AutismKB 2.0

Annotation Details for LY96


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Basic Information Top
Gene Symbol:LY96 ( ESOP-1,MD-2,MD2,ly-96 )
Gene Full Name: lymphocyte antigen 96
Band: 8q21.11
Quick LinksEntrez ID:23643; OMIM: 605243; Uniprot ID:LY96_HUMAN; ENSEMBL ID: ENSG00000154589; HGNC ID: 17156
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IEA-extracellular space-
GO:0005886TAS-plasma membrane-
GO:0010008TAS-endosome membrane-
GO:0031226IDA-intrinsic component of plasma membrane11274165
GO:0046696IDA-lipopolysaccharide receptor complex11274165
GO ID Evidence Qualifier GO_term References
GO:0001875IDA-lipopolysaccharide receptor activity19252480
GO:0005515IPI-protein binding17803912
GO:0015026TAS-coreceptor activity10359581
GO ID Evidence Qualifier GO_term References
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0002756TAS-MyD88-independent toll-like receptor signaling pathway-
GO:0006954IEA-inflammatory response-
GO:0006968TAS-cellular defense response10359581
GO:0007166TAS-cell surface receptor signaling pathway10359581
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0031663IEA-lipopolysaccharide-mediated signaling pathway-
GO:0031666IEA-positive regulation of lipopolysaccharide-mediated signaling pathway-
GO:0032496IDA-response to lipopolysaccharide12594207
GO:0032497IDA-detection of lipopolysaccharide19252480
GO:0032760ISS-positive regulation of tumor necrosis factor production-
GO:0034128TAS-negative regulation of MyD88-independent toll-like receptor signaling pathway-
GO:0034142ISS-toll-like receptor 4 signaling pathway-
GO:0034142TAS-toll-like receptor 4 signaling pathway-
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0045087IEA-innate immune response-
GO:0070266TAS-necroptotic process-
GO:0097190TAS-apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LY96TLR211717011160242 Affinity Capture-Western
LY96TLR211295211160242 Affinity Capture-Western
LY96TLR411717010359581 11976338 Affinity Capture-Western
LY96TLR411295410359581 11976338 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
LY96TLR419665510359581 MD-2 interacts with TLR4
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1341909
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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