AutismKB 2.0

Annotation Details for SCRIB


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Basic Information Top
Gene Symbol:SCRIB ( CRIB1,SCRB1,SCRIB1,Vartul )
Gene Full Name: scribbled homolog (Drosophila)
Band: 8q24.3
Quick LinksEntrez ID:23513; OMIM: 607733; Uniprot ID:SCRIB_HUMAN; ENSEMBL ID: ENSG00000180900; HGNC ID: 30377
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005886IDA-plasma membrane15182672
GO:0005886IDAcolocalizes_withplasma membrane16611247
GO:0005911IDA-cell-cell junction15649318
GO:0005913IDA-cell-cell adherens junction16965391
GO:0008328IBAcolocalizes_withionotropic glutamate receptor complex-
GO:0014069IBA-postsynaptic density-
GO:0016323IBA-basolateral plasma membrane-
GO:0030027IEA-lamellipodium-
GO:0030054IDA-cell junction-
GO:0031252IDAcolocalizes_withcell leading edge18716323
GO:0034750IDA-Scrib-APC-beta-catenin complex16611247
GO:0035748IEA-myelin sheath abaxonal region-
GO:0042734IDAcolocalizes_withpresynaptic membrane15182672
GO:0044291IEA-cell-cell contact zone-
GO:0045211IDAcolocalizes_withpostsynaptic membrane15182672
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0004385IBA-guanylate kinase activity-
GO:0005515IPI-protein binding15182672
GO:0035255IBA-ionotropic glutamate receptor binding-
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0001843IMP-neural tube closure22095531
GO:0001921IMP-positive regulation of receptor recycling15775968
GO:0007268IBA-chemical synaptic transmission-
GO:0008105IEA-asymmetric protein localization-
GO:0008283IDA-cell proliferation16965391
GO:0016032IEA-viral process-
GO:0016080IEA-synaptic vesicle targeting-
GO:0016337IGI-single organismal cell-cell adhesion16344308
GO:0016477IMP-cell migration18716323
GO:0021747IEA-cochlear nucleus development-
GO:0035089IMP-establishment of apical/basal cell polarity19041750
GO:0042060IEA-wound healing-
GO:0043065IMP-positive regulation of apoptotic process19041750
GO:0043113IBA-receptor clustering-
GO:0043615IEA-astrocyte cell migration-
GO:0045197IBA-establishment or maintenance of epithelial cell apical/basal polarity-
GO:0045930IDA-negative regulation of mitotic cell cycle16965391
GO:0046037IEA-GMP metabolic process-
GO:0046710IEA-GDP metabolic process-
GO:0048488IEA-synaptic vesicle endocytosis-
GO:0050918IMP-positive chemotaxis18716323
GO:0060088IEA-auditory receptor cell stereocilium organization-
GO:0060561IMP-apoptotic process involved in morphogenesis19041750
GO:0060603ISS-mammary gland duct morphogenesis-
GO:0071896IMP-protein localization to adherens junction16611247
GO:0090630IMP-activation of GTPase activity19041750
GO:0097120IBA-receptor localization to synapse-
GO:0098887IEA-neurotransmitter receptor transport, endosome to postsynaptic membrane-
GO:0098968IEA-neurotransmitter receptor transport postsynaptic membrane to endosome-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SCRIBDMWD11706019615732 Affinity Capture-MS
SCRIBDMWD10810219615732 Affinity Capture-MS
SCRIBEXOSC1011706015231747 Two-hybrid
SCRIBEXOSC1011140315231747 Two-hybrid
SCRIBPHLPP111684319615732 Affinity Capture-MS
SCRIBPHLPP111706019615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2145950
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030616-572'