AutismKB 2.0

Annotation Details for CLCF1


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Basic Information Top
Gene Symbol:CLCF1 ( BSF-3,BSF3,CISS2,CLC,NNT-1,NNT1,NR6 )
Gene Full Name: cardiotrophin-like cytokine factor 1
Band: 11q13.2
Quick LinksEntrez ID:23529; OMIM: 607672; Uniprot ID:CLCF1_HUMAN; ENSEMBL ID: ENSG00000175505; HGNC ID: 17412
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region10966616
GO:0005576NAS-extracellular region10448081
GO:0005576TAS-extracellular region-
GO:0005622IEA-intracellular-
GO:0070062IDA-extracellular exosome23376485
GO:0097058IDA-CRLF-CLCF1 complex10966616
GO:0097059IDA-CNTFR-CLCF1 complex11285233
GO ID Evidence Qualifier GO_term References
GO:0005102IPI-receptor binding15272019
GO:0005125IDAcontributes_tocytokine activity10966616
GO:0005125NAS-cytokine activity10500198
GO:0005127IDA-ciliary neurotrophic factor receptor binding11285233
GO:0005127IDAcontributes_tociliary neurotrophic factor receptor binding10966616
GO:0005515IPI-protein binding10966616
GO:0008083TAS-growth factor activity14632778
GO:0046982IDA-protein heterodimerization activity10966616
GO ID Evidence Qualifier GO_term References
GO:0002639ISS-positive regulation of immunoglobulin production-
GO:0007166IBA-cell surface receptor signaling pathway-
GO:0007166ISS-cell surface receptor signaling pathway-
GO:0007259ISS-JAK-STAT cascade-
GO:0008284IDA-positive regulation of cell proliferation10966616
GO:0019221NAS-cytokine-mediated signaling pathway10500198
GO:0030183ISS-B cell differentiation-
GO:0030890IBA-positive regulation of B cell proliferation-
GO:0030890ISS-positive regulation of B cell proliferation-
GO:0042531IDA-positive regulation of tyrosine phosphorylation of STAT protein10966616
GO:0042531TAS-positive regulation of tyrosine phosphorylation of STAT protein14632778
GO:0043524IDA-negative regulation of neuron apoptotic process10966616
GO:0048295ISS-positive regulation of isotype switching to IgE isotypes-
GO:0048711ISS-positive regulation of astrocyte differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CLCF1CNTFR10767111285233 Affinity Capture-Western; Co-purification
CLCF1CNTFR11707511285233 Affinity Capture-Western; Co-purification
CLCF1CRLF111467010966616 Affinity Capture-Western
CLCF1CRLF111707510966616 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1930088
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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