AutismKB 2.0

Annotation Details for SMG6


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Basic Information Top
Gene Symbol:SMG6 ( C17orf31,EST1A,KIAA0732,SMG-6 )
Gene Full Name: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Band: 17p13.3
Quick LinksEntrez ID:23293; OMIM: 610963; Uniprot ID:EST1A_HUMAN; ENSEMBL ID: ENSG00000070366; HGNC ID: 17809
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000333IDAcolocalizes_withtelomerase catalytic core complex12676087
GO:0000781IEA-chromosome, telomeric region-
GO:0005634IDA-nucleus14636577
GO:0005697TAS-telomerase holoenzyme complex12699629
GO:0005730IDA-nucleolus12676087
GO:0005737IDA-cytoplasm14636577
GO:0005829IDA-cytosol19060897
GO:0005829TAS-cytosol-
GO:0035145IDAcolocalizes_withexon-exon junction complex20930030
GO ID Evidence Qualifier GO_term References
GO:0004521IDA-endoribonuclease activity19060897
GO:0004521IMP-endoribonuclease activity18974281
GO:0004521TAS-endoribonuclease activity-
GO:0005515IPI-protein binding12699629
GO:0042162IDA-telomeric DNA binding12699629
GO:0043021IPI-ribonucleoprotein complex binding12676087
GO:0046872IEA-metal ion binding-
GO:0070034IPI-telomerase RNA binding17940095
GO:0070182IPI-DNA polymerase binding15857955
GO ID Evidence Qualifier GO_term References
GO:0000184IMP-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay18974281
GO:0000184TAS-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay16488880
GO:0006406TAS-mRNA export from nucleus16488880
GO:0032204IMP-regulation of telomere maintenance12699629
GO:0032210IC-regulation of telomere maintenance via telomerase22011238
GO:0032210TAS-regulation of telomere maintenance via telomerase16507993
GO:0035303TAS-regulation of dephosphorylation15721257
GO:0043487IBA-regulation of RNA stability-
GO:0051972IC-regulation of telomerase activity22011238
GO:0090502IEA-RNA phosphodiester bond hydrolysis, endonucleolytic-
GO:1904354IDA-negative regulation of telomere capping12676087
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SMG6TERT11688812699629 Reconstituted Complex
SMG6TERT11287412699629 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2144117
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081107-52'