AutismKB 2.0

Annotation Details for DDX58


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Basic Information Top
Gene Symbol:DDX58 ( DKFZp434J1111,DKFZp686N19181,FLJ13599,RIG-I )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Band: 9p21.1
Quick LinksEntrez ID:23586; OMIM: 609631; Uniprot ID:DDX58_HUMAN; ENSEMBL ID: ENSG00000107201; HGNC ID: 19102
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm21102435
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005923IDA-bicellular tight junction19122199
GO:0015629IDA-actin cytoskeleton19122199
GO:0032587IDA-ruffle membrane19122199
GO ID Evidence Qualifier GO_term References
GO:0003690IEA-double-stranded DNA binding-
GO:0003725IDA-double-stranded RNA binding19576794
GO:0003725IMP-double-stranded RNA binding19211564
GO:0003725TAS-double-stranded RNA binding17079289
GO:0003727IMP-single-stranded RNA binding19211564
GO:0004386IEA-helicase activity-
GO:0005515IPI-protein binding16127453
GO:0005524IEA-ATP binding-
GO:0008270IDA-zinc ion binding18243112
GO:0031625IPI-ubiquitin protein ligase binding26471729
GO:0042802IPI-identical protein binding21102435
GO ID Evidence Qualifier GO_term References
GO:0002230IMP-positive regulation of defense response to virus by host19609254
GO:0009597IDA-detection of virus17079289
GO:0009615TAS-response to virus21616437
GO:0010628IDA-positive regulation of gene expression24409285
GO:0016579TAS-protein deubiquitination-
GO:0030334IDA-regulation of cell migration19122199
GO:0032480TAS-negative regulation of type I interferon production-
GO:0032725IDA-positive regulation of granulocyte macrophage colony-stimulating factor production24409285
GO:0032727IDA-positive regulation of interferon-alpha production19576794
GO:0032727IMP-positive regulation of interferon-alpha production19609254
GO:0032728IDA-positive regulation of interferon-beta production17079289
GO:0032728IMP-positive regulation of interferon-beta production19211564
GO:0032755IDA-positive regulation of interleukin-6 production24409285
GO:0032757IDA-positive regulation of interleukin-8 production24409285
GO:0034344TAS-regulation of type III interferon production21616437
GO:0039528TAS-cytoplasmic pattern recognition receptor signaling pathway in response to virus21616437
GO:0039529IMP-RIG-I signaling pathway19211564
GO:0042993IDA-positive regulation of transcription factor import into nucleus17079289
GO:0043330IEA-response to exogenous dsRNA-
GO:0045087IMP-innate immune response19609254
GO:0045087TAS-innate immune response-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter17079289
GO:0051091IC-positive regulation of sequence-specific DNA binding transcription factor activity17079289
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DDX58CYLD10792018636086 Affinity Capture-Western
DDX58CYLD11712118636086 Affinity Capture-Western
DDX58UBE2K10934017719635 Biochemical Activity
DDX58UBE2K11712117719635 Biochemical Activity
DDX58IRF310986918636086 Affinity Capture-Western
DDX58IRF311712118636086 Affinity Capture-Western
DDX58UBC11316417392790 17719635 18636086 Affinity Capture-Western
DDX58UBC11712117392790 17719635 18636086 Affinity Capture-Western
DDX58UBE2D111316917719635 Biochemical Activity
DDX58UBE2D111712117719635 Biochemical Activity
DDX58UBE2D211317017719635 Biochemical Activity
DDX58UBE2D211712117719635 Biochemical Activity
DDX58UBE2D311317117719635 Biochemical Activity
DDX58UBE2D311712117719635 Biochemical Activity
DDX58TRIM2511350017392790 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DDX58TRIM2511712117392790 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DDX58ISG1511499517719635 Affinity Capture-Western
DDX58ISG1511712117719635 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2442858
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090821-7'