Gene Symbol:	PLCB1 ( FLJ45792,PI-PLC,PLC-154,PLC-I,PLC154 )
Gene Full Name:	phospholipase C, beta 1 (phosphoinositide-specific)
Band:	20p12.3
Quick Links	Entrez ID:23236; OMIM: 607120; Uniprot ID:PLCB1_HUMAN; ENSEMBL ID: ENSG00000182621; HGNC ID: 15917
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000790	ISS	-	nuclear chromatin	-
GO:0005634	NAS	-	nucleus	10760467
GO:0005737	IDA	-	cytoplasm	11118617
GO:0005829	TAS	-	cytosol	-
GO:0016607	IDA	-	nuclear speck	12799190
GO:0031965	IEA	-	nuclear membrane	-
GO:0043209	IEA	-	myelin sheath	-
GO:0070062	IDA	-	extracellular exosome	19199708

GO ID	Evidence	Qualifier	GO_term	References
GO:0004435	ISS	-	phosphatidylinositol phospholipase C activity	-
GO:0004435	NAS	-	phosphatidylinositol phospholipase C activity	11118617
GO:0004435	TAS	-	phosphatidylinositol phospholipase C activity	-
GO:0004871	IEA	-	signal transducer activity	-
GO:0005096	IDA	-	GTPase activator activity	1322796
GO:0005509	IEA	-	calcium ion binding	-
GO:0005515	IPI	-	protein binding	25416956
GO:0005521	IEA	-	lamin binding	-
GO:0005546	IDA	-	phosphatidylinositol-4,5-bisphosphate binding	12799190
GO:0019899	IPI	-	enzyme binding	12799190
GO:0042803	ISS	-	protein homodimerization activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000086	ISS	-	G2/M transition of mitotic cell cycle	-
GO:0007165	NAS	-	signal transduction	11118617
GO:0007213	ISS	-	G-protein coupled acetylcholine receptor signaling pathway	-
GO:0007215	ISS	-	glutamate receptor signaling pathway	-
GO:0007223	TAS	-	Wnt signaling pathway, calcium modulating pathway	-
GO:0007613	ISS	-	memory	-
GO:0008277	ISS	-	regulation of G-protein coupled receptor protein signaling pathway	-
GO:0016042	IEA	-	lipid catabolic process	-
GO:0021987	ISS	-	cerebral cortex development	-
GO:0032735	ISS	-	positive regulation of interleukin-12 production	-
GO:0035556	IEA	-	intracellular signal transduction	-
GO:0035722	IDA	-	interleukin-12-mediated signaling pathway	11743656
GO:0035723	IDA	-	interleukin-15-mediated signaling pathway	11743656
GO:0040019	ISS	-	positive regulation of embryonic development	-
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0043647	TAS	-	inositol phosphate metabolic process	-
GO:0045444	IEA	-	fat cell differentiation	-
GO:0045663	ISS	-	positive regulation of myoblast differentiation	-
GO:0045892	ISS	-	negative regulation of transcription, DNA-templated	-
GO:0045893	ISS	-	positive regulation of transcription, DNA-templated	-
GO:0046330	IDA	-	positive regulation of JNK cascade	9500449
GO:0046488	ISS	-	phosphatidylinositol metabolic process	-
GO:0048009	ISS	-	insulin-like growth factor receptor signaling pathway	-
GO:0048639	ISS	-	positive regulation of developmental growth	-
GO:0060466	ISS	-	activation of meiosis involved in egg activation	-
GO:0070498	IDA	-	interleukin-1-mediated signaling pathway	8872139
GO:0080154	ISS	-	regulation of fertilization	-
GO:1900087	ISS	-	positive regulation of G1/S transition of mitotic cell cycle	-
GO:2000344	ISS	-	positive regulation of acrosome reaction	-
GO:2000438	ISS	-	negative regulation of monocyte extravasation	-
GO:2000560	ISS	-	positive regulation of CD24 biosynthetic process	-

Gene Symbol	Interactant	Interaction ID	References	Description
PLCB1	GNAQ	109038	12193606	Affinity Capture-Western
PLCB1	GNAQ	116841	12193606	Affinity Capture-Western
PLCB1	SPTBN1	116841	20936779	Two-hybrid
PLCB1	SPTBN1	112589	20936779	Two-hybrid
PLCB1	SLC9A3R1	114769	10980202	Affinity Capture-Western
PLCB1	SLC9A3R1	116841	10980202	Affinity Capture-Western
TRPM7	PLCB1	120177	11941371	Reconstituted Complex; Two-hybrid
TRPM7	PLCB1	116841	11941371	Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for PLCB1