGB7FLNA10860511781567 Reconstituted Complex
ITGB3FLNA10860511807098 Two-hybrid
ITGB3FLNA10989611807098 Two-hybrid
ITGB6FLNA10990011807098 Two-hybrid
ITGB6FLNA10860511807098 Two-hybrid
NPHP1FLNA11092712006559 Affinity Capture-Western; Two-hybrid
NPHP1FLNA10860512006559 Affinity Capture-Western; Two-hybrid
FILIP1FLNA11802912055638 Affinity Capture-Western; Two-hybrid
FILIP1FLNA10860512055638 Affinity Capture-Western; Two-hybrid
FLNBFLNA10860512393796 Affinity Capture-Western; Two-hybrid
FLNBFLNA10860612393796 Affinity Capture-Western; Two-hybrid
FBLIM1FLNA12012812679033 Affinity Capture-Western; Two-hybrid
FBLIM1FLNA10860512679033 Affinity Capture-Western; Two-hybrid
CMIPFLNA12331315128042 Affinity Capture-Western; Two-hybrid
CMIPFLNA10860515128042 Affinity Capture-Western; Two-hybrid
G3BP1FLNA11544819615732 Affinity Capture-MS
G3BP1FLNA10860519615732 Affinity Capture-MS
OTUD1FLNA12863819615732 Affinity Capture-MS
OTUD1FLNA10860519615732 Affinity Capture-MS
OTUD5FLNA12073819615732 Affinity Capture-MS
OTUD5FLNA10860519615732 Affinity Capture-MS
USP45FLNA12443019615732 Affinity Capture-MS
USP45FLNA10860519615732 Affinity Capture-MS
BANF1FLNA11434219759913 Affinity Capture-MS
BANF1FLNA10860519759913 Affinity Capture-MS
CAMKK2FLNA11588920562859 Affinity Capture-MS
CAMKK2FLNA10860520562859 Affinity Capture-MS
SRCFLNA11259220936779 Two-hybrid
SRCFLNA10860520936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95556
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2145'