AutismKB 2.0

Annotation Details for NEDD4L


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Basic Information Top
Gene Symbol:NEDD4L ( FLJ33870,KIAA0439,NEDD4-2,RSP5,hNedd4-2 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4-like
Band: 18q21.31
Quick LinksEntrez ID:23327; OMIM: 606384; Uniprot ID:NED4L_HUMAN; ENSEMBL ID: ENSG00000049759; HGNC ID: 7728
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IC-intracellular11244092
GO:0005654TAS-nucleoplasm-
GO:0005771IEA-multivesicular body-
GO:0005794IEA-Golgi apparatus-
GO:0005829TAS-cytosol-
GO:0005886IDAcolocalizes_withplasma membrane22879586
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity19028597
GO:0004842NAS-ubiquitin-protein transferase activity11244092
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11244092
GO:0015459IDA-potassium channel regulator activity17289006
GO:0017080IDA-sodium channel regulator activity11244092
GO:0019870IDA-potassium channel inhibitor activity21463633
GO:0019871IDA-sodium channel inhibitor activity15217910
GO:0044325IPI-ion channel binding15217910
GO:0061630IEA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter-
GO:0000209TAS-protein polyubiquitination-
GO:0003254IDA-regulation of membrane depolarization15217910
GO:0006513IEA-protein monoubiquitination-
GO:0006814NAS-sodium ion transport11244092
GO:0006883NAS-cellular sodium ion homeostasis11244092
GO:0007588NAS-excretion11244092
GO:0010038IDA-response to metal ion11244092
GO:0016567IDA-protein ubiquitination15217910
GO:0016567NAS-protein ubiquitination11244092
GO:0019058TAS-viral life cycle-
GO:0030104NAS-water homeostasis11244092
GO:0034220TAS-ion transmembrane transport-
GO:0034765IDA-regulation of ion transmembrane transport17289006
GO:0042176NAS-regulation of protein catabolic process11244092
GO:0042391IDA-regulation of membrane potential17289006
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process21463633
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process21463633
GO:0045732IEA-positive regulation of protein catabolic process-
GO:0045807NAS-positive regulation of endocytosis11244092
GO:0060306IDA-regulation of membrane repolarization21463633
GO:0070936IDA-protein K48-linked ubiquitination21463633
GO:0086005ISS-ventricular cardiac muscle cell action potential22879586
GO:1901016IDA-regulation of potassium ion transmembrane transporter activity17289006
GO:1901017IDA-negative regulation of potassium ion transmembrane transporter activity21463633
GO:1901380IDA-negative regulation of potassium ion transmembrane transport21463633
GO:1902306IDA-negative regulation of sodium ion transmembrane transport15217910
GO:1903861IDA-positive regulation of dendrite extension23999003
GO:2000009IDA-negative regulation of protein localization to cell surface21463633
GO:2000650IDA-negative regulation of sodium ion transmembrane transporter activity15217910
GO:2001288ISS-positive regulation of caveolin-mediated endocytosis22879586
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NEDD4LARHGDIA11691516169070 Two-hybrid
NEDD4LARHGDIA10688916169070 Two-hybrid
NEDD4LSFN10907215778465 Affinity Capture-MS
NEDD4LSFN11691515778465 Affinity Capture-MS
NEDD4LNR3C11169159649342 Reconstituted Complex
NEDD4LNR3C11091659649342 Reconstituted Complex
NEDD4LSCNN1A11691511244092 14556380 17502380 Affinity Capture-Western; Far Western; Two-hybrid
NEDD4LSCNN1A11224111244092 14556380 17502380 Affinity Capture-Western; Far Western; Two-hybrid
NEDD4LSCNN1B11691511244092 Far Western
NEDD4LSCNN1B11224211244092 Far Western
NEDD4LSCNN1G11691511244092 Far Western
NEDD4LSCNN1G11224411244092 Far Western
NEDD4LUBC11691518498246 Reconstituted Complex
NEDD4LUBC11316418498246 Reconstituted Complex
NEDD4LUBA111316518498246 Reconstituted Complex
NEDD4LUBA111691518498246 Reconstituted Complex
NEDD4LYWHAG11691520936779 Two-hybrid
NEDD4LYWHAG11336420936779 Two-hybrid
NEDD4LYWHAZ11691520936779 Two-hybrid
NEDD4LYWHAZ11336620936779 Two-hybrid
NEDD4LNEDD4L11691518498246 19153599 Biochemical Activity; Far Western
AMOTNEDD4L11691519615732 Affinity Capture-MS
AMOTNEDD4L12755719615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1933754
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-051118-2'