AutismKB 2.0

Annotation Details for DICER1


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Basic Information Top
Gene Symbol:DICER1 ( DCR1,Dicer,HERNA,KIAA0928 )
Gene Full Name: dicer 1, ribonuclease type III
Band: 14q32.13
Quick LinksEntrez ID:23405; OMIM: 606241; Uniprot ID:DICER_HUMAN; ENSEMBL ID: ENSG00000100697; HGNC ID: 17098
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005737IBA-cytoplasm-
GO:0005793IEA-endoplasmic reticulum-Golgi intermediate compartment-
GO:0005829TAS-cytosol-
GO:0016442IDANOTRISC complex16357216
GO:0030424IEA-axon-
GO:0030425IEA-dendrite-
GO:0030426IEA-growth cone-
GO:0033167IC-ARC complex19701182
GO:0070062IDA-extracellular exosome28159509
GO:0070578IDA-RISC-loading complex15973356
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003725IDA-double-stranded RNA binding12411504
GO:0003725IMP-double-stranded RNA binding19701182
GO:0004386IEA-helicase activity-
GO:0004521IDA-endoribonuclease activity25549615
GO:0004521IMP-endoribonuclease activity18325616
GO:0004521TAS-endoribonuclease activity19820710
GO:0004525EXP-ribonuclease III activity11201747
GO:0004525IDA-ribonuclease III activity21753850
GO:0005515IPI-protein binding12526743
GO:0005524IEA-ATP binding-
GO:0019904IPI-protein domain specific binding12526743
GO:0035197IDA-siRNA binding15973356
GO:0046872IEA-metal ion binding-
GO:0070883IDA-pre-miRNA binding18508075
GO:0070883IDAcontributes_topre-miRNA binding18178619
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0010586TAS-miRNA metabolic process-
GO:0010626ISS-negative regulation of Schwann cell proliferation-
GO:0014040ISS-positive regulation of Schwann cell differentiation-
GO:0021675ISS-nerve development-
GO:0030422IDA-production of siRNA involved in RNA interference15973356
GO:0030422TAS-production of siRNA involved in RNA interference-
GO:0030423IMP-targeting of mRNA for destruction involved in RNA interference15973356
GO:0031054IDA-pre-miRNA processing15973356
GO:0031643ISS-positive regulation of myelination-
GO:0032290ISS-peripheral nervous system myelin formation-
GO:0033168IMP-conversion of ds siRNA to ss siRNA involved in RNA interference19701182
GO:0035087IDA-siRNA loading onto RISC involved in RNA interference15973356
GO:0035196IDA-production of miRNAs involved in gene silencing by miRNA15973356
GO:0035196ISS-production of miRNAs involved in gene silencing by miRNA-
GO:0035280IDA-miRNA loading onto RISC involved in gene silencing by miRNA18178619
GO:0036404IMP-conversion of ds siRNA to ss siRNA18325616
GO:0048812ISS-neuron projection morphogenesis-
GO:0090502IDA-RNA phosphodiester bond hydrolysis, endonucleolytic21753850
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2C2DICER111697812526743 Affinity Capture-Western
EIF2C2DICER111804112526743 Affinity Capture-Western
PIWIL4DICER112681812906857 Affinity Capture-Western
PIWIL4DICER111697812906857 Affinity Capture-Western
EIF2C3DICER112817712906857 Affinity Capture-Western
EIF2C3DICER111697812906857 Affinity Capture-Western
EIF2C4DICER112817812906857 Affinity Capture-Western
EIF2C4DICER111697812906857 Affinity Capture-Western
EIF2C1DICER111697812906857 Affinity Capture-Western
EIF2C1DICER111772612906857 Affinity Capture-Western
PIWIL3DICER113692112906857 Affinity Capture-Western
PIWIL3DICER111697812906857 Affinity Capture-Western
PIWIL2DICER111697812906857 Affinity Capture-Western
PIWIL2DICER112043112906857 Affinity Capture-Western
USP49DICER111697819615732 Affinity Capture-MS
USP49DICER111738219615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2177178
  • Data Attributes: MGI curated and HomoloGene calculated
No data