AutismKB 2.0

Annotation Details for PPP1R15A


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Basic Information Top
Gene Symbol:PPP1R15A ( GADD34 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 15A
Band: 19q13.2
Quick LinksEntrez ID:23645; OMIM: 611048; Uniprot ID:PR15A_HUMAN; ENSEMBL ID: ENSG00000087074; HGNC ID: 14375
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000164IDA-protein phosphatase type 1 complex11564868
GO:0005737IDA-cytoplasm21518769
GO:0005739IDA-mitochondrion21518769
GO:0005741IEA-mitochondrial outer membrane-
GO:0005783IDA-endoplasmic reticulum12556489
GO:0005789NAS-endoplasmic reticulum membrane21518769
GO:0005794IDA-Golgi apparatus21518769
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane21518769
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11564868
GO:0008157IDA-protein phosphatase 1 binding11564868
GO:0008157IPI-protein phosphatase 1 binding12556489
GO:0019888IC-protein phosphatase regulator activity11564868
GO:0019901IPI-protein kinase binding11517336
GO:0072542IC-protein phosphatase activator activity21518769
GO ID Evidence Qualifier GO_term References
GO:0006915TAS-apoptotic process9153226
GO:0006974TAS-cellular response to DNA damage stimulus9153226
GO:0007050TAS-cell cycle arrest9153226
GO:0030968IEA-endoplasmic reticulum unfolded protein response-
GO:0032058IC-positive regulation of translational initiation in response to stress12556489
GO:0032515IDA-negative regulation of phosphoprotein phosphatase activity11564868
GO:0032516IDA-positive regulation of phosphoprotein phosphatase activity11564868
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0034976IDA-response to endoplasmic reticulum stress12556489
GO:0035308IDA-negative regulation of protein dephosphorylation11564868
GO:0036496IDA-regulation of translational initiation by eIF2 alpha dephosphorylation12556489
GO:0045943IEA-positive regulation of transcription from RNA polymerase I promoter-
GO:0060734IEA-regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation-
GO:0070059TAS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress22934019
GO:0070262IEA-peptidyl-serine dephosphorylation-
GO:0070972IMP-protein localization to endoplasmic reticulum12556489
GO:1902310IDA-positive regulation of peptidyl-serine dephosphorylation11564868
GO:1903898TAS-negative regulation of PERK-mediated unfolded protein response22013210
GO:1903912IEA-negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation-
GO:1903917IDA-positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation21518769
GO:1903917TAS-positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation22013210
GO:1990441IEA-negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PPP1R15ABAG111717212724406 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP1R15ABAG110704912724406 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP1R15AEIF2S111717212556489 Affinity Capture-Western
PPP1R15AEIF2S110828512556489 Affinity Capture-Western
PPP1R15AHSPA810954412724406 Affinity Capture-Western
PPP1R15AHSPA811717212724406 Affinity Capture-Western
PPP1R15AIKBKB10976718362886 Affinity Capture-Western
PPP1R15AIKBKB11717218362886 Affinity Capture-Western
PPP1R15ALYN11024511517336 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP1R15ALYN11717211517336 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP1R15AMLL11717210490642 Affinity Capture-Western; Two-hybrid
PPP1R15AMLL11044310490642 Affinity Capture-Western; Two-hybrid
PPP1R15APPP1CA11149311564868 12016208 12724406 Affinity Capture-Western; Phenotypic Suppression
PPP1R15APPP1CA11717211564868 12016208 12724406 Affinity Capture-Western; Phenotypic Suppression
PPP1R15APPP1CB11149411564868 12016208 Affinity Capture-Western; Phenotypic Suppression
PPP1R15APPP1CB11717211564868 12016208 Affinity Capture-Western; Phenotypic Suppression
PPP1R15APPP1CC11149511564868 12016208 14670976 Affinity Capture-Western; Co-purification; Phenotypic Suppression
PPP1R15APPP1CC11717211564868 12016208 14670976 Affinity Capture-Western; Co-purification; Phenotypic Suppression
PPP1R15ASMARCB111717210490642 12016208 Affinity Capture-Western; Reconstituted Complex
PPP1R15ASMARCB111248210490642 12016208 Affinity Capture-Western; Reconstituted Complex
PPP1R15ATSN11309810434033 Reconstituted Complex; Two-hybrid
PPP1R15ATSN11717210434033 Reconstituted Complex; Two-hybrid
PPP1R15ABCAR111493416169070 Two-hybrid
PPP1R15ABCAR111717216169070 Two-hybrid
PPP1R15AHABP411717216455055 Two-hybrid
PPP1R15AHABP411658716455055 Two-hybrid
CUEDC2PPP1R15A11717218362886 Affinity Capture-Western; Two-hybrid
CUEDC2PPP1R15A12247518362886 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1927072
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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