AutismKB 2.0

Annotation Details for CYFIP1


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Basic Information Top
Gene Symbol:CYFIP1 ( FLJ45151,P140SRA-1,SHYC,SRA1 )
Gene Full Name: cytoplasmic FMR1 interacting protein 1
Band: 15q11.2
Quick LinksEntrez ID:23191; OMIM: 606322; Uniprot ID:CYFP1_HUMAN; ENSEMBL ID: ENSG00000068793; HGNC ID: 13759
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726ISS-ruffle-
GO:0005576TAS-extracellular region-
GO:0005829TAS-cytosol-
GO:0005845ISS-mRNA cap binding complex-
GO:0005925IDA-focal adhesion21423176
GO:0030027ISS-lamellipodium-
GO:0031209IMP-SCAR complex21107423
GO:0032433IEA-filopodium tip-
GO:0034774TAS-secretory granule lumen-
GO:0035580TAS-specific granule lumen-
GO:0043005ISS-neuron projection-
GO:0043025IEA-neuronal cell body-
GO:0043195IEA-terminal bouton-
GO:0043197IEA-dendritic spine-
GO:0044294IEA-dendritic growth cone-
GO:0044295IEA-axonal growth cone-
GO:0048471ISS-perinuclear region of cytoplasm-
GO:0060076IEA-excitatory synapse-
GO:0070062IDA-extracellular exosome20458337
GO:0090724IEA-central region of growth cone-
GO:0090725IEA-peripheral region of growth cone-
GO:1904724TAS-tertiary granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0000340IEA-RNA 7-methylguanosine cap binding-
GO:0005515IPI-protein binding11438699
GO:0032403IDA-protein complex binding18560548
GO:0032403IMP-protein complex binding21107423
GO:0048365IMPcontributes_toRac GTPase binding21107423
GO:0048365ISS-Rac GTPase binding-
GO:0051015ISS-actin filament binding-
GO ID Evidence Qualifier GO_term References
GO:0006417IEA-regulation of translation-
GO:0008360IEA-regulation of cell shape-
GO:0016601IMP-Rac protein signal transduction21107423
GO:0030032ISS-lamellipodium assembly-
GO:0031529ISS-ruffle organization-
GO:0032869IEA-cellular response to insulin stimulus-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0043312TAS-neutrophil degranulation-
GO:0045773IEA-positive regulation of axon extension-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048675IMP-axon extension16260607
GO:0050890IMP-cognition17519220
GO:0051388IEA-positive regulation of neurotrophin TRK receptor signaling pathway-
GO:0051602IEA-response to electrical stimulus-
GO:0097484IEA-dendrite extension-
GO:0099563IEA-modification of synaptic structure-
GO:1900006IEA-positive regulation of dendrite development-
GO:1900029IEA-positive regulation of ruffle assembly-
GO:1903422IEA-negative regulation of synaptic vesicle recycling-
GO:2000601IMP-positive regulation of Arp2/3 complex-mediated actin nucleation21107423
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CYFIP1APBB111680016055720 Affinity Capture-MS
CYFIP1APBB110681916055720 Affinity Capture-MS
CYFIP1FMR111680011438699 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CYFIP1FMR110861911438699 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CYFIP1NCL11680011438699 Affinity Capture-Western
CYFIP1NCL11077111438699 Affinity Capture-Western
CYFIP1FXR111376011438699 Affinity Capture-Western
CYFIP1FXR111680011438699 Affinity Capture-Western
CYFIP1GAS711409416055720 Affinity Capture-MS
CYFIP1GAS711680016055720 Affinity Capture-MS
CYFIP1FXR211489011438699 Affinity Capture-Western; Two-hybrid
CYFIP1FXR211680011438699 Affinity Capture-Western; Two-hybrid
CYFIP1TCERG111612016055720 Affinity Capture-MS
CYFIP1TCERG111680016055720 Affinity Capture-MS
PRPF40ACYFIP111680016055720 Affinity Capture-MS
PRPF40ACYFIP112079216055720 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338801
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8557'