AutismKB 2.0

Annotation Details for ARC


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Basic Information Top
Gene Symbol:ARC ( Arg3.1,KIAA0278 )
Gene Full Name: activity-regulated cytoskeleton-associated protein
Band: 8q24.3
Quick LinksEntrez ID:23237; OMIM: 612461; Uniprot ID:ARC_HUMAN; ENSEMBL ID: ENSG00000198576; HGNC ID: 648
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001669IEA-acrosomal vesicle-
GO:0005737IDA-cytoplasm21834987
GO:0005768IEA-endosome-
GO:0005886IDA-plasma membrane21834987
GO:0014069IEA-postsynaptic density-
GO:0015629IEA-actin cytoskeleton-
GO:0030054IEA-cell junction-
GO:0043197IEA-dendritic spine-
GO:0045211IEA-postsynaptic membrane-
No data
GO ID Evidence Qualifier GO_term References
GO:0006897IEA-endocytosis-
GO:0007010IMP-cytoskeleton organization21834987
GO:0007492IEA-endoderm development-
GO:0007612IEA-learning-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0016477IMP-cell migration21834987
GO:0022604IMP-regulation of cell morphogenesis21834987
GO:0048168IEA-regulation of neuronal synaptic plasticity-
GO:1900271IEA-regulation of long-term synaptic potentiation-
GO:2000969IEA-positive regulation of AMPA receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARCKRT1511684216189514 Two-hybrid
ARCKRT1511006416189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88067
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018