AutismKB 2.0

Annotation Details for FN1


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Basic Information Top
Gene Symbol:FN1 ( CIG,DKFZp686F10164,DKFZp686H0342,DKFZp686I1370,DKFZp686O13149,ED-B,FINC,FN,FNZ,GFND,GFND2,LETS,MSF )
Gene Full Name: fibronectin 1
Band: 2q35
Quick LinksEntrez ID:2335; OMIM: 135600; Uniprot ID:FINC_HUMAN; ENSEMBL ID: ENSG00000115414; HGNC ID: 3778
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005577IDA-fibrinogen complex3997886
GO:0005578IDA-proteinaceous extracellular matrix26571399
GO:0005605IEA-basal lamina-
GO:0005615IDA-extracellular space15292204
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005793IDA-endoplasmic reticulum-Golgi intermediate compartment15308636
GO:0016324IEA-apical plasma membrane-
GO:0031012IDA-extracellular matrix1632457
GO:0031012IDAcolocalizes_withextracellular matrix20551380
GO:0031012ISScolocalizes_withextracellular matrix22261194
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding22952693
GO:0005102IPI-receptor binding17849409
GO:0005178IDA-integrin binding19738201
GO:0005178IMP-integrin binding24658351
GO:0005178IPI-integrin binding11792823
GO:0005515IPI-protein binding1400330
GO:0005518NAS-collagen binding3024962
GO:0008022IPI-protein C-terminus binding16677310
GO:0008201NAS-heparin binding10075919
GO:0016504IEA-peptidase activator activity-
GO:0019899IPI-enzyme binding12167537
GO:0042802IPI-identical protein binding18042364
GO:0051087IPI-chaperone binding17849409
GO:0097718IPI-disordered domain specific binding15292204
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001932IDA-regulation of protein phosphorylation11792823
GO:0002576TAS-platelet degranulation-
GO:0006953IEA-acute-phase response-
GO:0007044IEA-cell-substrate junction assembly-
GO:0007155NAS-cell adhesion1423622
GO:0007161IEA-calcium-independent cell-matrix adhesion-
GO:0008284IDA-positive regulation of cell proliferation25834989
GO:0008360IEA-regulation of cell shape-
GO:0009611NAS-response to wounding7989369
GO:0010628IDA-positive regulation of gene expression25834989
GO:0010952IEA-positive regulation of peptidase activity-
GO:0018149IDA-peptide cross-linking3997886
GO:0022617TAS-extracellular matrix disassembly-
GO:0030198TAS-extracellular matrix organization-
GO:0033622IMP-integrin activation24658351
GO:0034446IDA-substrate adhesion-dependent cell spreading16236823
GO:0034446IMP-substrate adhesion-dependent cell spreading24658351
GO:0035987IDA-endodermal cell differentiation23154389
GO:0042060IEA-wound healing-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0045773IEA-positive regulation of axon extension-
GO:0048146IDA-positive regulation of fibroblast proliferation25834989
GO:0050900TAS-leukocyte migration-
GO:0051702IDA-interaction with symbiont12167537
GO:0052047IDA-interaction with other organism via secreted substance involved in symbiotic interaction17849409
GO:0070372IDA-regulation of ERK1 and ERK2 cascade11792823
GO:1904237IDA-positive regulation of substrate-dependent cell migration, cell attachment to substrate25834989
GO:2001202IDA-negative regulation of transforming growth factor-beta secretion25834989
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FN1AMBP1086217519849 Affinity Capture-Western
FN1AMBP1067577519849 Affinity Capture-Western
FN1APCS10682212100475 Affinity Capture-Western
FN1APCS10862112100475 Affinity Capture-Western
FN1FASLG10862111276204 Reconstituted Complex
FN1FASLG10685211276204 Reconstituted Complex
FN1C1QA1071736981115 Reconstituted Complex
FN1C1QA1086216981115 Reconstituted Complex
FN1CD441073981730778 Affinity Capture-Western; Reconstituted Complex
FN1CD441086211730778 Affinity Capture-Western; Reconstituted Complex
FN1COL7A11076917963647 9169408 Reconstituted Complex
FN1COL7A11086217963647 9169408 Reconstituted Complex
FN1CRP1077916693419 Reconstituted Complex
FN1CRP1086216693419 Reconstituted Complex
FN1EGFR10862120029029 PCA
FN1EGFR10827620029029 PCA
FN1F13A11086218905624 Reconstituted Complex
FN1F13A11084608905624 Reconstituted Complex
FN1FBLN11086211400330 Reconstituted Complex
FN1FBLN11084861400330 Reconstituted Complex
FN1FBLN21084937500359 Reconstituted Complex
FN1FBLN21086217500359 Reconstituted Complex
ITGB7FN11099011372909 Affinity Capture-Western
ITGB7FN11086211372909 Affinity Capture-Western
ITGA5FN11098841532572 Reconstituted Complex
ITGA5FN11086211532572 Reconstituted Complex
ITGB6FN11086211532572 Reconstituted Complex
ITGB6FN11099001532572 Reconstituted Complex
LPAFN11102022531657 Biochemical Activity; Reconstituted Complex
LPAFN11086212531657 Biochemical Activity; Reconstituted Complex
GSNFN11091896092370 Reconstituted Complex
GSNFN11086216092370 Reconstituted Complex
TNCFN11086217499434 Affinity Capture-Western; Reconstituted Complex
TNCFN11096027499434 Affinity Capture-Western; Reconstituted Complex
MEP1AFN11086218063866 Biochemical Activity
MEP1AFN11103878063866 Biochemical Activity
MEP1BFN11086218063866 Biochemical Activity
MEP1BFN11103888063866 Biochemical Activity
PLATFN11113438360181 Reconstituted Complex
PLATFN11086218360181 Reconstituted Complex
PLGFN11113568360181 Reconstituted Complex
PLGFN11086218360181 Reconstituted Complex
REG3AFN11111038997243 Reconstituted Complex
REG3AFN11086218997243 Reconstituted Complex
VHLFN11086219651579 Affinity Capture-Western
VHLFN11132699651579 Affinity Capture-Western
SDC2FN111228510772816 Reconstituted Complex
SDC2FN110862110772816 Reconstituted Complex
CXCL12FN111228811023498 Reconstituted Complex
CXCL12FN110862111023498 Reconstituted Complex
MIAFN110862111157741 Reconstituted Complex
MIAFN111383411157741 Reconstituted Complex
IGFBP3FN110970711344214 12127836 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IGFBP3FN110862111344214 12127836 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LACRTFN110862111419941 Reconstituted Complex
LACRTFN112465911419941 Reconstituted Complex
HSPG2FN110957111493006 Reconstituted Complex
HSPG2FN110862111493006 Reconstituted Complex
PKD1FN111132711752017 Reconstituted Complex
PKD1FN110862111752017 Reconstituted Complex
MYOCFN111073611773026 Reconstituted Complex
MYOCFN110862111773026 Reconstituted Complex
TGM2FN110862111829448 Reconstituted Complex
TGM2FN111291011829448 Reconstituted Complex
TGFBIFN110862111867580 Reconstituted Complex
TGFBIFN111290311867580 Reconstituted Complex
TSHRFN110862111981027 Reconstituted Complex
TSHRFN111310411981027 Reconstituted Complex
NOVFN111091812902636 Reconstituted Complex
NOVFN110862112902636 Reconstituted Complex
TRIB3FN110862118276110 Affinity Capture-Western; Two-hybrid
TRIB3FN112175618276110 Affinity Capture-Western; Two-hybrid
Gene Symbol Interactant Interaction ID References Description
SFRP2FN121805714709558 SFRP2 interacts with an unspecified isoform of FN1 (FN). This interaction was modeled on a demonstrated interaction between canine SFRP2 and human FN1.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
FN1FN1_A3076C, FN1_HaeIIb, FN1_MspI Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95566
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000426-1'