Annotation Details for ARHGEF12
Basic Information Top
| Gene Symbol: | ARHGEF12 ( DKFZp686O2372,KIAA0382,LARG,PRO2792 ) |
|---|---|
| Gene Full Name: | Rho guanine nucleotide exchange factor (GEF) 12 |
| Band: | 11q23.3 |
| Quick Links | Entrez ID:23365; OMIM: 604763; Uniprot ID:ARHGC_HUMAN; ENSEMBL ID: ENSG00000196914; HGNC ID: 14193 |
| Relate to Another Database: | SFARIGene; denovo-db |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0005737 | IDA | - | cytoplasm | 15755723 |
| GO:0005829 | TAS | - | cytosol | - |
| GO:0016020 | IEA | - | membrane | - |
| GO:0070062 | IDA | - | extracellular exosome | 19056867 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0001664 | IDA | - | G-protein coupled receptor binding | 15755723 |
| GO:0005085 | TAS | - | guanyl-nucleotide exchange factor activity | - |
| GO:0005089 | TAS | - | Rho guanyl-nucleotide exchange factor activity | - |
| GO:0005096 | IEA | - | GTPase activator activity | - |
| GO:0005515 | IPI | - | protein binding | 11724822 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0007186 | IDA | - | G-protein coupled receptor signaling pathway | 15755723 |
| GO:0035023 | IEA | - | regulation of Rho protein signal transduction | - |
| GO:0035556 | IEA | - | intracellular signal transduction | - |
| GO:0043065 | TAS | - | positive regulation of apoptotic process | - |
| GO:0043547 | IEA | - | positive regulation of GTPase activity | - |
| GO:0051056 | TAS | - | regulation of small GTPase mediated signal transduction | - |
| Gene Symbol | Interactant | Interaction ID | References | Description |
|---|---|---|---|---|
| ARHGEF12 | RHOA | 116945 | 11373293 12515866 | Reconstituted Complex |
| ARHGEF12 | RHOA | 106880 | 11373293 12515866 | Reconstituted Complex |
| ARHGEF12 | GNA12 | 116945 | 11094164 12515866 | Affinity Capture-Western; Phenotypic Enhancement |
| ARHGEF12 | GNA12 | 109030 | 11094164 12515866 | Affinity Capture-Western; Phenotypic Enhancement |
| ARHGEF12 | IGF1R | 116945 | 11724822 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
| ARHGEF12 | IGF1R | 109701 | 11724822 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
| ARHGEF12 | PLXNB1 | 116945 | 12220504 | Affinity Capture-Western; Two-hybrid |
| ARHGEF12 | PLXNB1 | 111377 | 12220504 | Affinity Capture-Western; Two-hybrid |
| ARHGEF12 | TEC | 116945 | 12515866 | Biochemical Activity; Phenotypic Enhancement |
| ARHGEF12 | TEC | 112865 | 12515866 | Biochemical Activity; Phenotypic Enhancement |
| ARHGEF12 | GNA13 | 116945 | 11094164 12515866 | Affinity Capture-Western; Phenotypic Enhancement |
| ARHGEF12 | GNA13 | 115914 | 11094164 12515866 | Affinity Capture-Western; Phenotypic Enhancement |
| PLXNB2 | ARHGEF12 | 116945 | 12183458 | Affinity Capture-Western |
| PLXNB2 | ARHGEF12 | 117178 | 12183458 | Affinity Capture-Western |
| ARHGEF12 | ARHGEF12 | 116945 | 14712228 | Affinity Capture-Western |
| No data |
| No data |
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