AutismKB 2.0

Annotation Details for HEY1


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Basic Information Top
Gene Symbol:HEY1 ( BHLHb31,CHF2,HERP2,HESR1,HRT-1,MGC1274,OAF1 )
Gene Full Name: hairy/enhancer-of-split related with YRPW motif 1
Band: 8q21.13
Quick LinksEntrez ID:23462; OMIM: 602953; Uniprot ID:HEY1_HUMAN; ENSEMBL ID: ENSG00000164683; HGNC ID: 4880
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737ISS-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000983ISS-transcription factor activity, RNA polymerase II core promoter sequence-specific-
GO:0000988IDA-transcription factor activity, protein binding21290414
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding15485867
GO:0005515IPI-protein binding10692439
GO:0008134NAS-transcription factor binding17611704
GO:0035939IDA-microsatellite binding21290414
GO:0046983IEA-protein dimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter16043483
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter11486045
GO:0001525IEP-angiogenesis11866539
GO:0003184ISS-pulmonary valve morphogenesis-
GO:0003190ISS-atrioventricular valve formation-
GO:0003198ISS-epithelial to mesenchymal transition involved in endocardial cushion formation-
GO:0003203ISS-endocardial cushion morphogenesis-
GO:0003208ISS-cardiac ventricle morphogenesis-
GO:0006351IEA-transcription, DNA-templated-
GO:0007219IDA-Notch signaling pathway10964718
GO:0035912ISS-dorsal aorta morphogenesis-
GO:0036304ISS-umbilical cord morphogenesis-
GO:0045746IDA-negative regulation of Notch signaling pathway18239137
GO:0045892IDA-negative regulation of transcription, DNA-templated15485867
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0060317ISS-cardiac epithelial to mesenchymal transition-
GO:0060347ISS-heart trabecula formation-
GO:0060411ISS-cardiac septum morphogenesis-
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060716ISS-labyrinthine layer blood vessel development-
GO:0060842ISS-arterial endothelial cell differentiation-
GO:0061314IC-Notch signaling involved in heart development17259303
GO:0071385IEA-cellular response to glucocorticoid stimulus-
GO:2000678IDA-negative regulation of transcription regulatory region DNA binding18239137
GO:2000820IDA-negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation18239137
GO:2001212ISS-regulation of vasculogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HEY1MYOD111073711279181 Affinity Capture-Western
HEY1MYOD111702511279181 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1341800
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000607-70'