AutismKB 2.0

Annotation Details for WWC1


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Basic Information Top
Gene Symbol:WWC1 ( FLJ10865,FLJ23369,HBEBP3,HBEBP36,KIAA0869,KIBRA )
Gene Full Name: WW and C2 domain containing 1
Band: 5q34
Quick LinksEntrez ID:23286; OMIM: 610533; Uniprot ID:KIBRA_HUMAN; ENSEMBL ID: ENSG00000113645; HGNC ID: 29435
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16684779
GO:0005737IDA-cytoplasm16684779
GO:0005829IDA-cytosol24682284
GO:0005829TAS-cytosol-
GO:0032587IDA-ruffle membrane18190796
GO:0043234IEA-protein complex-
GO:0048471IDA-perinuclear region of cytoplasm18596123
GO ID Evidence Qualifier GO_term References
GO:0003713IDA-transcription coactivator activity16684779
GO:0005515IPI-protein binding16684779
GO:0019900IPI-kinase binding24682284
GO:0030674IEA-protein binding, bridging-
GO:0032947IDA-protein complex scaffold24682284
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter24682284
GO:0006351IEA-transcription, DNA-templated-
GO:0016477IDA-cell migration18596123
GO:0030010TAS-establishment of cell polarity24682284
GO:0032386TAS-regulation of intracellular transport24682284
GO:0035329TAS-hippo signaling-
GO:0035330IMP-regulation of hippo signaling20159598
GO:0035331IDA-negative regulation of hippo signaling24682284
GO:0043410IDA-positive regulation of MAPK cascade18190796
GO:0046621IMP-negative regulation of organ growth24682284
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WWC1PRKCZ11157615081397 Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
WWC1PRKCZ11688415081397 Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
WWC1HIST1H3A11394616684779 Far Western; Reconstituted Complex
WWC1HIST1H3A11688416684779 Far Western; Reconstituted Complex
WWC1FEZ211499616484223 Two-hybrid
WWC1FEZ211688416484223 Two-hybrid
WWC1FEZ111499716484223 Reconstituted Complex; Two-hybrid
WWC1FEZ111688416484223 Reconstituted Complex; Two-hybrid
WWC1DLC111566716684779 Affinity Capture-Western; Reconstituted Complex
WWC1DLC111688416684779 Affinity Capture-Western; Reconstituted Complex
C1orf103WWC112090516169070 Two-hybrid
C1orf103WWC111688416169070 Two-hybrid
CDC73WWC112272416169070 Two-hybrid
CDC73WWC111688416169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
WWC1rs17070145 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
WWC1rs17070145 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:2388637
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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