AutismKB 2.0

Annotation Details for HEY2


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Basic Information Top
Gene Symbol:HEY2 ( CHF1,GRIDLOCK,GRL,HERP1,HESR2,HRT2,MGC10720,bHLHb32 )
Gene Full Name: hairy/enhancer-of-split related with YRPW motif 2
Band: 6q22.31
Quick LinksEntrez ID:23493; OMIM: 604674; Uniprot ID:HEY2_HUMAN; ENSEMBL ID: ENSG00000135547; HGNC ID: 4881
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737ISS-cytoplasm-
GO:0016580IDAcolocalizes_withSin3 complex11486045
GO:0017053IDA-transcriptional repressor complex11486045
GO ID Evidence Qualifier GO_term References
GO:0000983ISS-transcription factor activity, RNA polymerase II core promoter sequence-specific-
GO:0000988IDA-transcription factor activity, protein binding21290414
GO:0001102IPI-RNA polymerase II activating transcription factor binding16293227
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding15485867
GO:0005515IPI-protein binding10692439
GO:0008134NAS-transcription factor binding17611704
GO:0035939IDA-microsatellite binding21290414
GO:0042803IEA-protein homodimerization activity-
GO:0042826IPI-histone deacetylase binding12535671
GO:0043565IDA-sequence-specific DNA binding11486045
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter10692439
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter11486045
GO:0001570ISS-vasculogenesis-
GO:0003150ISS-muscular septum morphogenesis-
GO:0003151ISS-outflow tract morphogenesis-
GO:0003184ISS-pulmonary valve morphogenesis-
GO:0003186ISS-tricuspid valve morphogenesis-
GO:0003195IEA-tricuspid valve formation-
GO:0003199IEA-endocardial cushion to mesenchymal transition involved in heart valve formation-
GO:0003208ISS-cardiac ventricle morphogenesis-
GO:0003214ISS-cardiac left ventricle morphogenesis-
GO:0003215ISS-cardiac right ventricle morphogenesis-
GO:0003222IEA-ventricular trabecula myocardium morphogenesis-
GO:0006351IEA-transcription, DNA-templated-
GO:0007219ISS-Notch signaling pathway-
GO:0009948IEA-anterior/posterior axis specification-
GO:0010460IEA-positive regulation of heart rate-
GO:0010621ISS-negative regulation of transcription by transcription factor localization-
GO:0010629ISS-negative regulation of gene expression-
GO:0010667IEA-negative regulation of cardiac muscle cell apoptotic process-
GO:0014031ISS-mesenchymal cell development-
GO:0014898IEA-cardiac muscle hypertrophy in response to stress-
GO:0035910ISS-ascending aorta morphogenesis-
GO:0035912ISS-dorsal aorta morphogenesis-
GO:0036304ISS-umbilical cord morphogenesis-
GO:0045165IEA-cell fate commitment-
GO:0045607IEA-regulation of auditory receptor cell differentiation-
GO:0045746IEA-negative regulation of Notch signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated12535671
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0051145NAS-smooth muscle cell differentiation10692439
GO:0055015ISS-ventricular cardiac muscle cell development-
GO:0060045IEA-positive regulation of cardiac muscle cell proliferation-
GO:0060317ISS-cardiac epithelial to mesenchymal transition-
GO:0060347IEA-heart trabecula formation-
GO:0060411ISS-cardiac septum morphogenesis-
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060413ISS-atrial septum morphogenesis-
GO:0060633IDA-negative regulation of transcription initiation from RNA polymerase II promoter10692439
GO:0060716ISS-labyrinthine layer blood vessel development-
GO:0060842ISS-arterial endothelial cell differentiation-
GO:0060948IEA-cardiac vascular smooth muscle cell development-
GO:0060977IEA-coronary vasculature morphogenesis-
GO:0061156ISS-pulmonary artery morphogenesis-
GO:0061314IC-Notch signaling involved in heart development12372254
GO:0065004IEA-protein-DNA complex assembly-
GO:0090102IEA-cochlea development-
GO:0097084IEP-vascular smooth muscle cell development15821257
GO:2000678IDA-negative regulation of transcription regulatory region DNA binding10692439
GO:2000723ISS-negative regulation of cardiac vascular smooth muscle cell differentiation-
GO:2000820ISS-negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-
GO:2001212ISS-regulation of vasculogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HEY2HDAC111704511486045 Reconstituted Complex
HEY2HDAC110931511486045 Reconstituted Complex
HEY2HES111704511486045 Reconstituted Complex
HEY2HES110951411486045 Reconstituted Complex
HEY2PLSCR111137316189514 Two-hybrid
HEY2PLSCR111704516189514 Two-hybrid
HEY2HAND111704510924525 Reconstituted Complex
HEY2HAND111481410924525 Reconstituted Complex
HEY2NCOR111704511486045 Affinity Capture-Western; Reconstituted Complex
HEY2NCOR111497311486045 Affinity Capture-Western; Reconstituted Complex
HEY2HDAC911704511486045 Affinity Capture-Western
HEY2HDAC911508311486045 Affinity Capture-Western
HEY2SIRT111704512535671 Affinity Capture-Western; Reconstituted Complex
HEY2SIRT111698312535671 Affinity Capture-Western; Reconstituted Complex
SIN3AHEY211704511486045 Affinity Capture-Western
SIN3AHEY211743911486045 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1341884
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000526-1'