AutismKB 2.0

Annotation Details for SUZ12


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SUZ12 ( CHET9,JJAZ1,KIAA0160 )
Gene Full Name: suppressor of zeste 12 homolog (Drosophila)
Band: 17q11.2
Quick LinksEntrez ID:23512; OMIM: 606245; Uniprot ID:SUZ12_HUMAN; ENSEMBL ID: ENSG00000178691; HGNC ID: 17101
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001739IEA-sex chromatin-
GO:0005634IDA-nucleus21630459
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus-
GO:0016586IBA-RSC complex-
GO:0016604IDA-nuclear body-
GO:0032993IEA-protein-DNA complex-
GO:0035098IDA-ESC/E(Z) complex20075857
GO:0035098IMP-ESC/E(Z) complex15385962
GO ID Evidence Qualifier GO_term References
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0003723IEA-RNA binding-
GO:0005515IPI-protein binding17560333
GO:0031490IBA-chromatin DNA binding-
GO:0035064IDA-methylated histone binding21029866
GO:0042054IMP-histone methyltransferase activity15385962
GO:0042054IMPcontributes_tohistone methyltransferase activity28229514
GO:0046872IEA-metal ion binding-
GO:0046976IMPcontributes_tohistone methyltransferase activity (H3-K27 specific)28229514
GO:1990841IEA-promoter-specific chromatin binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IBA-regulation of transcription, DNA-templated-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0016574IEA-histone ubiquitination-
GO:0045596IMP-negative regulation of cell differentiation19847889
GO:0045814TAS-negative regulation of gene expression, epigenetic-
GO:0070734IEA-histone H3-K27 methylation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SUZ12CREB111705920211142 Two-hybrid
SUZ12CREB110777520211142 Two-hybrid
SUZ12EWSR110843120211142 Two-hybrid
SUZ12EWSR111705920211142 Two-hybrid
SUZ12EZH111705919026780 19026781 Affinity Capture-Western
SUZ12EZH110844519026780 19026781 Affinity Capture-Western
SUZ12EZH211705915882624 18285464 18453536 18483221 18931660 19026780 19026781 20123894 Affinity Capture-MS; Affinity Capture-Western
SUZ12EZH210844615882624 18285464 18453536 18483221 18931660 19026780 19026781 20123894 Affinity Capture-MS; Affinity Capture-Western
SUZ12GTF2I11705917970752 Affinity Capture-Western
SUZ12GTF2I10922417970752 Affinity Capture-Western
SUZ12HIST1H1C10926116431907 Reconstituted Complex
SUZ12HIST1H1C11705916431907 Reconstituted Complex
SUZ12HIST1H1A10927516431907 Reconstituted Complex
SUZ12HIST1H1A11705916431907 Reconstituted Complex
SUZ12JARID210992320123894 Affinity Capture-Western
SUZ12JARID211705920123894 Affinity Capture-Western
SUZ12PHF111127118285464 18385154 Affinity Capture-MS; Affinity Capture-Western
SUZ12PHF111705918285464 18385154 Affinity Capture-MS; Affinity Capture-Western
SUZ12KDM5A11705918483221 Affinity Capture-Western
SUZ12KDM5A11186218483221 Affinity Capture-Western
SUZ12RBBP411705915225548 Reconstituted Complex
SUZ12RBBP411186315225548 Reconstituted Complex
SUZ12SNAI111249918519590 Affinity Capture-Western
SUZ12SNAI111705918519590 Affinity Capture-Western
SUZ12UBE2I11317718628979 Affinity Capture-Western; Reconstituted Complex
SUZ12UBE2I11705918628979 Affinity Capture-Western; Reconstituted Complex
SUZ12VAV111705915882624 Affinity Capture-Western
SUZ12VAV111325215882624 Affinity Capture-Western
SUZ12EED11705915225548 15385962 18285464 18483221 19026780 19026781 Affinity Capture-Western; Co-purification; Reconstituted Complex
SUZ12EED11426515225548 15385962 18285464 18483221 19026780 19026781 Affinity Capture-Western; Co-purification; Reconstituted Complex
SUZ12SETDB111520214536086 Co-purification
SUZ12SETDB111705914536086 Co-purification
SUZ12CTCF11705918662993 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SUZ12CTCF11590618662993 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SUZ12MTF211705920123894 Affinity Capture-Western
SUZ12MTF211649920123894 Affinity Capture-Western
SUZ12SIRT111705915684044 Affinity Capture-Western
SUZ12SIRT111698315684044 Affinity Capture-Western
SETD8SUZ1213249012351676 Co-purification
SETD8SUZ1211705912351676 Co-purification
AEBP2SUZ1212573615225548 Reconstituted Complex
AEBP2SUZ1211705915225548 Reconstituted Complex
WDR77SUZ1211705916712789 Affinity Capture-Western; Reconstituted Complex
WDR77SUZ1212253216712789 Affinity Capture-Western; Reconstituted Complex
SUZ12SUZ1211705919026781 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1261758
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3255'