AutismKB 2.0

Annotation Details for SRGAP2


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Basic Information Top
Gene Symbol:SRGAP2 ( ARHGAP34,FNBP2,KIAA0456,SRGAP3 )
Gene Full Name: SLIT-ROBO Rho GTPase activating protein 2
Band: 1q32.1
Quick LinksEntrez ID:23380; OMIM: 606524; Uniprot ID:FNBP2_HUMAN; ENSEMBL ID: ENSG00000163486; HGNC ID: 19751
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IBA-cytoplasm-
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane21148482
GO:0014069ISS-postsynaptic density-
GO:0030027IDA-lamellipodium20810653
GO:0030054IEA-cell junction-
GO:0044327IDA-dendritic spine head22559944
GO:0045211ISS-postsynaptic membrane-
GO:0045335ISS-phagocytic vesicle-
GO ID Evidence Qualifier GO_term References
GO:0005096IDA-GTPase activator activity21148482
GO:0005096IMP-GTPase activator activity20810653
GO:0005096TAS-GTPase activator activity-
GO:0005515IPI-protein binding16318909
GO:0042803IDA-protein homodimerization activity20810653
GO:0048365IDA-Rac GTPase binding20810653
GO ID Evidence Qualifier GO_term References
GO:0003363IMP-lamellipodium assembly involved in ameboidal cell migration20810653
GO:0007165IEA-signal transduction-
GO:0008283IMPNOTcell proliferation20810653
GO:0021816ISS-extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration-
GO:0034446IMP-substrate adhesion-dependent cell spreading20810653
GO:0043547IDA-positive regulation of GTPase activity21148482
GO:0043547IMP-positive regulation of GTPase activity20810653
GO:0046847IDA-filopodium assembly22559944
GO:0048812ISS-neuron projection morphogenesis-
GO:0051014IDA-actin filament severing21148482
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0060548IMPNOTnegative regulation of cell death20810653
GO:0060996IDA-dendritic spine development22559944
GO:2001223IDA-negative regulation of neuron migration22559944
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SRGAP2DIAPH111695619041431 Affinity Capture-MS
SRGAP2DIAPH110807319041431 Affinity Capture-MS
SRGAP2WAS11695619041431 Affinity Capture-MS
SRGAP2WAS11329319041431 Affinity Capture-MS
SRGAP2WIPF111695619041431 Affinity Capture-MS
SRGAP2WIPF111329519041431 Affinity Capture-MS
SRGAP2SLC25A1211695619041431 Affinity Capture-MS
SRGAP2SLC25A1211416419041431 Affinity Capture-MS
ITSN2SRGAP211909819041431 Affinity Capture-MS
ITSN2SRGAP211695619041431 Affinity Capture-MS
ATAD3ASRGAP211695619041431 Affinity Capture-MS
ATAD3ASRGAP212050619041431 Affinity Capture-MS
YLPM1SRGAP211695619041431 Affinity Capture-MS
YLPM1SRGAP212111719041431 Affinity Capture-MS
MYO1GSRGAP211695619041431 Affinity Capture-MS
MYO1GSRGAP212203119041431 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109605
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041210-103'