AutismKB 2.0

Annotation Details for FLT1


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Basic Information Top
Gene Symbol:FLT1 ( FLT,VEGFR1 )
Gene Full Name: fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Band: 13q12.3
Quick LinksEntrez ID:2321; OMIM: 165070; Uniprot ID:VGFR1_HUMAN; ENSEMBL ID: ENSG00000102755; HGNC ID: 3763
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615TAS-extracellular space8248162
GO:0005768IEA-endosome-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane11513746
GO:0005925IDA-focal adhesion21423176
GO:0015629IDA-actin cytoskeleton-
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004714TAS-transmembrane receptor protein tyrosine kinase activity8248162
GO:0005021IDA-vascular endothelial growth factor-activated receptor activity1312256
GO:0005021IMP-vascular endothelial growth factor-activated receptor activity11312102
GO:0005515IPI-protein binding1312256
GO:0005524IEA-ATP binding-
GO:0019838IPI-growth factor binding1312256
GO:0036326IDA-VEGF-A-activated receptor activity8605350
GO:0036327IDA-VEGF-B-activated receptor activity15952180
GO:0036332IDA-placental growth factor-activated receptor activity12796773
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0002548IDA-monocyte chemotaxis8605350
GO:0007169TAS-transmembrane receptor protein tyrosine kinase signaling pathway2158038
GO:0008284TAS-positive regulation of cell proliferation10748050
GO:0010863IMP-positive regulation of phospholipase C activity11312102
GO:0014068IMP-positive regulation of phosphatidylinositol 3-kinase signaling14633857
GO:0016477IMP-cell migration8605350
GO:0018108IDA-peptidyl-tyrosine phosphorylation9299537
GO:0030154IEA-cell differentiation-
GO:0030335IDA-positive regulation of cell migration8605350
GO:0030949IDA-positive regulation of vascular endothelial growth factor receptor signaling pathway1312256
GO:0035924IDA-cellular response to vascular endothelial growth factor stimulus8605350
GO:0036323IDA-vascular endothelial growth factor receptor-1 signaling pathway15952180
GO:0038084IEA-vascular endothelial growth factor signaling pathway-
GO:0043406IDA-positive regulation of MAP kinase activity9299537
GO:0043410IDA-positive regulation of MAPK cascade9299537
GO:0043552IMP-positive regulation of phosphatidylinositol 3-kinase activity11312102
GO:0045766IMP-positive regulation of angiogenesis14633857
GO:0046777IDA-protein autophosphorylation9299537
GO:0048010IDA-vascular endothelial growth factor receptor signaling pathway9299537
GO:0048010IMP-vascular endothelial growth factor receptor signaling pathway11312102
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048514ISS-blood vessel morphogenesis-
GO:0048598ISS-embryonic morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLCG1FLT11113519398617 Reconstituted Complex; Two-hybrid
PLCG1FLT11086099398617 Reconstituted Complex; Two-hybrid
PGFFLT11112499452434 Reconstituted Complex
PGFFLT11086099452434 Reconstituted Complex
VEGFBFLT11132669751730 10409677 Affinity Capture-Western; Reconstituted Complex
VEGFBFLT11086099751730 10409677 Affinity Capture-Western; Reconstituted Complex
SHC2FLT111730210749680 Two-hybrid
SHC2FLT110860910749680 Two-hybrid
SHC1FLT110860910749680 Two-hybrid
SHC1FLT111236110749680 Two-hybrid
KDRFLT110999212796773 Biochemical Activity
KDRFLT110860912796773 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95558
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050407-1'